Urine Proteome of COVID-19 Patients
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280 citations
Cites result from "Urine Proteome of COVID-19 Patients..."
...These reports, in combination with results from both targeted and unbiased proteomic studies, have increased the likelihood that complement activation is a key contributor to the COVID-19 pathogenesis (12-17)....
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...These data, along with human proteomic studies (15, 16), suggest that coronavirus infections involve the activation of multiple complement pathways....
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References
22,622 citations
"Urine Proteome of COVID-19 Patients..." refers background in this paper
...https://doi.org/10.1101/2020.05.02.20088666 doi: medRxiv preprint and its host response, epidemiological and clinical characteristics to mitigate the current pandemic [1, [3] [4] [5] [6] [7] [8] [9] [10] ....
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...The SARS-CoV-2 has been reported to be harmful to lung, liver, heart, testis, bladder and kidney, where ACE2 are highly expressed [5, 8, 9, 12, 13] ....
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...Although much effort towards COVID-19 diagnostics and treatment has been made, the mortality of this infectious disease has not been significantly improved because of the limited mechanistic understanding of the pathogenesis [2, 32] . Patients progress into the S-COVID often face very limited treatment options [8, 9] ....
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21,455 citations
16,857 citations
"Urine Proteome of COVID-19 Patients..." refers background in this paper
...Coronavirus Disease-2019 (COVID-19) is caused by a novel virus strain, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is an unprecedented global health threat [1, 2]....
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16,635 citations
Additional excerpts
...Compared to the SARS-CoV spike (S) protein, the homologous SARS-CoV-2 S protein showed a higher affinity interaction with angiotensin-converting enzyme 2 (ACE2), which is thought to be the major receptor mediating the entry of the virus into the cell [11]....
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16,282 citations