scispace - formally typeset
Search or ask a question
Book ChapterDOI

Verruga peruviana oder Carrionsche Krankheit

01 Jan 1932-pp 215-242
TL;DR: Verruga peruviana wird eine seit der Eroberung der Westkuste Sudamerikas durch dir Spainer bekannte, nur in den hochgelegenen talern der peruanischen Anden vorkommende, eigenartiage, knotige Hautefflorescenz genannten bezeichnet, die im Zusammenhang mit einer ihr vorausgehenden, Oroyafieber genanNTen Allgemeinerkr
Abstract: Als „Verruga peruviana“ wird eine seit der Eroberung der Westkuste Sudamerikas durch dir Spainer bekannte, nur in den hochgelegenen talern der peruanischen Anden vorkommende, eigenartiage, knotige Hautefflorescenz genannten bezeichnet, die im Zusammenhang mit einer ihr vorausgehenden, Oroyafieber genannten Allgemeinerkrankung in Erscheinung tritt.
Citations
More filters
Book ChapterDOI
01 Jan 1932
TL;DR: In this article, a Gruppe von Mikroorganismen, deren Parasitennatur erst in den letzten Jahren sichergestellt werden konnte, is described.
Abstract: Unter Bartonellen versteht man eine Gruppe von Mikroorganismen, deren Parasitennatur erst in den letzten Jahren sichergestellt werden konnte, deren Einordnung in ein System der Mikroorganismen aber weiteren Forschungen uberlassen werden mus. Obgleich sie morphologisch eine grose Ahnlichkeit mit den Bakterien besitzen, mussen sie doch aus vielerlei Grunden als eine gesonderte Parasitengruppe behandelt werden. Beim Oroyafieber des Menschen, einer in Peru vorkommenden bosartigen Erkrankung, sind sie als in den Erythrocyten gelegene Einschlusse schon langere Zeit bekannt. Im Tierreich scheinen sie als Krankheitserreger und anscheinend harmlose Blutschmarotzer verbreiteter zu sein, als man bisher annahm.

4 citations

Book ChapterDOI
01 Jan 1952
TL;DR: Mikroorganismen werden Mikro Organismen bezeichnet, die als Parasiten der roten Blutkorperchen auftreten, die bei Tieren in der ganzen Welt weit verbreiteten latenten Infektionen fuhren meist erst nach Entfernung der Milz zu einer Erkrankung.
Abstract: Als Bartonellen (Strong, Tyzzer und Sellards 1915, emend. Tyzzer und Weinman 1939) werden Mikroorganismen bezeichnet, die als Parasiten der roten Blutkorperchen auftreten. Sie erscheinen in gefarbten Blutausstrichen als rundliche oder stabchenformige Gebilde ohne Anzeichen einer Innenstruktur oder einer Differenzierung in Cytoplasma und Kern. Beim Menschen sind sie als Bartonella bacilliformis die Erreger einer nur in bestimmten Gebieten Sudamerikas, vielleicht auch in Mittelamerika heimischen, mit Fieber einhergehenden infektiosen Anamie von perniziosem Typ (Oroyafieber) bekannt, der haufig eine eigenartige Hauteruption (Verruga peruana) folgt. Verwandte, im Genus Haemobartonella zusammengefaste Parasiten werden als Anamieerreger bei verschiedenen Tieren gefunden (H. muris Mayer 1921, H. canis Kikuth 1929, H. bovis Donatien und Lestoquard 1934 u. a.). Sie unterscheiden sich von der B. bacilliformis dadurch, das bei ihnen eine Vermehrung auserhalb des Blutes in Gewebszellen nicht nachweisbar ist und das sie keine Hautlasionen verursachen. Die bei Tieren in der ganzen Welt weit verbreiteten latenten Infektionen fuhren meist erst nach Entfernung der Milz zu einer Erkrankung.

2 citations

Book ChapterDOI
01 Jan 1961
TL;DR: In this paper, ausfuhrliche Abhandlung aus der Feder eines hervorragenden Kenners der Bartonellen-Infektionen vor: „Verruga peruviana oder Carrionsche Krankheit (Oroya-Fieber)“ von H. darocha-lima im Band XII, Teil 1, S. 215-242 (1932).
Abstract: Die Besprechung der Bartonellosen kann hier aus mehreren Grunden kurz erfolgen. Erstens liegt im alten Jadassohnschen Handbuch eine ausfuhrliche Abhandlung aus der Feder eines hervorragenden Kenners der Bartonellen-Infektionen vor: „Verruga peruviana oder Carrionsche Krankheit (Oroya-Fieber)“ von H. darocha-lima im Band XII, Teil 1, S. 215-242 (1932). Aus diesem Beitrag sind die noch heute gultigen Daten uber die Geschichte, Epidemiologie, Pathologie, Atiologie, Diagnose, Klinik und Differentialdiagnose der Krankheit ersichtlich. Zweitens wird die Carrionsche Krankheit, die in den Hochtalern der Anden endemisch ist, immer seltener und stirbt moglicherweise ganz aus. Der dritte Grund aber ist der wichtigste ! Aus den neueren experimentellen Untersuchungen (s. bei Wigand 1958) geht zweifelsfrei hervor, das der Erreger der menschlichen Bartonellosis nicht zu den grosen Viren, Grahamellen und Rickettsien gehort, sondern ein Bacterium darstellt (Einzelheiten weiter unten!). Verruga peruviana und Oroyafieber sollten daher kunftig bei den bakteriellen Infektionen erortert werden. Wir entschlossen uns nur deshalb dazu, sie hier in Kurze abzuhandeln, weil die Tierbartonellen im Reich der Mikroorganismen eine Sonderstellung einnehmen und zwischen den Bakterien einerseits und den grosen Viren andererseits eingereiht werden mussen. Menschliche und tierische Bartonellen sind Blutparasiten. Auser diesem gemeinsamen Merkmal besitzen sie jedoch kaum weitere ubereinstimmende Eigenschaften.
References
More filters
Journal ArticleDOI
TL;DR: The organism can be cultivated from the blood over a long period, and it has been detected within the red corpuscles of the monkeys, reproducing the precise appearances observed in human cases of Oroya fever.
Abstract: A pure culture of a microorganism resembling in morphology and pathogenic action Bartonella bacilliformis has been obtained from blood taken during life from a case of Oroya fever which ended fatally The blood taken at Lima into citrate solution and transported to New York at refrigerator temperature yielded positive cultures 28 days after its withdrawal from the patient The strain of Bartonella bacilliformis thus isolated grows well on the semisolid leptospira medium, and also on slant agar containing animal blood The initial growth is not readily recognizable to the naked eye, but the presence of the organisms can be determined by means of the dark-field microscope and by Giemsa and Gram staining methods No growth has been obtained on the more ordinary culture media The organism is an obligate aerobe, is Gram-negative, and under certain cultural conditions motile All the forms which have been described as occurring in human red corpuscles may be found in the cultures, and in addition many granular and coarsely irregular forms have been met with The inoculation of cultures of Bartonella bacilliformis into Macacus rhesus produces infection and gives rise to effects which differ with the mode of inoculation The intravenous injection of the culture into young macaques induces a prolonged irregularly remittent fever The organism can be cultivated from the blood over a long period, and it has been detected within the red corpuscles of the monkeys, reproducing the precise appearances observed in human cases of Oroya fever The intradermal injection of the culture into the eyebrow of young macaques gives rise to nodular formations rich in new blood vessels and showing the bacilliform organism within the endothelial cells From the experimentally induced nodules cultures of the organism are readily recovered

50 citations

Journal ArticleDOI
TL;DR: The symptoms and lesions observed in the chimpanzee and ourangutan as a result of infection with Bartonella bacilliformis are far milder than those of rhesus monkeys and show less resemblance to human Oroya fever or verruga.
Abstract: The inoculation of a chimpanzee with cultures and a passage strain of Bartonella bacilliformis induced local reactions which, while definite and characteristic, progressed less rapidly and were much less striking than those in the control rhesus monkey. Bartonella bacilliformis was demonstrated in the blood corpuscles with difficulty, and the fever was slight compared with the high and persistent fever of the rhesus monkey. In both the swelling of the lymph glands was an early symptom and constantly present. Definite anemia developed in the chimpanzee only after accidental infection with Rocky Mountain spotted fever and may have been due to either one or both infections, though it disappeared when the blood had become negative by culture for Bartonella bacilliformis and the local lesions had disappeared. Incidentally, the chimpanzee was found in this one instance to be less susceptible to the spotted fever than Macacus rhesus and guinea pigs. In the ourang-utan, also, Bartonella bacilliformis induced a mild systemic and local infection. A rise of temperature occurred 10 days after inoculation) and fever continued for a week, though it was decidedly less severe than that in the control rhesus. The lesions induced by scarification were less definite than those which arose at the sites of intradermal inoculation. Bartonella bacilliformis was recovered from the blood on the 9th and on the 16th days after inoculation and from nodules excised on the 33rd and 53rd days. A few erythrocytes containing the organism were demonstrated in stained smears, but prolonged search was required to find them. The symptoms and lesions observed in the chimpanzee and ourangutan as a result of infection with Bartonella bacilliformis are far milder than those of rhesus monkeys and show less resemblance to human Oroya fever or verruga.

37 citations

Journal ArticleDOI
TL;DR: It is concluded that certain phlebotomi act as insect vectors of Oroya fever and verruga peruana, while Phlebotomus peruensis remains doubtful in this respect.
Abstract: With a view to determining the mode of infection in Carrion's disease, a study of the blood-sucking insects found in the districts of Peru where the disease prevails has been carried out, through the cooperation of The Rockefeller Institute and the Rockefeller Foundation. The material studied included ticks, mites, midges, lice, fleas, bedbugs, mosquitoes, buffalo gnats, horse-flies, "sheep ticks," 3 species of Streblidae, and 3 species of Phlebotomus, including Phlebotomus verrucarum Townsend and two new species which have been named Phlebotomus noguchii and Phlebotomus peruensis. The insects were collected without the use of chemicals, were prepared for transportation in such a manner as to prevent drying, and were shipped under conditions of refrigeration to New York, where they were inoculated into monkeys. The plan followed was to inject saline suspensions of the crushed insects intradermally into rhesus monkeys and to make cultures of the blood of the animals at intervals of 1 to 6 weeks after inoculation. The only class of insects in which the presence of Bartonella bacilliformis could be detected were phlebotomi. No cutaneous lesions were induced in monkeys injected with the crushed insects, but in the case of four different lots of phlebotomi the blood of the animals so injected yielded cultures of Bartonella bacilliformis which produced typical verrucous lesions on inoculation into other monkeys. The morphology and cultural characteristics of the Bartonella strains obtained from phlebotomi proved identical with those of strains isolated from human blood and skin lesions. Monkeys which had recovered from infection with the phlebotomus strains resisted inoculation with a human strain of Bartonella bacilliformis, and, conversely, monkeys which had passed through an infection induced by the human strain resisted inoculation with the strains obtained from phlebotomi. The experimental observations described in this paper lead us to conclude that certain phlebotomi act as insect vectors of Oroya fever and verruga peruana. The phlebotomi which have been shown quite certainly to carry the Bartonella bacilliformis are those of the species Phlebotomus noguchii. Phlebotomus verrucarum is also probably a vector, while Phlebotomus peruensis remains doubtful in this respect.

33 citations

Journal ArticleDOI
TL;DR: The infection transmitted by the ticks was mild, but definite, as shown by the recovery of Bartonella bacilliformis from the lymph nodes and blood.
Abstract: Experiments are reported in which Bartonella bacilliformis was transmitted from infected to normal rhesus monkeys by the bite of the tick, Dermacentor andersoni. A long period of feeding, both on the infected animal and on the normal animal subjected to infection, was required in order to secure positive results. The infection transmitted by the ticks was mild, but definite, as shown by the recovery of Bartonella bacilliformis from the lymph nodes and blood.

30 citations

Journal ArticleDOI
08 Nov 1913-JAMA
TL;DR: The expedition was undertaken for the purpose of investigating certain obscure forms of tropical disease in South America, particularly verruga peruviana, as well as with the idea of collecting material to be used for the instruction of students in the various courses of tropical medicine to be inaugurated at Harvard University in November of the present year.
Abstract: The expedition was undertaken for the purpose of investigating certain obscure forms of tropical disease in South America, particularly verruga peruviana, as well as with the idea of collecting material to be used for the instruction of students in the various courses of tropical medicine to be inaugurated at Harvard University in November of the present year. After proceeding to Colon and Panama we continued down the west coast of South America to Buenaventura, Colombia, and thence to Guayaquil. In Buenaventura, Guayaquil and the vicinity, material relating to biting insects, animal parasites, caraate, frambesia, plague, malaria and particularly yellow fever was collected. The studies carried on in relation to these localities will be considered in the complete report of the expedition to be made at a later date. From Guayaquil we proceeded to Peru, where at Lima, and in a number of the mountain towns in the interior, the major

27 citations