Two-Dose Intrapartum/Newborn Nevirapine and Standard Antiretroviral Therapy to Reduce Perinatal HIV Transmission
Citations
2,958 citations
Cites background from "Two-Dose Intrapartum/Newborn Nevira..."
...Perinatal transmission rates can be reduced to <2% with universal screening of pregnant women in combination with prophylactic administration of antenatal antiretroviral drugs.(28)...
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642 citations
Cites background from "Two-Dose Intrapartum/Newborn Nevira..."
...4% among women in the nevirapine group (69)....
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...For women in the United States, Europe, Brazil, and the Bahamas receiving antenatal antiretroviral therapy, addition of the 2-dose nevirapine regimen did not result in lower transmission rates (69)....
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...Given lack of further reduction of transmission with nevirapine added to an established regimen (69) and the potential development of resistance, addition of nevirapine during labor for women already receiving antiretroviral therapy is not recommended....
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...Results of epidemiologic and clinical trials suggest that women receiving highly active antiretroviral regimens that effectively reduce HIV-1 RNA to <1,000 copies/mL or undetectable levels have very low rates of perinatal transmission (27,61,69,88)....
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542 citations
536 citations
Cites background from "Two-Dose Intrapartum/Newborn Nevira..."
...Given lack of further reduction of transmission with nevirapine added to an established regimen [83] and the potential development of resistance, addition of nevirapine during labor for women already receiving antiretroviral therapy is not recommended....
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...For women in the United States, Europe, Brazil, and the Bahamas receiving antenatal antiretroviral therapy, addition of the 2–dose nevirapine regimen did not result in lower transmission rates [83]....
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...Results of epidemiologic and clinical trials suggest that women receiving highly active antiretroviral regimens that effectively reduce HIV-1 RNA to <1,000 copies/mL or undetectable levels have very low rates of perinatal transmission [25, 66, 83, 102]....
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...4% among women in the nevirapine group [83]....
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496 citations
Additional excerpts
...Village of Mochudi 42/170 (25) 50/285 (18) 44/275 (16)...
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...Neutropenia 34/156 (22) 43/283 (15) 49/270 (18)...
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...Town of Lobatse 31/170 (18) 53/285 (19) 52/275 (19)...
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...$101–$200 31/170 (18) 34/285 (12) 38/275 (14)...
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References
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"Two-Dose Intrapartum/Newborn Nevira..." refers background in this paper
...In HIVNET 012, the resistance mutations detected during the early postpartum period were not apparent when the women were tested at later time points.(24) In a substudy of women participating in PACTG 316 who had active viral replication, new nevirapineresistance mutations were demonstrated in 15% (95% confidence interval, 8%-23%), suggesting that risk of new nevirapine-resistance mutations may occur even in women receiving other ART....
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388 citations
381 citations
"Two-Dose Intrapartum/Newborn Nevira..." refers background or methods or result in this paper
...The results of the Pediatric AIDS [acquired immunodeficiency syndrome] Clinical Trials Group (PACTG) 076, published in 1994, offered proof of the concept that a zidovudine regimen given antepartum, intrapartum, and to the newborn for 6 weeks could significantly reduce HIV transmission.(3) Implementation of this regimen in the developed world has reduced transmission rates of perinatal HIV to between 5% and 8%....
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...natal HIV transmission is high ( 25%).(3) Two African trials have shown that the 2-dose nevirapine regimen is effective in reducing transmission in women who have not received antenatal ART....
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...Women were encouraged to receive the PACTG 076 zidovudine regimen as a minimum therapy.(3)...
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