Upregulation of circulating IL-15 by treadmill running in healthy individuals: is IL-15 an endocrine mediator of the beneficial effects of endurance exercise?
Yoshiaki Tamura,Keiichi Watanabe,Tomomi Kantani,Junichi Hayashi,Nobuhiko Ishida,Masao Kaneki +5 more
Reads0
Chats0
TLDR
It is shown that in opposition to previous findings, 30-min treadmill running at 70% of age-predicted maximum heart rate resulted in a significant increase in circulating IL-15 level in untrained healthy young men, suggesting that IL- 15 might play a role in the systemic anti-obesogenic and insulin-sensitizing effects of endurance exercise.Abstract:
The beneficial effects of endurance exercise include insulin-sensitization and reduction of fat mass Limited knowledge is available about the mechanisms by which endurance exercise exerts the salutary effects Myokines, cytokines secreted by skeletal muscle, have been recognized as a potential mediator Recently, a role of skeletal muscle-derived interleukin-15 (IL-15) in improvement of fat-lean body mass composition and insulin sensitivity has been proposed Yet, previous studies have reported that endurance training does not increase production or secretion of IL-15 in skeletal muscle Here, we show that in opposition to previous findings, 30-min treadmill running at 70% of age-predicted maximum heart rate resulted in a significant increase in circulating IL-15 level in untrained healthy young men These findings suggest that IL-15 might play a role in the systemic anti-obesogenic and insulin-sensitizing effects of endurance exercise, not only as a paracrine and autocrine but also as an endocrine factorread more
Citations
More filters
Journal ArticleDOI
Adipo-Myokines: Two Sides of the Same Coin—Mediators of Inflammation and Mediators of Exercise
Silja Raschke,Jürgen Eckel +1 more
TL;DR: This review summarizes the current literature regarding the most discussed contraction-regulated moykines like IL-6, IL-15, irisin, BDNF, ANGPTL4, FGF21, myonectin and MCP-1 and tries to elaborate on the question why pro-inflammatory adipokines on the one hand are upregulated in the obese state, and have beneficial effects after exercise on the other hand.
Journal ArticleDOI
AMPK in skeletal muscle function and metabolism.
Rasmus Kjøbsted,Janne R. Hingst,Joachim Fentz,Marc Foretz,Marc Foretz,Marc Foretz,Maria Nieves Sanz,Christian Pehmøller,Michael Shum,André Marette,Rémi Mounier,Jonas T. Treebak,Jørgen F. P. Wojtaszewski,Benoit Viollet,Benoit Viollet,Benoit Viollet,Louise Lantier +16 more
TL;DR: The role of AMPK in skeletal muscle during exercise and in exercise recovery is focused on and adaptations to exercise training, including skeletal muscle plasticity, are addressed, highlighting novel concepts and future perspectives that need to be investigated.
Journal ArticleDOI
A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise
Wataru Aoi,Yuji Naito,Tomohisa Takagi,Yuko Tanimura,Y. Takanami,Yukari Kawai,Kunihiro Sakuma,Liu Po Hang,Katsura Mizushima,Yasuko Hirai,Ryota Koyama,Sayori Wada,Akane Higashi,Satoshi Kokura,Hiroshi Ichikawa,Toshikazu Yoshikawa +15 more
TL;DR: Findings suggest that exercise stimulates SPARC secretion from muscle tissues and that SPARC inhibits colon tumorigenesis by increasing apoptosis.
Journal ArticleDOI
Sarcopenia, obesity, and natural killer cell immune senescence in aging: altered cytokine levels as a common mechanism.
Charles T. Lutz,LeBris S. Quinn +1 more
TL;DR: It is posited that increased adipokine and decreased IL-15 levels during aging constitute a common mechanism for sarcopenia, obesity, and immune senescence.
Journal ArticleDOI
Role of Myokines in Regulating Skeletal Muscle Mass and Function.
Jong Han Lee,Hee-Sook Jun +1 more
TL;DR: This review article summarizes the current knowledge of major identified and characterized myokines focusing on their biological activity and function, particularly in muscle mass and function.
References
More filters
Journal ArticleDOI
The diseasome of physical inactivity - and the role of myokines in muscle-fat cross talk.
TL;DR: The finding that muscles produce and release myokines provides a conceptual basis to understand the mechanisms whereby exercise influences metabolism and exerts anti‐inflammatory effects.
Journal ArticleDOI
The role of the exercise test in the evaluation of patients for ischemic heart disease.
J F McNeer,James R. Margolis,Kerry L. Lee,Joseph Kisslo,Robert H. Peter,Yihong Kong,Victor S. Behar,Andrew G. Wallace,Charles B. McCants,R A Rosati +9 more
TL;DR: The exercise test is a nonin invasive, reproducible method to assess the presence and extent of anatomic disease and the prognosis when significant disease has been defined and should be used in conjunction with other noninvasive tests to determine optimal management in patients evaluated for ischemic heart disease.
Journal ArticleDOI
A trauma-like elevation of plasma cytokines in humans in response to treadmill running.
Kenneth Ostrowski,Claus Hermann,Aimal Bangash,Peter Schjerling,Jakob Nielsen,Bente Klarlund Pedersen +5 more
TL;DR: The results suggest that very early events in exercise trigger the release of IL‐6, and that the cytokine response to exercise has similarities to that observed after trauma.
Journal ArticleDOI
Carbohydrate ingestion influences skeletal muscle cytokine mRNA and plasma cytokine levels after a 3-h run.
David C. Nieman,J. M. Davis,Dru A. Henson,J. Walberg-Rankin,M. Shute,Charles L. Dumke,Alan C. Utter,Debra M. Vinci,James A. Carson,Adrienne S. Brown,W J. Lee,Steven R. McAnulty,Lisa S. McAnulty +12 more
TL;DR: Sixteen experienced marathoners ran on treadmills for 3 h at ∼70% maximal oxygen consumption (V˙o 2 max) on two occasions while receiving 1 l/h carbohydrate (CHO) or placebo (Pla) beverages.
Journal ArticleDOI
Interleukin-6 Depletion Selectively Improves Hepatic Insulin Action in Obesity
TL;DR: Results indicate that IL-6 plays an important and selective role in hepatic insulin resistance of obesity, and depletion of IL- 6 improved insulin responsiveness in 2-h insulin tolerance tests.