Understanding and Preventing the Global Increase of Inflammatory Bowel Disease
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Cites background from "Understanding and Preventing the Gl..."
...Although IBD is a global disease with the highest prevalence in Western countries, newly industrialized countries in Asia, the Middle East, Africa, and South America have witnessed a rapid increase in its incidence [4]....
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487 citations
Cites background from "Understanding and Preventing the Gl..."
...In addition, industrialization led to marked increases in IBD prevalence rates in Asia (190)....
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References
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"Understanding and Preventing the Gl..." refers background in this paper
...Variation in the composition of the intestinal microbiota among individuals is greater in young children; infants have the highest susceptibility to microbial change in response to environmental factors.(93) Microbial exposures during early life affect development of the immune system and tolerance to environmental factors; this could contribute to risk of IBD in later life....
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"Understanding and Preventing the Gl..." refers background in this paper
...associated with Lactobacillus, Streptococcus, and Roseburia species.(98) These findings support the importance of interactions among environmental, dietary, microbial, and host factors....
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"Understanding and Preventing the Gl..." refers background in this paper
...The hygiene hypothesis, proposed by Strachan et al in the 19 century, provides an explanation for the rising incidence of autoimmune and allergic diseases in industrialized nations.(60) Factors inversely associated with risk of Crohn’s disease and ulcerative colitis include having pets in childhood, living on a farm, having a larger family, and drinking unpasteurized milk(61,62) The hygiene hypothesis, however, may not apply to all populations worldwide....
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