Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells
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..., 2008) and increases the number of MDSCs in the spleens of mice carrying LDHA-expressing tumors (Husain et al., 2013)....
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...Furthermore, Husain et al. reported reduced numbers of myeloid-derived suppressor cells (MDSCs) in the spleens of mice carrying Ldha-depleted tumors (Husain et al., 2013)....
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...Since tumors expressing high levels of Ldha modulate immune cell infiltration and differentiation in the spleens of tumor-bearing mice (Husain et al., 2013), we analyzed myeloid and lymphoid cells in the blood and spleen of tumor-bearing C57BL/6 mice....
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...reported reduced numbers of myeloid-derived suppressor cells (MDSCs) in the spleens of mice carrying Ldha-depleted tumors (Husain et al., 2013)....
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...Since tumors expressing high levels of Ldha modulate immune cell infiltration and differentiation in the spleens of tumor-bearing mice (Husain et al., 2013), we analyzed myeloid and lymphoid cells in the blood and spleen of tumor-bearing C57BL/6 mice....
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...The presence of excess lactate can also enhance the functions of immunosuppressive cells, such as myeloid subsets, and polarize macrophages to an immunosuppressive phenotype (Colegio et al., 2014; Husain et al., 2013)....
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Cites background from "Tumor-Derived Lactate Modifies Anti..."
...Lactate also inhibits natural killer cell function directly by inhibiting cytolytic function and indirectly by increasing the numbers of myeloid-derived suppressor cells that inhibit natural killer cytotoxicity (176)....
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