Trifluoroacetic acid: Uses and recent applications in organic synthesis
TL;DR: Trifluoroacetic acid (TFA) has been widely used in organic synthesis as a solvent, catalyst and reagent as discussed by the authors, including rearrangements, functional group deprotections, oxidations, reductions, condensations, hydroarylations and trifluoromethylations.
About: This article is published in Journal of Fluorine Chemistry.The article was published on 2013-12-01. It has received 63 citations till now. The article focuses on the topics: Trifluoroacetic acid & Organic synthesis.
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1,164 citations
TL;DR: In this article, the supply chain to access the necessary raw materials, which is critical for a variety of applications, including pharmaceutical products, is discussed. And the authors propose a solution to this problem.
122 citations
TL;DR: The concentrations of individual PFASs in air, outdoor settled dust, and surface river water decreased exponentially as the distance increases from the FMPs, whereas the concentrations of short-chain perfluoroalkyl carboxylic acids (PFCAs) remained high in the surface water 38 km away.
Abstract: Industrial facilities can be point sources of per- and polyfluoroalkyl substances (PFASs) emission to the surrounding environment. In this study, 25 neutral and ionizable PFASs were analyzed in 94 multimedia samples including air, rain, outdoor settled dust, soil, plant leaves, river water, surface sediment, and shallow groundwater from two fluorochemical manufacturing parks (FMPs) in Fuxin, China, to elucidate the multimedia distribution and transfer pattern of PFASs from a point source. The concentrations of individual PFASs in air, outdoor settled dust, and surface river water decreased exponentially as the distance increases from the FMPs, whereas the concentrations of short-chain (C2-C4) perfluoroalkyl carboxylic acids (PFCAs) remained high (3000 ng/L) in the surface water 38 km away. At FMPs, air concentrations of fluorotelomer alcohols and iodides were found dominant with levels of up to 7900 pg/m3 and 920 pg/m3, respectively. Trifluoroacetic acid was directly released from FMPs and occurred in all the environmental matrices at levels 1-2 orders of magnitude higher than other PFCAs. Higher air-water concentration ratios of short-chain PFCAs (C2-C4) suggested their transfer tendency from air to water. Both short-chain (C2) and long-chain (>C6) PFCAs have greater sediment-water distribution coefficients and deposit dust-air coefficients, which have great influences on the long-range transport potential of different analogues.
112 citations
TL;DR: This reaction not only provides a new protocol for aryl C-H trifluoromethylation, but the generation of CF3· from TFA may prove useful in other contexts and could potentially be extended to other triffluorometHylation reactions.
99 citations
TL;DR: Electrochemical tests show that the initial charge and discharge capacities of the resynthesized LiNi1/3Co 1/3Mn1/ 3O2 are 201 mAh g(-)(1) and 155.4 m Ah g(-1) (2.8-4.5 V, 0.1C), respectively.
92 citations
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TL;DR: In this paper, a methode d'elimination de la silice des eaux geothermiques is proposed. But this methode is not suitable for the extraction of eaux.
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TL;DR: Reactions to make organofluorides that have emerged within the past few years are discussed and which exemplify how to overcome some of the intricate challenges associated with fluorination.
Abstract: Recent advances in catalysis have made the incorporation of fluorine into complex organic molecules easier than ever before, but selective, general and practical fluorination reactions remain sought after. Fluorination of molecules often imparts desirable properties, such as metabolic and thermal stability, and fluorinated molecules are therefore frequently used as pharmaceuticals or materials. But the formation of carbon-fluorine bonds in complex molecules is a significant challenge. Here we discuss reactions to make organofluorides that have emerged within the past few years and which exemplify how to overcome some of the intricate challenges associated with fluorination.
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TL;DR: In this article, an electrospun nonwoven fabric of a cationic polysaccharide, chitosan, was successfully prepared and the effect of the electrospinning solvent and the chitosa concentration on the morphology of the resulting non-woven fabrics was investigated.
Abstract: Summary: An electrospun nonwoven fabric of a cationic polysaccharide, chitosan, was successfully prepared. The present study focuses on the effect of the electrospinning solvent and the chitosan concentration on the morphology of the resulting nonwoven fabrics. The solvents tested were dilute hydrochloric acid, acetic acid, neat formic acid and trifluoroacetic acid. As the chitosan concentration was increased, the morphology of the deposition on the collector changed from spherical beads to interconnected fibrous networks. The addition of dichloromethane to the chitosan-TFA solution improved the homogeneity of the electrospun chitosan fiber. Under optimized conditions, homogenous (not interconnected) chitosan fibers with a mean diameter of 330 nm were prepared.
Effects of the coexisting dichloromethane (MC) in the prespun chitosan-TFA solution on the morphology of the electrospun chitosan fibers. The volume ratio of TFA:MC was 70:30 (×5 000).
620 citations