Journal ArticleDOI
Über Steroide. 129. Mitteilung. Bildung von 18- und 19-Oxy-cortexon durch Einwirkung von Nebennieren-Homogenaten auf Cortexon
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By aerobic incubation of Cortexone with homogenates of beef adrenals the new 18-Hydroxy-cortexone as well as the already known 19-hydroxy-compound are obtained and the implications of the presence of an 18-hydroxylase for the postulated course of biosynthesis of aldosterone in vitro are discussed.Abstract:
By aerobic incubation of Cortexone with homogenates of beef adrenals the new 18-hydroxy-cortexone as well as the already known 19-hydroxy-compound are obtained. The implications of the presence of an 18-hydroxylase for the postulated course of biosynthesis of aldosterone in vitro are discussed.read more
Citations
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The effect of acth, renin, angiotensin ii, and various precursors on biosynthesis of aldosterone by adrenal slices
Norman M Kaplan,F. C. Barter +1 more
TL;DR: It will be shown that angiotensin II, like ACTH, does have such a direct effect, and renin does not, when compared with the effect of various precursors on the biosynthesis of aldosterone.
Journal ArticleDOI
The Identification of the Porter-Silber Chromogen Secreted by the Rat Adrenal
TL;DR: Evidence is presented strongly suggesting that the unknown compound is the 20 ---f 18 cyclic hemiketal of 1% hydroxy-11-deoxycorticosterone, a steroid with a A4-3-ketone function but no ketone group at Cl1 and C17.
Journal ArticleDOI
Biosynthesis of steroid hormones
TL;DR: The different pathways of biosynthesis are described, by which steroid hormones are produced in vivo in the gonads, the adrenal cortex and the placenta, or in vitro by corresponding tissue preparations, and compounds which block one or other of the biosynthetic steps are discussed.
Journal ArticleDOI
Isolierung und Konstitutionsermittlung weiterer Pregnanverbindungen aus Nebennieren. Über Steroide, 144. Mitteilung
R. Neher,Albert Wettstein +1 more
TL;DR: Nine additional compounds of the pregnane series have been isolated from adrenals and elucidation of their constitution showed that four are known compounds, but five are new.
References
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Journal ArticleDOI
[Constitution of aldosterone, a new mineralocorticoid].
S. A. Simpson,S. A. Simpson,J. F. Tait,J. F. Tait,Albert Wettstein,Albert Wettstein,R. Neher,R. Neher,Von Euw J,Von Euw J,O. Schindler,O. Schindler,T. Reichstein,T. Reichstein +13 more
TL;DR: Aldosterone as mentioned in this paper was suggested as a definitive name for the new crystalline mineralocorticoid provisionally called electrocortin and showed that this compound is 11β, 21dihydroxy-3, 20diketo-4pregnen-18-al.
Journal ArticleDOI
Die Konstitution des Aldosterons. Über Bestandteile der Nebennierenrinde und verwandte Stoffe. 92. Mitteilung
S. A. Simpson,S. A. Simpson,J. F. Tait,J. F. Tait,Albert Wettstein,Albert Wettstein,R. Neher,R. Neher,J. v. Euw,J. v. Euw,O. Schindler,O. Schindler,T. Reichstein,T. Reichstein +13 more
TL;DR: Aldosteron (C21H28O5) nr. 876 (XI), sein Acetylderivat Nr.882 (XII) and den aus 3-Keto-methylester Nr., 877 (XIX) charakterisiert.
Journal ArticleDOI
19-Hydroxylation of delta 4-Androstene-3,17-dione and dehydroepiandrosterone by bovine adrenals.
TL;DR: In this article, aufklarung der Struktur von 19-Oxy-Δ4-androsten-3,17-dion (VI), einer Substanz, isoliert nach Inkubation von Δ4-Androsten 3,17dion and von Dehydroepiandrosteron with einem Rinder-Nebennieren-Homogenat, ist beschrieben.