Treatment of NAFLD with diet, physical activity and exercise
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TLDR
Clinical evidence strongly supports the role of lifestyle modification as a primary therapy for the management of NAFLD and NASH and should be accompanied by the implementation of strategies to avoid relapse and weight regain.About:
This article is published in Journal of Hepatology.The article was published on 2017-10-01 and is currently open access. It has received 740 citations till now. The article focuses on the topics: Weight loss & Steatohepatitis.read more
Citations
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MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease.
TL;DR: Experts reached consensus that NAFLD does not reflect current knowledge and metabolic (dysfunction) associated fatty liver disease "MAFLD" was suggested as a more appropriate overarching term and opens the door for efforts from the research community to update the nomenclature and sub-phenotype the disease in order to accelerate the translational path to new treatments.
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Non-alcoholic fatty liver disease - A global public health perspective.
TL;DR: Given the rapidly growing global burden of NAFLD and NASH, efforts must continue to find accurate non-invasive diagnostic and prognostic biomarkers, to develop effective treatments for individuals with advanced NASH and prevention methods for individuals at high risk of NA FLD and progressive liver disease.
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Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease.
TL;DR: This review summarizes the mechanisms that may account for the excessive production of ROS, the potential mechanistic roles of ROS that drive NAFLD progression, and therapeutic interventions that are related to oxidative stress.
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Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis.
Xuelian Xiong,Xuelian Xiong,Henry Kuang,Sahar Ansari,Tongyu Liu,Jianke Gong,Jianke Gong,Shuai Wang,Xu-Yun Zhao,Yewei Ji,Chuan Li,Liang Guo,Linkang Zhou,Zhimin Chen,Paola León-Mimila,Meng Ting Chung,Katsuo Kurabayashi,Judy S. Opp,Francisco Campos-Pérez,Hugo Villamil-Ramírez,Samuel Canizales-Quinteros,Robert H. Lyons,Carey N. Lumeng,Beiyan Zhou,Ling Qi,Adriana Huertas-Vazquez,Aldons J. Lusis,X.Z. Shawn Xu,Siming Li,Yonghao Yu,Jun Z. Li,Jiandie D. Lin +31 more
TL;DR: The emergence of NASH-associated macrophages (NAMs) is uncovered, which is marked by high expression of triggering receptors expressed on myeloid cells 2 (Trem2), as a feature of mouse and human NASH that is linked to disease severity and highly responsive to pharmacological and dietary interventions.
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Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver.
Paola Dongiovanni,Stefan Stender,Alessandro Pietrelli,Rosellina Margherita Mancina,A. Cespiati,Salvatore Petta,Serena Pelusi,Piero Pingitore,Sara Badiali,Marco Maggioni,Ville Männistö,Stefania Grimaudo,Rosaria Maria Pipitone,Jussi Pihlajamäki,Antonio Craxì,Magdalena Taube,Lena M. S. Carlsson,Silvia Fargion,Stefano Romeo,Stefano Romeo,Stefano Romeo,Julia Kozlitina,Luca Valenti +22 more
TL;DR: The aim of this study was to examine whether hepatic fat accumulation has a causal role in determining liver damage and insulin resistance.
References
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Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomes
Zobair M. Younossi,Zobair M. Younossi,Aaron B. Koenig,Dinan Abdelatif,Yousef Fazel,Linda Henry,Mark Wymer,Mark Wymer +7 more
TL;DR: As the global epidemic of obesity fuels metabolic conditions, the clinical and economic burden of NAFLD will become enormous, and random‐effects models were used to provide point estimates of prevalence, incidence, mortality and incidence rate ratios.
Journal ArticleDOI
Primary Prevention of Cardiovascular Disease with a Mediterranean Diet
Ramon Estruch,Emilio Ros,Jordi Salas-Salvadó,María-Isabel Covas,Dolores Corella,Fernando Arós,Enrique Gómez-Gracia,Valentina Ruiz-Gutiérrez,Miquel Fiol,José Lapetra,Rosa M. Lamuela-Raventós,Lluis Serra-Majem,Xavier Pintó,Josep Basora,Miguel A. Muñoz,José V. Sorlí,José Alfredo Martínez,Miguel Ángel Martínez-González +17 more
TL;DR: Among persons at high cardiovascular risk, a Mediterranean diet supplemented with extra-virgin olive oil or nuts reduced the incidence of major cardiovascular events.
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2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society
Michael D. Jensen,Donna H. Ryan,Caroline M. Apovian,Jamy D. Ard,Anthony G. Comuzzie,Karen A. Donato,Frank B. Hu,Van S. Hubbard,John M. Jakicic,Robert F. Kushner,Catherine M. Loria,Barbara E. Millen,Cathy Nonas,F. Xavier Pi-Sunyer,June Stevens,Victor J. Stevens,Thomas A. Wadden,Bruce M. Wolfe,Susan Z. Yanovski +18 more
TL;DR: This research presents a state-of-the-art online learning system that automates the very labor-intensive and therefore time-heavy and expensive and expensive process of manually cataloging and cataloging students' academic records.
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The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
Naga Chalasani,Zobair M. Younossi,Joel E. Lavine,Anna Mae Diehl,Elizabeth M. Brunt,Kenneth Cusi,Michael Charlton,Arun J. Sanyal +7 more
TL;DR: This is a practice guideline for clinicians rather than a review article and interested readers can refer to several comprehensive reviews published recently.
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EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease
Giulio Marchesini,Christopher P. Day,Jean-François Dufour,Ali Canbay,Valerio Nobili,Vlad Ratziu,Herbert Tilg,Michael Roden,Amalia Gastaldelli,Hannele Yki-Järvinen,Fritz Schick,Roberto Vettor,Gema Frühbeck,Lisbeth Mathus-Vliegen +13 more
TL;DR: The final purpose is to improve patient care and awareness of the importance of NAFLD, and to assist stakeholders in the decision-making process by providing evidence-based data, which also takes into consideration the burden of clinical management for the healthcare system.