Journal ArticleDOI
Uvangoletin, extracted from Sarcandra glabra, exerts anticancer activity by inducing autophagy and apoptosis and inhibiting invasion and migration on hepatocellular carcinoma cells.
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In this paper, the effects of uvangoletin on hepatocellular carcinoma (HCC) were investigated using MTT and hepG2 xenograft model.About:
This article is published in Phytomedicine.The article was published on 2022-01-01. It has received 5 citations till now. The article focuses on the topics: Autophagy & Apoptosis.read more
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Natural-Product-Mediated Autophagy in the Treatment of Various Liver Diseases
TL;DR: In this article , a review of autophagy-regulative natural product-based drugs for the treatment of liver diseases is presented, and a novel scoring system is established to critically evaluate the completeness and scientific significance of the reviewed literature.
Journal ArticleDOI
Dihydrochalcones as antitumor agents.
TL;DR: In this article , the authors present a review of the pharmacological properties of dihydrochalcones with a particular attention to their antitumor activity against a panel of cancer cell lines and to the description of the inhibition mechanisms of cell proliferation.
Journal ArticleDOI
Necroptosis inhibits autophagy by regulating the formation of RIP3/p62/Keap1 complex in shikonin-induced ROS dependent cell death of human bladder cancer.
Xiao-Jie Liu,Lu Liu,Xu Wang,Yu Jin,Shuang Wang,Qinge Xie,Meng-wen Zhang,Jinfen Liu,Zhen-yuan Wang,Cheng-Yun Jin +9 more
TL;DR: Wang et al. as discussed by the authors investigated the role of shikonin in bladder cancer in vitro and in vivo in order to broaden the scope of SHIKONIN's clinical application.
Journal ArticleDOI
Molecular Mechanism of Naringenin Against High-Glucose-Induced Vascular Smooth Muscle Cells Proliferation and Migration Based on Network Pharmacology and Transcriptomic Analyses
TL;DR: In this paper , the potential targets and molecular mechanism of Nar when used to treat high-glucose-induced vasculopathy based on transcriptomics, network pharmacology, molecular docking, and in vivo and in vitro assays were clarified.
Journal ArticleDOI
Utilization of methanol for condensation interrupted chemoselective transfer hydrogenation of C=C, C=O, and C=N bonds under low catalyst loading
TL;DR: In this paper , selective transfer hydrogenation (TH) of unsaturated molecules using methanol is challenging as the in situ generated formaldehyde is prone to react with the active methylene (C-methylation) or amine (N)-methylation core.
References
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The basics of epithelial-mesenchymal transition
Raghu Kalluri,Robert A. Weinberg +1 more
TL;DR: Processes similar to the EMTs associated with embryo implantation, embryogenesis, and organ development are appropriated and subverted by chronically inflamed tissues and neoplasias and the identification of the signaling pathways that lead to activation of EMT programs during these disease processes is providing new insights into the plasticity of cellular phenotypes.
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Molecular mechanisms of epithelial–mesenchymal transition
TL;DR: The reprogramming of gene expression during EMT, as well as non-transcriptional changes, are initiated and controlled by signalling pathways that respond to extracellular cues, and the convergence of signalling pathways is essential for EMT.
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Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
TL;DR: In addition to their role in extracellular matrix turnover and cancer cell migration, MMPs regulate signaling pathways that control cell growth, inflammation, or angiogenesis and may even work in a nonproteolytic manner.
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Signal integration by JNK and p38 MAPK pathways in cancer development
Erwin F. Wagner,Angel R. Nebreda +1 more
TL;DR: This Review highlights the recent progress made in defining the functions of the JNK and p38 MAPK pathways in different cancers.
Journal ArticleDOI
Autophagy in human health and disease.
TL;DR: This review discusses the cellular process of autophagy (“self-eating”), which plays key roles in normal development of the immune system and adaptation to stress, as well as in a wide range of disease states.