Tumor heterogeneity: causes and consequences
Andriy Marusyk,Kornelia Polyak +1 more
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TLDR
This work summarizes the sources of intra-tumor phenotypic heterogeneity with emphasis on genetic heterogeneity and reviews experimental evidence for the existence of both intra-Tumor clonal heterogeneity as well as frequent evolutionary divergence between primary tumors and metastatic outgrowths.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2010-01-01 and is currently open access. It has received 1409 citations till now. The article focuses on the topics: Genetic heterogeneity.read more
Citations
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Clonal evolution in cancer
Mel Greaves,Carlo C. Maley +1 more
TL;DR: The inherently Darwinian character of cancer is the primary reason for this therapeutic failure, but it may also hold the key to more effective control.
Journal ArticleDOI
Intra-tumour heterogeneity: a looking glass for cancer?
TL;DR: This Review discusses both genetic and non-genetic causes of phenotypic heterogeneity of tumour cells, with an emphasis on heritable phenotypes that serve as a substrate for clonal selection and the implications of intra-tumour heterogeneity in diagnostics and the development of therapeutic resistance.
Journal ArticleDOI
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
Andrea Sottoriva,Andrea Sottoriva,Andrea Sottoriva,Inmaculada Spiteri,Sara Grazia Maria Piccirillo,Anestis Touloumis,V. Peter Collins,John C. Marioni,Christina Curtis,Colin Watts,Simon Tavaré,Simon Tavaré,Simon Tavaré +12 more
TL;DR: The genome-wide architecture of intratumor variability in GB is revealed across multiple spatial scales and patient-specific patterns of cancer evolution, with consequences for treatment design.
Journal ArticleDOI
Cells of origin in cancer
TL;DR: Evidence is also accumulating that cancers of distinct subtypes within an organ may derive from different 'cells of origin', and the identification of these crucial target cell populations may allow earlier detection of malignancies and better prediction of tumour behaviour.
Journal ArticleDOI
Immune evasion in cancer: Mechanistic basis and therapeutic strategies
Dass S. Vinay,Elizabeth P. Ryan,Graham Pawelec,Wamidh H. Talib,John Stagg,Eyad Elkord,Terry Lichtor,William K. Decker,Richard L. Whelan,H. M. C. Shantha Kumara,Emanuela Signori,Kanya Honoki,Alexandros G. Georgakilas,Amr Amin,William G. Helferich,Chandra S. Boosani,Gunjan Guha,Maria Rosa Ciriolo,Sophie Chen,Sulma I. Mohammed,Asfar S. Azmi,W. Nicol Keith,Alan Bilsland,Dipita Bhakta,Dorota Halicka,Hiromasa Fujii,Katia Aquilano,S. Salman Ashraf,Somaira Nowsheen,Xujuan Yang,Beom K. Choi,Byoung S. Kwon +31 more
TL;DR: The advances made toward understanding the basis of cancer immune evasion are discussed, the efficacy of various therapeutic measures and targets that have been developed or are being investigated to enhance tumor rejection are summarized and some natural agents and phytochemicals merit further study.
References
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The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Book
The Evolution of Cooperation
TL;DR: In this paper, a model based on the concept of an evolutionarily stable strategy in the context of the Prisoner's Dilemma game was developed for cooperation in organisms, and the results of a computer tournament showed how cooperation based on reciprocity can get started in an asocial world, can thrive while interacting with a wide range of other strategies, and can resist invasion once fully established.
Journal ArticleDOI
The Evolution of Cooperation
R. B. Greene,Robert Axelrod +1 more
TL;DR: A model is developed based on the concept of an evolutionarily stable strategy in the context of the Prisoner's Dilemma game to show how cooperation based on reciprocity can get started in an asocial world, can thrive while interacting with a wide range of other strategies, and can resist invasion once fully established.
Journal ArticleDOI
Prospective identification of tumorigenic breast cancer cells
Muhammad Al-Hajj,Max S. Wicha,Adalberto Benito-Hernandez,Sean J. Morrison,Sean J. Morrison,Michael F. Clarke +5 more
TL;DR: The ability to prospectively identify tumorigenic cancer cells will facilitate the elucidation of pathways that regulate their growth and survival and strategies designed to target this population may lead to more effective therapies.
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The Neutral Theory of Molecular Evolution
TL;DR: The neutral theory as discussed by the authors states that the great majority of evolutionary changes at the molecular level are caused not by Darwinian selection but by random drift of selectively neutral mutants, which has caused controversy ever since.
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