Journal ArticleDOI
VEGF aptamer/i-motif-grafted multi-functional SPION nanocarrier for chemotherapeutic/phototherapeutic synergistic research.
Bo Fu,Hui-Chao Lin,Ying-Chun Liu,Jie-Rou Lin,Wen-Ming Xiong,Shu-Jun Deng,Nian Chen,Rui Liang,Ping Zhao +8 more
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TLDR
In this paper, various drug delivery systems (DDS) have been used to address the problems of poor tumor selectivity, high side toxicity, or low water solubility.Abstract:
Chemotherapeutic agents and photosensitizers often suffer from poor tumor selectivity, high side toxicity, or low water solubility. To address these problems, various drug delivery systems (DDS) ha...read more
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DNA-Based Nanomaterials as Drug Delivery Platforms for Increasing the Effect of Drugs in Tumors
A. N. Shishparenok,D. D. Zhdanov +1 more
TL;DR: In this paper , a review of DNA-based nanomaterials, such as tetrahedrons, origami, DNA nanotubes, and aptamers, that have been used as carriers, drugs or target molecules for anticancer drug delivery is presented.
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ROS signalling in the biology of cancer.
TL;DR: The generation and sources of ROS within tumour cells, the regulation of ROS by antioxidant defence systems, as well as the effect of elevated ROS production on their signalling targets in cancer are discussed.
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ROS in Cancer: The Burning Question
TL;DR: This work posits that ROS do not operate as one single biochemical entity, but as diverse secondary messengers in cancer cells, and cautions against therapeutic strategies to increase ROS at a global level.
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Understanding Apoptosis and Apoptotic Pathways Targeted Cancer Therapeutics.
Rehmat Jan,Gul-e-Saba Chaudhry +1 more
TL;DR: This review focused on the underlying mechanism of apoptosis and the dysregulation of apoptotic modulators involved in the extrinsic and intrinsic apoptotic pathway, which include death receptors (DRs) proteins, cellular FLICE inhibitory proteins (c-FLIP), anti-apoptotic Bcl-2 proteins, inhibitors of apoptOS proteins (IAPs), tumor suppressor (p53) in cancer cells along with various current clinical approaches aimed to selectively induce apoptosis.
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Mitochondria, Bioenergetics and Apoptosis in Cancer
TL;DR: New evidence points to a more intimate link between these two functions, mediated by the remodeling of the mitochondrial ultrastructure during apoptosis, which may lead to new avenues for therapy.
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Recent advances of multi-dimensional porphyrin-based functional materials in photodynamic therapy
TL;DR: Porphyrin-based functional materials provide more fascinating superiorities in photodynamic therapy and dramatically expand the potentials and possibilities in cancer treatments as discussed by the authors, however, the poor water-solubility, low biostability and non-specific tumor-targeting properties of porphyrins limit the photodynamic treatment efficiency and their clinical applications.