Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
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Cites background or methods from "Twist, a Master Regulator of Morpho..."
...…traits, we induced an EMT in nontumorigenic, immortalized human mammaryepithelial cells (HMLEs) by ectopic expression of either the Twist or Snail transcription factors, both of which are capable of inducing EMTs in epithelial cells (Batlle et al., 2000; Cano et al., 2000; Yang et al., 2004, 2006)....
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...…confer malignant traits, such as motility, invasiveness, and resistance to apoptosis, on neoplastic cells (Cheng et al., 2007; Comijn et al., 2001; Hartwell et al., 2006; Huber et al., 2005; Mani et al., 2007; Oft et al., 2002; Peinado et al., 2007; Savagner et al., 2005; Yang et al., 2004, 2006)....
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...Reverse Transcriptase PCR Analysis SYBR-Green real-time RT-PCR and the corresponding data analysis were described earlier (Yang et al., 2004)....
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3,863 citations
Cites background from "Twist, a Master Regulator of Morpho..."
...In a recent study of genes involved in lung metastasis of a mouse mammary tumor cell line, enhanced expression of Twist—a transcription factor that promotes EMT transitions—was found to favor metastasis due to its ability to augment the rate of hematogenous intravasation (Yang et al., 2004)....
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...togenous intravasation (Yang et al., 2004)....
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3,804 citations
3,640 citations
Cites background from "Twist, a Master Regulator of Morpho..."
...Several studies using in vivo mouse-model systems have suggested that EMT is involved in breast cancer metastasi...
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References
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"Twist, a Master Regulator of Morpho..." refers background in this paper
...Such EMT is suggested to contribute to the dissemination of carcinoma cells fromthat 4T1 cells are able to complete intravasation and to survive anoikis due to loss of cell-matrix attachment. epithelial tumors (Thiery, 2002)....
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5,860 citations
5,132 citations
"Twist, a Master Regulator of Morpho..." refers background in this paper
...To test whether thesebreast cancers and melanomas and can elicit chemotacsiRNAs could suppress Twist expression in 4T1 cells,tic and invasive responses (Muller et al., 2001)....
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4,319 citations
"Twist, a Master Regulator of Morpho..." refers background in this paper
...…at distal sites.75230 Paris Cedex 05 Finally, in the new host environment, an even smallerFrance subset of such metastasizing cells succeeds in prolifer-5 EMI 0229 INSERM ating from minute growths (micrometastases) into malig-CRLC Val d’Aurelle-Paul Lamarque nant, secondary tumors (Fidler, 2003)....
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