Open AccessDissertation
Trends In Unintentional Drug Overdose-related Deaths
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Opioid Formulations Designed to Resist/Deter Abuse
TL;DR: Three new formulations of opioid analgesics designed to resist or deter abuse are examined, which hold individual promise, but it remains undetermined if they can truly prevent abuse.
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Relative oral bioavailability of morphine and naltrexone derived from crushed morphine sulfate and naltrexone hydrochloride extended-release capsules versus intact product and versus naltrexone solution: A single-dose, randomized-sequence, open-label, three-way crossover trial in healthy volunteers*
TL;DR: The primary aim of this study was to compare the oral bioavailability of naltrexone and its metabolite 6-beta-naltrexol, derived from crushed pellets from MS-sNT capsules, to nALTrexone solution.
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Managing the continuum between pain and dependency in general practice.
TL;DR: Call for increased scrutiny for those with chronic non-malignant pain and introducing UPs for CNMP would systematise attention to the dimension of dependency in the use of COT.
References
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Journal ArticleDOI
Permutation tests for joinpoint regression with applications to cancer rates
TL;DR: A joinpoint regression model is applied to describe continuous changes in the recent trend and the grid-search method is used to fit the regression function with unknown joinpoints assuming constant variance and uncorrelated errors.
Journal ArticleDOI
Association between opioid prescribing patterns and opioid overdose-related deaths.
Amy S.B. Bohnert,Marcia Valenstein,Marcia Valenstein,Matthew J. Bair,Matthew J. Bair,Dara Ganoczy,Dara Ganoczy,John F. McCarthy,John F. McCarthy,Mark A. Ilgen,Mark A. Ilgen,Frederic C. Blow,Frederic C. Blow +12 more
TL;DR: Among patients receiving opioid prescriptions for pain, higher opioid doses were associated with increased risk of opioid overdose death, and receiving both as-needed and regularly scheduled doses was not associated with overdose risk after adjustment.
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Trends in use of opioids for non-cancer pain conditions 2000-2005 in commercial and Medicaid insurance plans: the TROUP study.
Mark D. Sullivan,Mark J. Edlund,Ming Yu Fan,Andrea DeVries,Jennifer Brennan Braden,Bradley C. Martin +5 more
TL;DR: Trends in opioid therapy for NCPC in two disparate populations, one national and commercially insured population (HealthCore plan data) and one state‐based and publicly‐insured population over a six year period (2000–2005), likely represent a broad‐based shift in opioid treatment philosophy.
OPIOIDS, SUBSTANCE ABUSE & ADDICTIONS SECTION Original Research Article Prescription Opioid Abuse and Diversion in an Urban Community: The Results of an Ultrarapid Assessment
TL;DR: The diversion of prescription opioids might be reduced through physician education focusing on recognizing that a patient is misusing and/or diverting prescribed medications; considering a patient's risk for opioid misuse before initiating opioid therapy; and understanding the variation in the abuse potential of different opioid medications currently on the market.
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Prescription opioid abuse and diversion in an urban community: the results of an ultrarapid assessment.
TL;DR: In this paper, a systematic information garnered from prescription drug abusers and dealers on the specific mechanisms of diversion is extremely limited, and comparatively little is known about prescription drug diversion is discussed.