Utilizing Buprenorphine in the Emergency Department after Overdose
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TLDR
The United States is currently in the midst of an opioid epidemic and barriers to treatment in the emergency department can lead to missed opportunities for helping prevent overdose and relapse in individuals with opioid use disorder.About:
This article is published in Trends in Pharmacological Sciences.The article was published on 2018-12-01 and is currently open access. It has received 10 citations till now. The article focuses on the topics: Buprenorphine & Opioid use disorder.read more
Citations
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Journal ArticleDOI
Progress in agonist therapy for substance use disorders: Lessons learned from methadone and buprenorphine.
TL;DR: It is argued that future studies should identify agonist pharmacotherapies that can facilitate abstinence in patients who are motivated to quit their illicit drug use and focus on those that are able to achieve abstinence from cocaine to broaden the effectiveness of medication and psychosocial treatment strategies for this underserved population.
Journal ArticleDOI
Replication of an emergency department-based recovery coaching intervention and pilot testing of pragmatic trial protocols within the context of Indiana's Opioid State Targeted Response plan.
Dennis P. Watson,Krista Brucker,Alan B. McGuire,Nyssa L. Snow-Hill,Huiping Xu,Alex Cohen,Mark Campbell,Lisa S. Robison,Emily Sightes,Rebecca Buhner,Daniel O'Donnell,Jeffrey A. Kline +11 more
TL;DR: A pilot study of Project Planned Outreach, Intervention, Naloxone, and Treatment (POINT), the intervention that served as the basis for Indiana's STR-funded, emergency department (ED)-based peer specialist expansion that was conducted in preparation for a larger, multisite pragmatic trial.
Posted ContentDOI
Rise and Regional Disparities in Buprenorphine Utilization in the United States
Amir Azar R. Pashmineh,Alexandra Cruz-Mullane,Jaclyn C. Podd,Warren S. Lam,Suhail H. Kaleem,Laura B. Lockard,Mark Mandel,Daniel Y. Chung,Corey S. Davis,Stephanie D. Nichols,Stephanie D. Nichols,Kenneth L. McCall,Brian J. Piper +12 more
TL;DR: Although buprenorphine availability has substantially increased over the last decade, distribution was very non-homogenous across the US.
Journal ArticleDOI
Emergency Department-initiated Interventions for Patients With Opioid Use Disorder: A Systematic Review.
TL;DR: A systematic review of the literature on interventions targeting OUDs initiated in EDs finds that emergency departments represent a potentially strategic setting for interventions to reduce harm from opioid use disorder.
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Evaluation of an emergency department-based opioid overdose survivor intervention: Difference-in-difference analysis of electronic health record data to assess key outcomes.
Dennis P. Watson,T. S. Weathers,Alan B. McGuire,Alex Cohen,Philip Huynh,Clay Bowes,Daniel O'Donnell,Krista Brucker,Sumedha Gupta +8 more
TL;DR: The Project POINT as discussed by the authors is an ED-based intervention aimed at providing opioid overdose survivors with naloxone and recovery supports and connecting them to evidence-based medications for opioid use disorder (MOUD).
References
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Emergency Department–Initiated Buprenorphine/Naloxone Treatment for Opioid Dependence: A Randomized Clinical Trial
Gail D'Onofrio,Patrick G. O'Connor,Michael V. Pantalon,Marek C. Chawarski,Susan H. Busch,Patricia H. Owens,Steven L. Bernstein,David A. Fiellin +7 more
TL;DR: Among opioid-dependent patients, ED-initiated buprenorphine treatment vs brief intervention and referral significantly increased engagement in addiction treatment, reduced self-reported illicit opioid use, and decreased use of inpatient addiction treatment services but did not significantly decrease the rates of urine samples that tested positive for opioids or of HIV risk.
Journal Article
Acute administration of buprenorphine in humans: Partial agonist and blockade effects
TL;DR: There is a ceiling on the effects of buprenorphine in humans that may reduce its abuse liability and increase its safety, and indicate that opioid blockade occurs after acute administration of bu p.o.m. or methadone.
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A review of buprenorphine diversion and misuse: the current evidence base and experiences from around the world.
TL;DR: The objective was to facilitate understanding of diversion and misuse so that all factors influencing their expression can be appreciated within a framework that also recognizes the benefits of addiction treatment.
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Therapeutic alliance and psychiatric severity as predictors of completion of treatment for opioid dependence.
Nancy M. Petry,Warren K. Bickel +1 more
TL;DR: The results underscore the importance of early identification of opioid-dependent patients with moderate to severe levels of psychopathology and suggest a strong therapeutic alliance may be an essential condition for successful treatment.
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Identification, Management, and Transition of Care for Patients With Opioid Use Disorder in the Emergency Department.
Herbert C. Duber,Isabel A. Barata,Eric Cioè-Peña,Stephen Y. Liang,Eric M Ketcham,Wendy Macias-Konstantopoulos,Shawn A. Ryan,Mark Stavros,Lauren K. Whiteside +8 more
TL;DR: This clinical review article examines current strategies for identifying patients with opioid use disorder, the treatment of patients with acute opioid withdrawal syndrome, approaches to medication‐assisted therapy, and the transition of patients from the emergency department to outpatient services.