Open AccessJournal Article
Urinary bladder carcinogenicity of N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide in female Swiss mice.
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N -[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide was fed to 50 female 5-week-old Swiss mice at a dose of 0.094% by weight of diet for 46 weeks, followed by 7 weeks of the control diet.Abstract:
N -[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide was fed to 50 female 5-week-old Swiss mice at a dose of 0.094% by weight of diet for 46 weeks, followed by 7 weeks of the control diet. Fifty-six mice received only the control diet. Thirty-three test mice survived 40 weeks or longer and had the following tumor incidences: urinary bladder, 31/33; generalized leukemia, 23/33; lung, 6/33; and 1 uterine tumor. In the controls, the following tumor incidences were found: generalized leukemia, 15/44; and lung, 1/44.read more
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References
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Journal Article
The production of carcinoma of the urinary bladder in rats by feeding N-[3-(5-nitro-2-furyl)-2-thiazolyl]formamide.
TL;DR: The first nitrofuran derivative which has been found to be a bladder carcinogen, and the compound appears to be one of the most effective bladder carcinogens for this species.
Journal Article
Pathogenesis, Histology, and Transplantability of Urinary Bladder Carcinomas Induced in Albino Rats by Oral Administration of N-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide
TL;DR: N-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide appears to be one of the most effective urinary bladder carcinogens for both male and female Sprague-Dawley rats, providing carcinomas exhibiting all criteria of malignancy.
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The histological changes in the mouse bladder following surgical implantation of paraffin wax pellets containing various chemicals
Georgiana M. Bonser,J. W. Jull +1 more
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Correlation between the chemical induction of hyperplasia and of malignancy in the bladder epithelium.
TL;DR: Correlation Between the Chemical Induction of Hyperplasia and of Malignancy in the Bladder Epithelium is found to be significant and consistent with prior studies of this type of association.
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The induction of tumours of the mouse bladder epithelium by 4-ethylsulphonylnaphthalene-1-sulphonamide.
D B Clayson,G M Bonser +1 more
TL;DR: The Induction of Tumours of the Mouse Bladder Epithelium by 4-Ethylsulphonylnaphthalene-1-Sulphonamide is studied.