Tristetraprolin (TTP): interactions with mRNA and proteins, and current thoughts on mechanisms of action.
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TLDR
This review focuses on one of the best characterized ARE binding proteins, tristetraprolin (TTP), the founding member of a small family of CCCH tandem zinc finger proteins, and discusses emerging evidence for TTP operating as a translational regulator.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2013-06-01 and is currently open access. It has received 347 citations till now. The article focuses on the topics: Tristetraprolin & AU-rich element.read more
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A census of human RNA-binding proteins.
TL;DR: This work presents a census of 1,542 manually curated RBPs that are analysed for their interactions with different classes of RNA, their evolutionary conservation, their abundance and their tissue-specific expression, a critical step towards the comprehensive characterization of proteins involved in human RNA metabolism.
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Overview of microRNA biology.
Ashley M. Mohr,Justin L. Mott +1 more
TL;DR: The authors discuss the role of microRNAs in shaping the proteome of the cell in a way that is consistent with microRNA involvement in a highly regulated conversation, sensitive to outside influence and internal feedback.
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Tunable protein synthesis by transcript isoforms in human cells
TL;DR: The results expose the large dynamic range of transcript-isoform- specific translational control, identify isoform-specific sequences that control protein output in human cells, and demonstrate that transcript isoform diversity must be considered when relating RNA and protein levels.
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RNA-binding proteins in immune regulation: a focus on CCCH zinc finger proteins
Mingui Fu,Perry J. Blackshear +1 more
TL;DR: This Review focuses on the emerging roles of CCCH zinc finger proteins in the regulation of immune responses through their effects on cytokine production, immune cell activation and immune homeostasis.
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High-Resolution Sequencing and Modeling Identifies Distinct Dynamic RNA Regulatory Strategies
Michal Rabani,Michal Rabani,Raktima Raychowdhury,Marko Jovanovic,Michael S. Rooney,Michael S. Rooney,Deborah J. Stumpo,Andrea Pauli,Nir Hacohen,Alexander F. Schier,Alexander F. Schier,Perry J. Blackshear,Perry J. Blackshear,Nir Friedman,Ido Amit,Aviv Regev,Aviv Regev +16 more
TL;DR: In this article, the authors used RNA metabolic labeling, rRNA-depleted RNA-seq, and DRiLL, a novel computational framework, to quantify the level; editing sites; and transcription, processing, and degradation rates of each transcript at a splice junction resolution.
References
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A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
Gray D. Shaw,Robert Kamen +1 more
TL;DR: It is proposed that the AU sequences are the recognition signal for an mRNA processing pathway which specifically degrades the mRNAs for certain lymphokines, cytokines, and proto-oncogenes.
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Towards a proteome-scale map of the human protein–protein interaction network
Jean François Rual,Kavitha Venkatesan,Tong Hao,Tomoko Hirozane-Kishikawa,Amélie Dricot,Ning Li,Gabriel F. Berriz,Francis D. Gibbons,Matija Dreze,Nono Ayivi-Guedehoussou,Niels Klitgord,Christophe Simon,Mike Boxem,Stuart Milstein,Jennifer Rosenberg,Debra S. Goldberg,Lan V. Zhang,Sharyl L. Wong,Giovanni Franklin,Siming Li,Joanna S. Albala,Joanna S. Albala,Janghoo Lim,Carlene Fraughton,Estelle Llamosas,Sebiha Cevik,Camille Bex,Philippe Lamesch,Robert S. Sikorski,Jean Vandenhaute,Huda Y. Zoghbi,Alex Smolyar,Stephanie Bosak,Reynaldo Sequerra,Lynn Doucette-Stamm,Michael E. Cusick,David E. Hill,Frederick P. Roth,Marc Vidal +38 more
TL;DR: An initial version of a proteome-scale map of human binary protein–protein interactions is described, which increases by ∼70% the set of available binary interactions within the tested space and reveals more than 300 new connections to over 100 disease-associated proteins.
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Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
TL;DR: Recent advances in understanding of the molecular structures and biochemical functions of the translation initiation machinery are described and key strategies that mediate general or gene-specific translational control are summarized, particularly in mammalian systems.
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Stress granules and processing bodies are dynamically linked sites of mRNP remodeling
Nancy Kedersha,Georg Stoecklin,Maranatha Ayodele,Patrick W. Yacono,Jens Lykke-Andersen,Marvin J. Fritzler,Donalyn Scheuner,Randal J. Kaufman,David E. Golan,Paul A. Anderson +9 more
TL;DR: It is proposed that mRNA released from disassembled polysomes is sorted and remodeled at SGs, from which selected transcripts are delivered to PBs for degradation, an interaction that is promoted by the related mRNA decay factors TTP and BRF1.
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Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies.
Dimitris L. Kontoyiannis,Manolis Pasparakis,Theresa T. Pizarro,Fabio Cominelli,George Kollias +4 more
TL;DR: Development of two specific pathologies in mutant mice, i.e., chronic inflammatory arthritis and Crohn's-like inflammatory bowel disease, suggests that defective function of ARE may be etiopathogenic for the development of analogous human pathologies.