Journal ArticleDOI
Types of myocardial injury and mid-term outcomes in patients with COVID-19.
Annapoorna Kini,Davide Cao,Matteo Nardin,Matteo Nardin,Samantha Sartori,Zhongjie Zhang,Carlo Andrea Pivato,Carlo Andrea Pivato,Mauro Chiarito,Mauro Chiarito,Johny Nicolas,Yuliya Vengrenyuk,Parasuram Krishnamoorthy,Samin K. Sharma,George Dangas,Valentin Fuster,Roxana Mehran +16 more
Reads0
Chats0
TLDR
In this paper, the authors evaluated the acute and chronic patterns of myocardial injury among patients with coronavirus disease-2019 (COVID-19), and their mid-term outcomes.Abstract:
AIMS: To evaluate the acute and chronic patterns of myocardial injury among patients with coronavirus disease-2019 (COVID-19), and their mid-term outcomes. METHODS AND RESULTS: Patients with laboratory-confirmed COVID-19 who had a hospital encounter within the Mount Sinai Health System (New York City) between 27 February 2020 and 15 October 2020 were evaluated for inclusion. Troponin levels assessed between 72 h before and 48 h after the COVID-19 diagnosis were used to stratify the study population by the presence of acute and chronic myocardial injury, as defined by the Fourth Universal Definition of Myocardial Infarction. Among 4695 patients, those with chronic myocardial injury (n = 319, 6.8%) had more comorbidities, including chronic kidney disease and heart failure, while acute myocardial injury (n = 1168, 24.9%) was more associated with increased levels of inflammatory markers. Both types of myocardial injury were strongly associated with impaired survival at 6 months [chronic: hazard ratio (HR) 4.17, 95% confidence interval (CI) 3.44-5.06; acute: HR 4.72, 95% CI 4.14-5.36], even after excluding events occurring in the first 30 days (chronic: HR 3.97, 95% CI 2.15-7.33; acute: HR 4.13, 95% CI 2.75-6.21). The mortality risk was not significantly different in patients with acute as compared with chronic myocardial injury (HR 1.13, 95% CI 0.94-1.36), except for a worse prognostic impact of acute myocardial injury in patients <65 years of age (P-interaction = 0.043) and in those without coronary artery disease (P-interaction = 0.041). CONCLUSION: Chronic and acute myocardial injury represent two distinctive patterns of cardiac involvement among COVID-19 patients. While both types of myocardial injury are associated with impaired survival at 6 months, mortality rates peak in the early phase of the infection but remain elevated even beyond 30 days during the convalescent phase.read more
Citations
More filters
Journal ArticleDOI
Long COVID and the cardiovascular system—elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial and Pericardial Diseases
Mariann Gyöngyösi,Pilar Alcaide,Folkert W. Asselbergs,Bianca J. J. M. Brundel,Giovanni G. Camici,Paula A. da Costa Martins,Péter Ferdinandy,Marianna Fontana,Henrique Girão,Massimiliano Gnecchi,Can Gollmann-Tepeköylü,Petra Kleinbongard,Thomas Krieg,Rosalinda Madonna,M. Paillard,Antonis Pantazis,R. Perrino,Maurizio Pesce,Gabriele G. Schiattarella,Joost P.G. Sluijter,Sabine Steffens,Carsten Tschöpe,Sophie Van Linthout,Sean M. Davidson +23 more
TL;DR: In this article , the authors aim to provide insight into the possible causes and therapeutic options available for the cardiovascular manifestations of long COVID, including chronic fatigue, chest pain, ECG abnormalities, postural orthostatic tachycardia, or newly developed supraventricular or ventricular arrhythmias.
Journal ArticleDOI
Myocardial Injury in COVID-19 and Its Implications in Short- and Long-Term Outcomes
A Izquierdo-Marquisa,Hector Cubero-Gallego,Álvaro Aparisi,Beatriz Vaquerizo,Núria Ribas-Barquet +4 more
TL;DR: It is suggested that myocardial injury would identify COVID-19 patients with higher risk during active infection and mid-term follow-up and the optimal screening tool for residual cardiac sequelae, clinical follow- up, and the benefits of a specific cardiovascular therapy during the convalescent phase remains unknown.
Journal ArticleDOI
Heart failure during the COVID‐19 pandemic: clinical, diagnostic, management, and organizational dilemmas
Alberto Palazzuoli,Marco Metra,Sean P. Collins,Marianna Adamo,Andrew P. Ambrosy,Laura Antohi,Tuvia Ben Gal,Dimitrios Farmakis,Finn Gustafsson,Loreena Hill,Yuri Lopatin,Francesco Tramonte,Alexander R. Lyon,Josep Masip,Òscar Miró,Brenda Moura,Wilfried Mullens,Razvan I. Radu,Magdy Abdelhamid,Stefan D. Anker,Ovidiu Chioncel +20 more
TL;DR: Recent advances regarding the relationships between HF and COVID-19 pandemic with respect to epidemiology, pathogenetic mechanisms, and differential diagnosis are examined.
Journal ArticleDOI
Cardiac Manifestations of Post-Acute COVID-19 Infection
TL;DR: In this paper , the authors found that the post-acute and chronic phases of COVID-19 infection are associated with various significant cardiovascular sequelae including direct myocardial injury, arrhythmias, and cardiomyopathies.
Journal ArticleDOI
Myocardial Injury Portends a Higher Risk of Mortality and Long-Term Cardiovascular Sequelae after Hospital Discharge in COVID-19 Survivors
Riccardo Rinaldi,Mattia Basile,Carmine Salzillo,Domenico Grieco,A. Caffè,Carlotta Masciocchi,Livia Lilli,Andrea Damiani,G. La Vecchia,Giuliana Iannaccone,Alice Bonanni,Gennaro De Pascale,Rita Murri,Massimo Fantoni,Giovanna Liuzzo,Tommaso Sanna,Massimo Massetti,Antonio Gasbarrini,Vincenzo Valentini,Massimo Antonelli,Filippo Crea,Rocco A. Montone,On Behalf Of The Gemelli Against Covid Group +22 more
TL;DR: In CO VID-19 survivors, myocardial injury during the hospital stay portends a higher risk of mortality and cardiovascular sequelae and could be considered for the risk stratification of COVID-19 sequelae in patients who are successfully discharged.
References
More filters
Journal ArticleDOI
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
Journal ArticleDOI
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
Journal ArticleDOI
An interactive web-based dashboard to track COVID-19 in real time.
TL;DR: The outbreak of the 2019 novel coronavirus disease (COVID-19) has induced a considerable degree of fear, emotional stress and anxiety among individuals around the world.
Journal ArticleDOI
Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China.
Shaobo Shi,Mu Qin,Bo Shen,Yuli Cai,Tao Liu,Fan Yang,Wei Gong,Xu Liu,Jinjun Liang,Qinyan Zhao,He Huang,Bo Yang,Congxin Huang +12 more
TL;DR: The association between cardiac injury and mortality in patients with COVID-19 was analyzed and it was found that patients with cardiac injury had a higher proportion of multiple mottling and ground-glass opacity in radiographic findings than those without cardiac injury.
Related Papers (5)
Prevalence and Impact of Myocardial Injury in Patients Hospitalized With COVID-19 Infection.
Anuradha Lala,Anuradha Lala,Kipp W. Johnson,James L. Januzzi,Adam Russak,Ishan Paranjpe,Felix Richter,Shan Zhao,Sulaiman Somani,Tielman Van Vleck,Akhil Vaid,Fayzan Chaudhry,Jessica K De Freitas,Zahi A. Fayad,Sean Pinney,Matthew A. Levin,Alexander W. Charney,Emilia Bagiella,Jagat Narula,Benjamin S. Glicksberg,Girish N. Nadkarni,Donna M. Mancini,Valentin Fuster +22 more