Journal ArticleDOI
Tumor-derived factors affecting immune cells.
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TLDR
Factors and mechanisms identified in both mouse and human tumors are discussed, and the possibility to associate drugs inhibiting these mechanisms with new immunotherapy strategies already entered in the clinical practice is discussed.About:
This article is published in Cytokine & Growth Factor Reviews.The article was published on 2017-08-01. It has received 23 citations till now. The article focuses on the topics: Tumor microenvironment & Tumor progression.read more
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Structural Features of Galectin-9 and Galectin-1 that Determine Distinct T cell Death Pathways
TL;DR: In this article, the authors defined structural features responsible for distinct activities of the tandem repeat Galectin-9 and dimeric galectin1 and created a series of bivalent constructs with galectins-9, 1, and 1 carbohydrate recognition domains connected by different peptide linkers, finding that the N-terminal carbohydrate recognition domain and linker peptide contributed to the potency of these constructs.
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Current approaches for combination therapy of cancer: The role of immunogenic cell death
Zahra Asadzadeh,Elham Safarzadeh,Sahar Safaei,Ali Baradaran,Ali Mohammadi,Khalil Hajiasgharzadeh,Afshin Derakhshani,Antonella Argentiero,Nicola Silvestris,Behzad Baradaran +9 more
TL;DR: The well-characterized DAMPs are reviewed and focus on the different types of ICD inducers and recent combination therapies that can augment the immunogenicity of cancer cells.
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The Metabolic Mechanisms of Breast Cancer Metastasis.
TL;DR: The role of metabolism in the progression and metastasis of breast cancer is gradually being emphasized as mentioned in this paper, however, the regulatory mechanisms that conduce to cancer metastasis by metabolic reprogramming in breast cancer have not been expounded.
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BET protein targeting suppresses the PD-1/PD-L1 pathway in triple-negative breast cancer and elicits anti-tumor immune response
Guillaume Andrieu,Guillaume Andrieu,Jordan S. Shafran,Charlotte Smith,Anna C. Belkina,Allison N Casey,Naser Jafari,Gerald V. Denis +7 more
TL;DR: It is demonstrated that BET protein targeting represents a promising strategy to overcome tumor-reactive T cell exhaustion and improve anti-tumor immune responses, by reducing the PD-1/PD-L1 axis in triple-negative breast cancer.
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Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy
TL;DR: It is demonstrated that the ‘bilateral tumor model’ was useful for stratifying tumors to investigate the mechanism of unresponsiveness and develop a strategy for proper combination therapy.
References
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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
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Interleukin-10 and the interleukin-10 receptor.
TL;DR: Findings that have advanced the understanding of IL-10 and its receptor are highlighted, as well as its in vivo function in health and disease.
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The immune contexture in human tumours: impact on clinical outcome
Wolf H. Fridman,Franck Pagès,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Jérôme Galon +5 more
TL;DR: In this Opinion article, the context-specific nature of infiltrating immune cells can affect the prognosis of patients is discussed.
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Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
Douglas Hanahan,Lisa M. Coussens +1 more
TL;DR: Most of the hallmarks of cancer are enabled and sustained to varying degrees through contributions from repertoires of stromal cell types and distinctive subcell types, which presents interesting new targets for anticancer therapy.
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Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
Catherine Uyttenhove,Luc Pilotte,Ivan Théate,Ivan Théate,Vincent Stroobant,Didier Colau,Nicolas Parmentier,Thierry Boon,Benoît Van den Eynde +8 more
TL;DR: It is shown that most human tumors constitutively express IDO, and that expression of IDO by immunogenic mouse tumor cells prevents their rejection by preimmunized mice, suggesting that the efficacy of therapeutic vaccination of cancer patients might be improved by concomitant administration of an IDO inhibitor.