Book ChapterDOI
Tunable Protein Hydrogels: Present State and Emerging Development.
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TLDR
The use of multi-block design further expands the customizability of protein hydrogels as discussed by the authors and has been widely used in medical treatment, skin care, artificial organs and wearable electronic devices.Abstract:
In recent years, protein and peptide-based hydrogels have received great attention for applications in biomedicine. Compared to hydrogels based on synthetic materials, they have the decisive advantages of being biological origin, providing cells with a more in vivo-like microenvironment and possessing potential biological activity. Empowered by the steadily deepened understanding of the sequence-structure-function relationship of natural proteins and the rapid development of molecular-biological tools for accurate protein sequence editing, researchers have developed a series of recombinant proteins as building blocks and responsive blocks to design novel functional hydrogels. The use of multi-block design further expands the customizability of protein hydrogels. With the improvement of standardization of preparation and testing methods, protein hydrogels are expected to be widely used in medical treatment, skin care, artificial organs and wearable electronic devices. More recently, the emergence of catalytically active protein hydrogel brings new opportunities for applications of protein hydrogels. It is believed that through integrated approaches of engineering biology and materials sciences novel and hereto unthinkable protein hydrogels and properties may be generated for applications in areas beyond medicine and health, including biotechnology, food and agriculture, and even energy.read more
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Journal ArticleDOI
Diversity of Bioinspired Hydrogels: From Structure to Applications
TL;DR: In this paper , the main advantages of the presence of biomolecules (polysaccharides, proteins, and polypeptides) in hydrogels are discussed, including drug delivery, self-healing materials for regenerative medicine, cell culture, wound dressings, 3D bioprinting, foods, etc.
Journal ArticleDOI
Protein-Based Hydrogels and Their Biomedical Applications
TL;DR: Protein hydrogels made from proteins are attractive materials for diverse medical applications, as they are biocompatible, biodegradable, and amenable to chemical and biological modifications as discussed by the authors .
References
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Journal ArticleDOI
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Silk-based biomaterials
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TL;DR: The majority of examples, discussed in this paper, deal with pH-responsive drug delivery system, and Thermo-responsive polymer is also covered to a large extent, as well as double-responsive system.
Journal ArticleDOI
Designing hydrogels for controlled drug delivery.
Jianyu Li,David J. Mooney +1 more
TL;DR: This Review discusses how different mechanisms interact and can be integrated to exert fine control in time and space over the drug presentation, and collects experimental release data from the literature and presents quantitative comparisons between different systems to provide guidelines for the rational design of hydrogel delivery systems.
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