Tropical cyclones and climate change
Summary (2 min read)
1. Introduction:
- Much of their knowledge of gastropod innate immunity has come from investigations of snails that serve as intermediate hosts for the human blood flukes of the genus Schistosoma.
- Schistosomes infect over 200 million people worldwide causing both acute and chronic, debilitating diseases [1, 2].
- There are no effective vaccines against schistosomes, and treatment still relies on a single drug, praziquantel [3].
- As praziquantel resistance can be easily selected in the laboratory [4] and some human populations subjected to mass treatment now show evidence of reduced drug susceptibility [5], alternate control strategies are necessary, including strategies for blocking transmission via the snail intermediate host.
- Understanding the molecular mechanisms of the snail’s internal defense system, especially those mediating resistance to schistosomes (and other helminths), could give valuable clues for developing new strategies to disrupt disease transmission.
2. Insights from non-targeted transcriptomic studies
- Only a limited number have used non-targeted immune gene discovery methods to provide a survey of potentially immune-related genes.
- In addition to usual anticipated candidates such as transcripts coding for enzymes involved in oxidative response or cell adhesion proteins, several unexpected transcripts were identified.
- B. glabrata snails were exposed to various infectious agents such as trematodes [12-14], bacteria [12, 15, 16], or fungi [15], followed by cDNAs analyses using various techniques involving ORESTES or EST sequencing [14], microarrays [12, 13] and NGS technologies [15] in order to identify genes responding to these challenges.
- The potential existence and involvement of a MIF cytokine in B. glabrata immunity was investigated functionally by RNAi knockdown, in which snail MIF protein was shown to exhibit cellular immune activities similar to those of well known mammalian cytokines [17].
- Using a proteomic approach LBP/BPI was identified as a major protein of B. glabrata egg masses [20] and was shown to exhibit a protective its antimicrobial activity [21].
3. Insights from comparisons of susceptible and resistant snail strains
- The low prevalence of snails with patent schistosome infection usually observed in transmission foci [22, 23] raises the possibility that partial innate resistance could exist in natural snail populations.
- Interestingly, previous histological studies showed that hemocytic encapsulation reactions to E. caproni sporocysts occurred between 48 and 72 hours post exposure [28] in resistant snails, corresponding to the timing of hemocyte dermatopontin gene up-regulation.
- One of the more promising immune relevant candidates was a gene cluster displaying similarities to the defense factor Aplysianin A, originally purified from the albumen gland of Aplysia kurodai [33].
- A reverse genetic approach using linkage analysis of polymorphic expressed sequence tags (ESTs) - expressed simple sequence repeats - and previously identified bi-allelic microsatellite markers, genomic (g)SSRs were used, resulting in the identification of putative genomic locations for resistance gene loci [44].
- TEP1 is crucial for phagocytosis of bacteria and killing of Plasmodium parasites in the mosquito Anopheles gambiae.
6. Conclusion:
- Research over the past decade has provided major advances in the field of molluscan immunity, particularly concerning the snail B. glabrata.
- A diversity of experimental systems comprising different strains of B. glabrata and trematode parasites that display various levels of compatibility has clearly shown that the mechanisms underlying the success or failure of parasite development are multigenic and variable among and within populations.
- To date, the contribution of environmental factors as determinant of compatibility between snails and their parasites has probably been underestimated.
- The assembly and annotation of the B. glabrata genome will facilitate continued development of molecular level studies that are likely to provide novel insights important for addressing this important question.
- Therefore, the resolution of a specific interaction between an individual B. glabrata and a particular digenean parasite depends on the integration of numerous individual parameters.
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Frequently Asked Questions (16)
Q2. What are the future works mentioned in the paper "Tropical cyclones and climate change" ?
Additionally, the future changes in climate models such as ENSO and the resulting effects on TC projections are still unclear, given the lack of agreement and poor simulation by many climate models of those climate modes. Analysis of these experiments for changes in TCs has only started156,158,163 and more results will need to be produced before a consensus can emerge on the likely effect of the CMIP5 experimental results on TCs.
Q3. Why is the time-slice method used for TC simulations?
Because of the very significant computational cost of running highresolution coupled ocean–atmosphere GCMs, most very high-resolution simulations of the effect of climate change on TCs have been performed using the time-slice method, whereby simulated SSTs from a coarser-resolution model are used as a boundary condition for the simulation of a finer-resolution atmosphere-only climate model.
Q4. What are the reasons for inconsistent TC projection results?
Inconsistent TC projection results emerge from modeling studies due to different downscaling methodologies and warming scenarios, inconsistencies in projected changes of large-scale conditions, and differences in model physics and tracking algorithms.
Q5. What is the effect of a longer return period on flood levels?
At longer return periods, changes in the frequencies and intensities of TCs play a larger role, and increase the uncertainty in the flood levels for those more extreme events.
Q6. What is the confident prediction of the effects of climate change on TCs?
an increase in storm-relative rainfall rates from composite storms in a warmer climate is one of the more confident predictions of the effects of future climate on TCs.
Q7. What are the main criteria used to determine if a disturbance is a TC?
153,159 Traditional direct detection methods use (1) structural criteria to ensure a disturbance resembles a TC and (2) a wind speed threshold to determine if the disturbance is sufficiently intense to be considered a TC.
Q8. What is the main reason for the parallel creation of more homogeneous datasets?
The parallel creation of more homogeneous satellitederived datasets3 increasingly enables analysis of climate variability for the recent decades.
Q9. What are the factors that are important for societal impacts of TCs?
Note that physical factors like storm size and intensity are difficult for global models to simulate directly unless very fine resolution is used, yet these are factors that are important for societal impacts of TCs, which are largely dominated by the rarer, high-intensity storms.
Q10. What are the proxies of hurricane precipitation in caves?
Other emerging proxies are based on oxygen isotopic ratios of hurricane precipitation in caves (stalagmites), tree rings, and corals.
Q11. How did they find the correlation between TC frequency and CO2?
Using idealized climate experiments, Held and Zhao43 and Sugi et al.129 showed that both the CO2 increase and SST increase contribute about equally to the reduction of future upward mass flux, which they suggested could lead to a reduction of TC frequency.
Q12. What are the main sources of uncertainty in the TC frequency change projections?
Murakami et al.19,160 indicated that there were three major source of uncertainty in the TC frequency change projections: (1) resolution, (2) physics (convection scheme), and (3) SST pattern change.
Q13. How did they estimate the changes in TC tracks in the North Atlantic?
Colbert et al.171 used a statisticaldynamical modeling approach to estimate future changes in TC tracks in the North Atlantic, finding a decrease in westward tracks and in increase in recurving tracks.
Q14. What is the need for a reliable TC detection method for the analysis of climate models?
It is also noted that not all disturbances in the tropics with low-level wind speeds greater than 17ms−1 are TCs (e.g., monsoon gyres196), so there will continue to be a need for a reliable TC detection method for the analysis of climate model output.
Q15. What is the reason that confidence in future regional projections of TCs remains limited?
One of the reasons that confidence in future regional projections of TCs remains limited is the variation between climate models of projections of meanpatterns of change of regional SSTs.
Q16. What are the probable speeds of CDs over the Arabian Sea?
Geetha and Balachandran104 have studied the decadal variations in the translational speeds of cyclonic disturbances (CDs) over the North Indian Ocean over the period 1961–2010 and have noted that during the most recent decade, the most probable speeds of CDs have increased over the Bay of Bengal, but have decreased over the Arabian Sea.