Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials

doi:10.1002/HEP.26455

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Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials

Journal Article•DOI•

Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials

Mazen Noureddin¹, Jessica Lam, Michael R. Peterson, Michael S. Middleton, Gavin Hamilton, Thuy-Anh Le², Ricki Bettencourt², Christopher Changchien, David A. Brenner², Claude B. Sirlin, Rohit Loomba² - Show less +7 more•Institutions (2)

University of California, San Diego¹, University of California, Berkeley²

01 Dec 2013-Hepatology (NIH Public Access)-Vol. 58, Iss: 6, pp 1930-1940

TL;DR: MRI‐ PDFF correlated well with MRS‐PDFF and was more sensitive than the histology‐determined steatosis grade in quantifying increases or decreases in the liver fat content, and could be used to quantify changes in liver fat in future clinical trials.

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About: This article is published in Hepatology.The article was published on 2013-12-01 and is currently open access. It has received 419 citations till now. The article focuses on the topics: Fatty liver & Nonalcoholic fatty liver disease.

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Journal Article•DOI•

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases.

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Naga Chalasani¹, Zobair M. Younossi², Joel E. Lavine³, Michael Charlton⁴, Kenneth Cusi⁵, Mary E. Rinella⁶, Stephen A. Harrison⁷, Elizabeth M. Brunt⁸, Arun J. Sanyal⁹ - Show less +5 more•Institutions (9)

Indiana University¹, Inova Fairfax Hospital², Columbia University³, University of Chicago⁴, University of Florida⁵, Northwestern University⁶, Pinnacle Financial Partners⁷, Washington University in St. Louis⁸, Virginia Commonwealth University⁹

01 Jan 2018-Hepatology

TL;DR: This guidance provides a data-supported approach to the diagnostic, therapeutic, and preventive aspects of NAFLD care.

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4,431 citations

Cites methods from "Utility of magnetic resonance imagi..."

...MR imaging, either by spectroscopy((92)) or by proton density fat fraction,((93,94)) is an excellent noninvasive modality for quantifying HS and is being widely used in NAFLD clinical trials.((95)) The use of TE to obtain continuous attenuation parameters is a promising tool for quantifying hepatic fat in an ambulatory setting....
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Journal Article•DOI•

Noninvasive Assessment of Liver Disease in Patients With Nonalcoholic Fatty Liver Disease.

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Laurent Castera¹, Mireen Friedrich-Rust², Rohit Loomba³•Institutions (3)

French Institute of Health and Medical Research¹, Goethe University Frankfurt², University of California, San Diego³

01 Apr 2019-Gastroenterology

TL;DR: The current state of the noninvasive assessment of liver disease in NAFLD is summarized, and an expert synthesis of how these nonin invasive tools could be utilized in clinical practice is provided.

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780 citations

Journal Article•DOI•

Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients with Biopsy-proven Nonalcoholic Fatty Liver Disease

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Charlie C. Park¹, Phirum Nguyen¹, Carolyn Hernandez¹, Ricki Bettencourt¹, Kimberly Ramirez¹, Lynda Fortney¹, Jonathan Hooker¹, Ethan Z. Sy¹, Michael T. Savides¹, Mosab H. Alquiraish¹, Mark A. Valasek¹, Emily Rizo¹, Lisa Richards¹, David A. Brenner¹, Claude B. Sirlin¹, Rohit Loomba¹ - Show less +12 more•Institutions (1)

University of California, San Diego¹

01 Feb 2017-Gastroenterology

TL;DR: In a prospective, cross-sectional study of more than 100 patients, MRE is found to be more accurate than TE in identification of liver fibrosis (stage 1 or more), using biopsy analysis as the standard and MRI-PDFF is more accurate in detecting all grades of steatosis in patients with NAFLD.

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441 citations

Cites background from "Utility of magnetic resonance imagi..."

...Other advantages of MRI-based techniques over TE include larger area of the liver measured, which may reduce sampling variability secondary to heterogeneity of fibrosis,(9,11) and the utility of MRI-PDFF for assessing longitudinal changes in steatosis.(47) Although TE has excellent inter- and intraoperator reproducibility(48) and is accurate for diagnosing cirrhosis,(12) its applicability is limited by high failure rates in patients with narrow intercostal space and ascites,(12) interference of liver stiffness measurements by extrahepatic cholestasis and acute liver injury,(49,50) and reduced reproducibility in early stages of fibrosis and in the presence of steatosis....
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Journal Article•DOI•

Clinical epidemiology and disease burden of nonalcoholic fatty liver disease

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Brandon J Perumpail¹, Muhammad Ali Khan², Eric R. Yoo³, George Cholankeril⁴, Donghee Kim⁴, Aijaz Ahmed⁴ - Show less +2 more•Institutions (4)

Drexel University¹, University of Tennessee Health Science Center², Santa Clara Valley Medical Center³, Stanford University⁴

21 Dec 2017-World Journal of Gastroenterology

TL;DR: The increasing prevalence of NAFLD with advanced fibrosis, is concerning because patients appear to experience higher liver-related and non-liver-related mortality than the general population, and one that requires more in-depth analysis.

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Abstract: Nonalcoholic fatty liver disease (NAFLD) is defined as the presence of hepatic fat accumulation after the exclusion of other causes of hepatic steatosis, including other causes of liver disease, excessive alcohol consumption, and other conditions that may lead to hepatic steatosis. NAFLD encompasses a broad clinical spectrum ranging from nonalcoholic fatty liver to nonalcoholic steatohepatitis (NASH), advanced fibrosis, cirrhosis, and finally hepatocellular carcinoma (HCC). NAFLD is the most common liver disease in the world and NASH may soon become the most common indication for liver transplantation. Ongoing persistence of obesity with increasing rate of diabetes will increase the prevalence of NAFLD, and as this population ages, many will develop cirrhosis and end-stage liver disease. There has been a general increase in the prevalence of NAFLD, with Asia leading the rise, yet the United States is following closely behind with a rising prevalence from 15% in 2005 to 25% within 5 years. NAFLD is commonly associated with metabolic comorbidities, including obesity, type II diabetes, dyslipidemia, and metabolic syndrome. Our understanding of the pathophysiology of NAFLD is constantly evolving. Based on NAFLD subtypes, it has the potential to progress into advanced fibrosis, end-stage liver disease and HCC. The increasing prevalence of NAFLD with advanced fibrosis, is concerning because patients appear to experience higher liver-related and non-liver-related mortality than the general population. The increased morbidity and mortality, healthcare costs and declining health related quality of life associated with NAFLD makes it a formidable disease, and one that requires more in-depth analysis.

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440 citations

Journal Article•DOI•

The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial

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Rohit Loomba¹, Eric Lawitz, Parvez S. Mantry, Saumya Jayakumar, Stephen H. Caldwell, Hays Arnold, Anna Mae Diehl², C. Stephen Djedjos, Ling Han, Robert P. Myers, G. Mani Subramanian, John G. McHutchison, Zachary Goodman, Nezam H. Afdhal, Michael Charlton - Show less +11 more•Institutions (2)

University of California, Berkeley¹, Duke University²

01 Feb 2018-Hepatology

TL;DR: Selonsertib may reduce liver fibrosis in patients with nonalcoholic steatohepatitis and stage 2‐3 fibrosis and there were no significant differences in adverse events between the treatment groups.

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437 citations

Cites methods from "Utility of magnetic resonance imagi..."

...Estimations of liver stiffness by magnetic resonance elastography (MRE) and of the quantity of hepatic fat by magnetic resonance imagingestimated proton density fat fraction (MRI-PDFF) have shown strong correlations with histology and low interobserver variability, suggesting that these noninvasive methods may be reliable, accurate, and precise tools for clinical assessment of the extent of liver fibrosis.((29-34)) We conducted a phase 2, randomized, open-label study to assess the safety and efficacy of selonsertib with and without simtuzumab or simtuzumab alone in patients with moderate to severe fibrosis resulting from NASH....
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...The methodology and assessments of changes in these parameters in colocalized regions of interest were performed as described.((29-34,37,38)) All sites underwent a qualityassessment process prior to study initiation, and all images were approved by the central reader....
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...Metabolic factors Body mass index, kg/m(2) 33 (30-37) 33 (29-41) 37 (31-37)...
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Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption-II

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Abstract: The Alcohol Use Disorders Identification Test (AUDIT) has been developed from a six-country WHO collaborative project as a screening instrument for hazardous and harmful alcohol consumption. It is a 10-item questionnaire which covers the domains of alcohol consumption, drinking behaviour, and alcohol-related problems. Questions were selected from a 150-item assessment schedule (which was administered to 1888 persons attending representative primary health care facilities) on the basis of their representativeness for these conceptual domains and their perceived usefulness for intervention. Responses to each question are scored from 0 to 4, giving a maximum possible score of 40. Among those diagnosed as having hazardous or harmful alcohol use, 92% had an AUDIT score of 8 or more, and 94% of those with non-hazardous consumption had a score of less than 8. AUDIT provides a simple method of early detection of hazardous and harmful alcohol use in primary health care settings and is the first instrument of its type to be derived on the basis of a cross-national study.

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Journal Article•DOI•

Design and validation of a histological scoring system for nonalcoholic fatty liver disease

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David E. Kleiner¹, Elizabeth M. Brunt², Mark L. Van Natta³, Cynthia Behling⁴, Melissa J. Contos⁵, Oscar W. Cummings, Linda D. Ferrell⁶, Yao Chang Liu⁷, Michael Torbenson³, Aynur Unalp-Arida³, Matthew M. Yeh⁸, Arthur J. McCullough⁷, Arun J. Sanyal⁹ - Show less +9 more•Institutions (9)

National Institutes of Health¹, Saint Louis University², Johns Hopkins University³, University of California, San Diego⁴, Virginia Commonwealth University⁵, University of California, San Francisco⁶, MetroHealth⁷, University of Washington Medical Center⁸, VCU Medical Center⁹

01 Jun 2005-Hepatology

TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.

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Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity

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Jeffrey D. Browning, Lidia S. Szczepaniak¹, Robert L. Dobbins, Pamela Nuremberg², Jay D. Horton, Jonathan Cohen, Scott M. Grundy³, Helen H. Hobbs⁴ - Show less +4 more•Institutions (4)

University of Texas Southwestern Medical Center¹, Texas Scottish Rite Hospital for Children², Veterans Health Administration³, Howard Hughes Medical Institute⁴

01 Dec 2004-Hepatology

TL;DR: The prevalence of hepatic steatosis was greater in men than women among whites, but not in blacks or Hispanics, and significant ethnic and sex differences in the prevalence may have a profound impact on susceptibility to Steatosis‐related liver disease.

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3,429 citations

Journal Article•DOI•

The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

[...]

Naga Chalasani¹, Zobair M. Younossi², Joel E. Lavine³, Anna Mae Diehl⁴, Elizabeth M. Brunt⁵, Kenneth Cusi⁶, Michael Charlton⁷, Arun J. Sanyal⁸ - Show less +4 more•Institutions (8)

Indiana University¹, Inova Fairfax Hospital², Columbia University³, Duke University⁴, Washington University in St. Louis⁵, University of Florida⁶, Mayo Clinic⁷, Virginia Commonwealth University⁸

01 Jun 2012-Hepatology

TL;DR: This is a practice guideline for clinicians rather than a review article and interested readers can refer to several comprehensive reviews published recently.

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3,212 citations