Journal ArticleDOI
Ultrasound-mediated transdermal protein delivery.
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TLDR
Low-frequency ultrasound was shown to increase the permeability of human skin to many drugs, including high molecular weight proteins, by several orders of magnitude, thus making transdermal administration of these molecules potentially feasible.Abstract:
Transdermal drug delivery offers a potential method of drug administration. However, its application has been limited to a few low molecular weight compounds because of the extremely low permeability of human skin. Low-frequency ultrasound was shown to increase the permeability of human skin to many drugs, including high molecular weight proteins, by several orders of magnitude, thus making transdermal administration of these molecules potentially feasible. It was possible to deliver and control therapeutic doses of proteins such as insulin, interferon gamma, and erythropoeitin across human skin. Low-frequency ultrasound is thus a potential noninvasive substitute for traditional methods of drug delivery, such as injections.read more
Citations
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Journal ArticleDOI
Designing hydrogels for controlled drug delivery.
Jianyu Li,David J. Mooney +1 more
TL;DR: This Review discusses how different mechanisms interact and can be integrated to exert fine control in time and space over the drug presentation, and collects experimental release data from the literature and presents quantitative comparisons between different systems to provide guidelines for the rational design of hydrogel delivery systems.
Journal ArticleDOI
Current status and future potential of transdermal drug delivery
TL;DR: The already significant impact this field has made on the administration of various pharmaceuticals is discussed; limitations of the current technology are explored; methods under exploration for overcoming these limitations and the challenges ahead are discussed.
Journal ArticleDOI
Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies
TL;DR: Recent advances in formulation and delivery strategies, such as the use of microsphere-based controlled-release technologies, protein modification methods that make use of polyethylene glycol and other polymers, and genetic manipulation of biopharmaceutical drugs are highlighted and discussed.
Journal ArticleDOI
Microfabricated microneedles: a novel approach to transdermal drug delivery.
TL;DR: These microneedle arrays could be easily inserted into skin without breaking and were shown to increase permeability of human skin in vitro to a model drug, calcein, by up to 4 orders of magnitude.
Journal ArticleDOI
Novel mechanisms and devices to enable successful transdermal drug delivery.
TL;DR: This review considers drug-vehicle interactions and the role of vesicles and particles and of particular interest is the synergy between chemical enhancers, ultrasound, iontophoresis and electroporation.
References
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Journal ArticleDOI
Electroporation of mammalian skin: a mechanism to enhance transdermal drug delivery
TL;DR: The measurements suggest that electroporation occurs in the intercellular lipid bilayers of the stratum corneum by a mechanism involving transient structural changes, which may have significance for drug delivery and other medical applications.
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Skin impedance from 1 Hz to 1 MHz
TL;DR: The impedance of skin coated with gel but otherwise unprepared was measured at ten sites on the thorax, leg, and forehead of ten subjects, which suggests that the variation in skin impedance can cause errors in two-electrode electrical impedance tomographs.
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A Mechanistic Study of Ultrasonically‐Enhanced Transdermal Drug Delivery
TL;DR: It is suggested that among all the ultrasound-related phenomena evaluated, cavitation plays the dominant role in sonophoresis using therapeutic ultrasound, and a theoretical model is developed to predict the effect of ultrasound on the transdermal transport of drugs.
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Amperometric glucose microelectrodes prepared through immobilization of glucose oxidase in redox hydrogels.
TL;DR: The results contrast with those observed for enzyme electrodes based on diffusing mediators, where loss of the enzyme-reduced mediator by radial diffusion to the solution decreases the current densities of microelectrode relative to similar macroelectrodes.