Tumor Necrosis Factor-α Signaling in Macrophages
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Cites background from "Tumor Necrosis Factor-α Signaling i..."
...Because of its unique ability to orchestrate downstream cytokine cascade, TNF-α is considered to be a “master regulator” of inflammatory cytokine production [37], while the important regulatory role of IL-1 in inflammation is widely accepted as well....
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...TNF-α is a 17 kDa protein that is not only derived predominantly from activated immune cells (macrophages) but also from nonimmune cells (fibroblasts) in response to invasive, infectious, or inflammatory stimuli [37, 40]....
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515 citations
Cites background from "Tumor Necrosis Factor-α Signaling i..."
...Since TNFα is mainly secreted by macrophages [99], the effect of allicin on macrophages was examined with respect to how allicin influences the expression of TNFα itself....
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340 citations
References
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