Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
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Cites background from "Two subsets of memory T lymphocytes..."
...8% of CD3 + CD8 + cells in DIO mice), suggesting the majority of infiltrated CD8 + T cells were activated effector T cell...
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Cites background or methods from "Two subsets of memory T lymphocytes..."
...Although the biology and pharmacology of CCR6 are not yet developed, it is predicted to be important in memory T cell and dendritic cell trafficking to secondary lymphoid organs....
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...HBD2 is produced by epithelial cells during infection and functions as a direct antimicrobial factor but also chemoattracts CCR61 dendritic cells and memory T cells, suggesting a chemokine receptor link between innate and adaptive immunity (Yang et al., 1999b)....
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...The CCR6 ligand MIP-3a appears to specifically regulate constitutive homing of Langerhans-type dendritic cells to the epidermis, whereas other types of dendritic cells respond to multiple other chemokines (Charbonnier et al., 1999)....
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...After T cell receptor (TCR) stimulation, CXCR5 is up-regulated on memory/effector T cells, whereas IL-2 causes down-regulation (Sallusto et al., 1999b)....
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...159 A. CCR1. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 159 B. CCR2. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 160 C. CCR3. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 161 D. CCR4. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 162 E. CCR5. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 162 F. CCR6. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 164 G. CCR7. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 164 H. CCR8. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 165 I. CCR9. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 165 J. CCR10. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....
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References
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Additional excerpts
...BIOGEN 34 38 5 Originally published as Nature 401 , 708 – 712 ; 1999 Naive T lymphocytes travel to T-cell areas of secondary lymphoid organs in search of antigen presented by dendritic cell...
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"Two subsets of memory T lymphocytes..." refers background in this paper
..., whereas protective responses in the tissues are mediated by T cells that produce effector cytokines, such as interferon-γ (IFN-γ) or interleukin-4 (IL-4), or release stored perfori...
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2,925 citations
Additional excerpts
...BIOGEN 34 38 5 Originally published as Nature 401 , 708 – 712 ; 1999 Naive T lymphocytes travel to T-cell areas of secondary lymphoid organs in search of antigen presented by dendritic cell...
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"Two subsets of memory T lymphocytes..." refers background in this paper
...This migration mediates rapid protective responses and is controlled by the expression of different sets of integrins and chemokine receptor...
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"Two subsets of memory T lymphocytes..." refers background in this paper
...A fraction of primed T lymphocytes persists as circulating memory cells that can confer protection and give, upon secondary challenge, a qualitatively different and quantitatively enhanced respons...
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