Journal ArticleDOI
Tumor associated macrophages and neutrophils in cancer.
Maria Rosaria Galdiero,Eduardo Bonavita,Isabella Barajon,Cecilia Garlanda,Alberto Mantovani,Sébastien Jaillon +5 more
Reads0
Chats0
TLDR
Macrophages and neutrophils are both integrated in the regulation of the innate and adaptive immune responses in various inflammatory situations, including cancer.About:
This article is published in Immunobiology.The article was published on 2013-11-01. It has received 524 citations till now. The article focuses on the topics: Myeloid-derived Suppressor Cell & Tumor microenvironment.read more
Citations
More filters
Journal ArticleDOI
Epidemiology of Prostate Cancer
TL;DR: There is no evidence yet on how to prevent prostate cancer; however, it is possible to lower the risk by limiting high-fat foods, increasing the intake of vegetables and fruits and performing more exercise.
Journal ArticleDOI
VEGF targets the tumour cell
Hira Lal Goel,Arthur M. Mercurio +1 more
TL;DR: The function of vascular endothelial growth factor in cancer is not limited to angiogenesis and vascular permeability, and the neuropilins are crucial for mediating the effects of VEGF on tumour cells, primarily because of their ability to regulate the function and the trafficking of growth factor receptors and integrins.
Journal ArticleDOI
The Multifaceted Functions of Neutrophils
TL;DR: Primordial neutrophil functions are discussed, and more recent evidence that interactions between neutrophils and adaptive immune cells establish a feed-forward mechanism that amplifies pathologic inflammation is presented.
Journal ArticleDOI
Neutrophils support lung colonization of metastasis-initiating breast cancer cells
TL;DR: It is demonstrated that neutrophil-derived leukotrienes aid the colonization of distant tissues by selectively expanding the sub-pool of cancer cells that retain high tumorigenic potential and the efficacy of using targeted therapy against a specific tumour microenvironment component is revealed.
Journal ArticleDOI
Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer.
Jitka Y. Sagiv,Janna Michaeli,Simaan Assi,Inbal Mishalian,Hen Kisos,Liran Levy,Pazzit Damti,Delphine Lumbroso,Lola Polyansky,Ronit Vogt Sionov,Amiram Ariel,Avi-Hai Hovav,Erik Henke,Zvi G. Fridlender,Zvi Granot +14 more
TL;DR: This work has identified a heterogeneous subset of low-density neutrophils (LDNs) that appear transiently in self-resolving inflammation but accumulate continuously with cancer progression, providing a mechanistic explanation to mitigate the controversy surrounding neutrophil function in cancer.
References
More filters
Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
Journal ArticleDOI
Cancer-related inflammation.
TL;DR: The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
Journal ArticleDOI
Monocyte and macrophage heterogeneity
Siamon Gordon,Philip R. Taylor +1 more
TL;DR: Recent studies have shown that monocyte heterogeneity is conserved in humans and mice, allowing dissection of its functional relevance: the different monocyte subsets seem to reflect developmental stages with distinct physiological roles, such as recruitment to inflammatory lesions or entry to normal tissues.