Tumour exosome integrins determine organotropic metastasis
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...Cancer cell–derived exosomes are also proposed to play a role in organotropic metastasis of breast and pancreatic cancers, in part through integrin expression on exosomes and organ-specific proinflammatory responses (157), and the delivery of exosomal EGFR from gastric cancer cells to Kupffer cells and hepatic stellate cells promotes liver-specific metastasis through enhanced HGF (hepatocyte growth factor) signaling in the liver (158)....
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...Interestingly, sEVs from different tumor types bear integrins (ITGs) that target these sEVs to specific organs and trigger signaling pathways, thereby initiating pre-metastatic niche formation (Hoshino et al., 2015)....
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...For example, sEVs expressing ITGavb5 bind specifically to Kupffer cells, mediating liver tropism, while ITGa6b4 and ITGa6b1 on sEVs bind to lung-resident fibroblasts and epithelial cells, leading to lung tropism (Hoshino et al., 2015)....
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...(Peinado et al., 2012; Zhou et al., 2014) or by conditioning pre-metastatic sites in distant organs (Costa-Silva et al., 2015; Hoshino et al., 2015; Peinado et al., 2012)....
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..., 2014) or by conditioning pre-metastatic sites in distant organs (Costa-Silva et al., 2015; Hoshino et al., 2015; Peinado et al., 2012)....
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...Integrins on tumor exosomes have been reported to predict organ-specific metastasis (Hoshino et al., 2015)....
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