Journal ArticleDOI
Ultrasound-mediated topical delivery of econazole nitrate with potential for treating Raynaud's phenomenon.
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TLDR
The ultrasound-assisted transdermal delivery of F2_HPMC dispersion could be further studied as a new therapy for Raynaud's phenomenon.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2020-03-14. It has received 5 citations till now. The article focuses on the topics: Econazole & Econazole Nitrate.read more
Citations
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Roles of Lipids in the Permeability Barriers of Skin and Oral Mucosa
TL;DR: In the oral cavity, the regions of the gingiva and hard palate are covered by keratinized epithelia that much resemble the epidermis as discussed by the authors, which can prevent the penetration of potentially toxic substances, including microbial products.
Journal ArticleDOI
Physical Enhancement? Nanocarrier? Current Progress in Transdermal Drug Delivery
TL;DR: Transdermal drug delivery systems (TDDS) as mentioned in this paper is a method that provides drug adsorption via the skin, which can replace conventional oral administration and blood administration, however, it is still difficult to design efficient TDDS due to the high barrier property of skin covered with stratum corneum.
Journal ArticleDOI
Ultrasound technology and biomaterials for precise drug therapy
TL;DR: In this article , a review of the application of ultrasound-functional biomaterials for drug precision therapy is presented, and key information such as effective ultrasonic intensity and frequency parameter range, types of loaded drugs, systematic therapeutic effect, and so on for precision therapy with an advanced combination of ultrasonic technology and various biological materials are expounded and summarized.
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Simultaneous Delivery of Econazole, Terbinafine and Amorolfine with Improved Cutaneous Bioavailability: A Novel Micelle-Based Antifungal “Tri-Therapy”
TL;DR: A micelle-based antifungal formulation containing econazole, terbinafine and amorolfine using D-α-tocopheryl polyethylene glycol succinate for simultaneous cutaneous delivery of three agents with complementary mechanisms of action shows promising results.
Journal ArticleDOI
Topical delivery of gambogic acid assisted by the combination of low-frequency ultrasound and chemical enhancers for chemotherapy of cutaneous melanoma
TL;DR: In this paper, a combination of chemical enhancers (EN: azone and propylene glycol) and physical ultrasound (US) was used to improve the percutaneous permeation of GA and enhance the anti-melanoma activity.
References
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Journal ArticleDOI
Transdermal drug delivery
Mark R. Prausnitz,Robert Langer +1 more
TL;DR: Third-generation delivery systems target their effects to skin's barrier layer of stratum corneum using microneedles, thermal ablation, microdermabrasion, electroporation and cavitational ultrasound for delivery of macromolecules and vaccines.
Journal ArticleDOI
The menthol receptor TRPM8 is the principal detector of environmental cold
Diana M. Bautista,Jan Siemens,Joshua M. Glazer,Pamela R. Tsuruda,Allan I. Basbaum,Cheryl L. Stucky,Sven-Eric Jordt,David Julius +7 more
TL;DR: It is shown that cultured sensory neurons and intact sensory nerve fibres from TRPM8-deficient mice exhibit profoundly diminished responses to cold, validating the hypothesis that TRP channels are the principal sensors of thermal stimuli in the peripheral nervous system.
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TRPM8 Is Required for Cold Sensation in Mice
Ajay Dhaka,Amber N. Murray,Jayanti Mathur,Taryn J. Earley,Matt Petrus,Ardem Patapoutian,Ardem Patapoutian +6 more
TL;DR: It is shown that TRPM8 mediates the analgesic effect of moderate cooling after administration of formalin, a painful stimulus, and contributes to sensing unpleasant cold stimuli or mediating the effects of cold analgesia.
Journal ArticleDOI
Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the Stratum Corneum
TL;DR: The progress and current status of the transdermal drug delivery field is detailed, numerous pharmaceutical developments which have been employed to overcome limitations associated with skin delivery systems are described and particular attention is paid to the emerging field of microneedle technologies.
Journal ArticleDOI
Approaches for breaking the barriers of drug permeation through transdermal drug delivery.
Amit Alexander,Shubhangi Dwivedi,Ajazuddin,Tapan Kumar Giri,Swarnlata Saraf,Shailendra Saraf,Dulal Krishna Tripathi +6 more
TL;DR: This review focuses on the recent advancements in the TDDS which include iontophoresis, sonophores is, electroporation, microneedles, magnetophoreis, photomechanical waves and electron beam irradiation.
Related Papers (5)
Comparison of Xeroradiographic and Ultrasound Detection of Corticosteroid Induced Dermal Thinning
The effects of equine skin preparation on transdermal drug penetration in vitro.
Paul C. Mills,Sheree E. Cross +1 more