Understanding biophysicochemical interactions at the nano–bio interface
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...vessels, (3) glomeruloid microvascular proliferations (GMP), (4) vascular malformations, (5) 19 capillaries and (6) draining veins (FIG....
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...5% ID, respectively); (4) active-targeting strategies tend to outperform passive-targeting 17...
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...7 Researchers are starting to develop non-conventional strategies to improve DE, including: 8 (1) normalization of tumor vasculature; (2) use of bacteria and cells to deliver nanoparticles 9 to tumours; (3) engineering nanoparticles that can dynamically change size or create 10 different entry pathways into tumours to increase penetration depth; (4) manipulation of 11 the MPS system; and (5) surface coatings composed of cell-membrane components derived 12 from leukocytes or proteins such as CD47 that bind and inhibit phagocyte ingestion....
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...In a given medium, the most important nanoparticle characteristics that determine the surface properties are the material's chemical composition, surface functionalization, shape and angle of curvature, porosity and surface crystallinity, heterogeneity, roughness, and hydrophobicity or hydrophilicit...
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...Complement and immunoglobulin binding leads to particle opsonization: that is, it promotes receptor-mediated phagocytosi...
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