Journal ArticleDOI
Understanding the amyloid sensing mechanism of SYPRO Orange
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TLDR
In this paper, the photophysical properties of SYPRO Orange in different molecular solvents and solvent mixtures with wide range of properties were investigated to disentangle the fundamental processes that are responsible for its amyloid sensing activity.About:
This article is published in Dyes and Pigments.The article was published on 2021-10-01. It has received 2 citations till now. The article focuses on the topics: Amyloid.read more
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Sensing lysozyme fibrils by salicylaldimine substituted BODIPY dyes - A correlation with molecular structure.
TL;DR: In this article , a salicylaldimine Schiff base and its corresponding boron complex have been evaluated for their ability to sense amyloid fibrils from hen-egg white lysozyme using steady state and time-resolved spectroscopic techniques.
References
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Book
Principles of fluorescence spectroscopy
TL;DR: This book describes the fundamental aspects of fluorescence, the biochemical applications of this methodology, and the instrumentation used in fluorescence spectroscopy.
Journal ArticleDOI
Protein Misfolding, Functional Amyloid, and Human Disease
TL;DR: The relative importance of the common main-chain and side-chain interactions in determining the propensities of proteins to aggregate is discussed and some of the evidence that the oligomeric fibril precursors are the primary origins of pathological behavior is described.
Journal ArticleDOI
Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution.
TL;DR: Thioflavine T associates rapidly with aggregated fibrils of the synthetic β/A4‐derived peptides β( 1–28) and β(1–40), giving rise to a new excitation maximum at 450 nm and enhanced emission at 482 nm, as opposed to the 385 nm and 445 nm of the free dye.
Journal ArticleDOI
Molecular Volumes and the Stokes-Einstein Equation.
TL;DR: In this article, a simple notion of the volume of a molecule was adopted to produce an empirical correction factor for the Stokes equation to enable one to apply it to molecules down to two angstroms in radius.
Journal ArticleDOI
Alzheimer’s amyloid fibrils: structure and assembly
TL;DR: The amyloid-beta peptide has been examined in various solvents and conditions and this has led to a model by which a conformational switching occurs from alpha-helix or random coil, to a beta-sheet structure.
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