Uncatalysed reactions in water: Part 2. Preparation of 3-carboxycoumarins
TL;DR: In this article, a simple and environmentally friendly procedure has been developed for the reaction of Meldrum's acid with salicylaldehydes, and 3-Carboxycoumarins 5 were synthesised in high yields and excellent selectivities.
About: This article is published in Green Chemistry.The article was published on 2001-01-01. It has received 67 citations till now. The article focuses on the topics: Environmentally friendly.
Citations
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TL;DR: In this article, several Knoevenagel condensations of solid or liquid aromatic aldehydes are performed with four barbituric acids, Meldrum's acid, dimedone, cyanoacetamide, malodinitrile and methyl cyano-acetate.
273 citations
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TL;DR: In this paper, the state-of-the-art of renewable feedstock use in materials production using photopolymerization processes is discussed. And the main classes of naturally occurring molecules and macromolecules such as lipids, amino acids, carbohydrates, polyenes, etc.
199 citations
Cites background from "Uncatalysed reactions in water: Par..."
...These molecules are naturally present in many plants but have also been synthesized by different routes [196,197]....
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TL;DR: In this article, a 4-alkylcoumarin-3-carboxylic acid was obtained in high yields with excellent purity from ortho-hydroxybenzaldehydes and Meldrum's acid after a 2 h reflux in ethanol.
152 citations
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TL;DR: A novel and convenient silver-mediated radical cyclization method for the synthesis of coumarin derivatives via the direct difunctionalization of alkynoates with α-keto acids through double C-C bond formation under mild conditions has been developed.
Abstract: A novel and convenient silver-mediated radical cyclization method for the synthesis of coumarin derivatives via the direct difunctionalization of alkynoates with α-keto acids through double C–C bond formation under mild conditions has been developed. This new method is highly efficient and practical, and the starting materials are readily prepared. The present method should provide a useful strategy for the construction of coumarin motifs.
127 citations
References
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TL;DR: In this article, major advances have been made towards dcsign, realization, and optimization of efficient catalytic systems based on modified aluminosilicate mincrals, and a number of optimizations have been proposed.
Abstract: Major advances have been made towards dcsign, realization, and optimization of efficient catalytic systems based on modified aluminosilicate mincrals.
305 citations
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TL;DR: In this paper, the reaction of aldehydes, β-dicarbonyl compounds and urea (Biginelli reaction) has been performed over solid acid catalysis, under solventless conditions or in water affording dihydropyrimidines in good yield and selectivity.
281 citations
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TL;DR: In this paper, Collins argues that chemistry has an important role to play in developing the technological dimension of a sustainable civilization on Earth and the key to achieving this goal is a see change in chemical education and practice such that environmental considerations are comprehensively incorporated into chemical research and technology.
Abstract: The present economy relies on a massive inward flow of natural resources followed by a reverse flow of economically spent matter back to the ecosphere. In his essay,
Collins
argues that chemistry has an important role to play in developing the technological dimension of a sustainable civilization on Earth. The key to achieving this goal is a see change in chemical education and practice such that environmental considerations are comprehensively incorporated into chemical research and technology. First and foremost, persistent bioaccumulative pollutants must be eliminated in favor of more biocompatible substances and methods.
115 citations