Vicoside A, a 28-nortriterpenoid glucoside from Vicoa indica☆
TL;DR: Vicoside A, a new 28-nortriterpenoid glucoside has been isolated from the alcohol extract of the aerial parts of Vicoa indica and its structure was elucidated as 2β,3β,16β,23-tetrahydroxy-17β-formyloxy-28-norolean-12-ene 3- O -β- d -glucopyransoside by spectral data and chemical conversions.
Abstract: Vicoside A, a new 28-nortriterpenoid glucoside has been isolated from the alcohol extract of the aerial parts of Vicoa indica and its structure was elucidated as 2β,3β,16β,23-tetrahydroxy-17β-formyloxy-28-norolean-12-ene 3- O -β- d -glucopyransoside by spectral data and chemical conversions.
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TL;DR: This review provides a comprehensive summary of medicinal flora inhabitating throughout the world regarding their traditional usage by various tribes/ethnic groups for fertility regulation in females and indicates that it is time to increase the number of experimental studies to find out novel potential chemical entities from such a vast array of unexploited plants.
Abstract: Ethnopharmacological relevance Traditional medicines are practiced worldwide for regulation fertility since ancient times. This review provides a comprehensive summary of medicinal flora inhabitating throughout the world regarding their traditional usage by various tribes/ethnic groups for fertility regulation in females. Materials and methods Bibliographic investigation was carried out by analyzing classical text books and peer reviewed papers, consulting worldwide accepted scientific databases from the last six decades. Plants/their parts/extracts traditionally used for abortion, contraception, emmenagogue and sterilization purposes have been considered as antifertility agents. Research status of selected potential plant species has been discussed. Further, compounds isolated from plants with attributed fertility regulating potentials are also classified into three categories: (a) phytoconstituents with anti-implantation activity, (b) phytoconstituents with abortifacient activity and (c) phytoconstituents with contraceptive activity. Results 577 plant species belonging to 122 families, traditionally used in fertility regulation in females, have been recorded, of which 298 plants have been mentioned as abortifacients (42%), 188 as contraceptives (31%), 149 as emmenagogues (24%), and 17 as sterilizers. Among 122 plant families, fabaceae constitutes 49.2%, asteraceae 40.98%, euphorbiaceae 19.7%, apiaceae 16.4%, poaceae 12.3%, labiateae 11.5%, and others in lesser proportion. Various plant parts used in fertility regulation include leaves (25%), roots (22%), fruits (15%), seeds (12%), stem/stem bark (37%), and flowers (4%). Some active compounds, isolated from about various plant species, have been reported to possess significant antifertility potential. Conclusion This review clearly indicates that it is time to increase the number of experimental studies to find out novel potential chemical entities from such a vast array of unexploited plants having traditional role in fertility regulation. Also, the mechanisms of action by which plant extracts and their active compounds exert antifertility effects remain to be studied.
137 citations
TL;DR: The aerial parts of Vicoa pentanema yielded four new sesquiterpene lactones, namely, 10α-hydroxy-14H-inuviscolide (1), 4α,5α-epoxy-10α,11β,13H, 14H-1-epi-inviscolides 3-β-d-glucoside (2), 2α-O-acety...
Abstract: The aerial parts of Vicoa pentanema yielded four new sesquiterpene lactones, namely, 10α-hydroxy-14H-inuviscolide (1), 4α,5α-epoxy-10α,11β,13H,14H-1-epi-inuviscolide 3-β-d-glucoside (2), 2α-O-acety...
38 citations
Journal Article•
TL;DR: Hexane and aqueous extracts showed several degrees of antibacterial properties against E. coli, K. pneumoniae and Vibrio parahaemolyticus, which prove the potentiality of the plant extract for the treatment of various infections.
Abstract: The aim of the present research was focused on the antibacterial, preliminary phytochemical and pharmacognostical properties of Vicoa indica (L.)DC. via in vitro approach. The aqueous and organic solvent (hexane, chloroform and methanol) extracts from the leaves of Vicoa indica (Asteraceae) were tested against Escherichia coli, Klebsiella pneumoniae, Salmonella typhi, Vibrio parahaemolyticus, Vibrio cholerae, Bacillus subtilis and Streptococcus pneumoniae by agar cup plate method. The results showed promising antibacterial activity against the bacteria tested. Among these, hexane and aqueous extracts were found to have a more potent inhibitory effect comparing with the other extracts. Hexane and aqueous extracts showed several degrees of antibacterial properties against E. coli, K. pneumoniae and S. typhi. The chloroform extract expresses the maximum zone of inhibition against K. pneumoniae, E. coli, S. pneumoniae, S. typhi and B. subtilis; showing effectiveness of this extract for the treatment of infectious diseases. The methanol extracts exhibit excellent activity against E. coli, K. pneumoniae and Vibrio parahaemolyticus, which prove the potentiality of the plant extract for the treatment of various infections. This study includes preliminary phytochemical and pharmacognostic investigations on the taxon.
24 citations
TL;DR: The aerial parts of Vicoa indica afforded a new sesquiterpene lactone as its acetate, the structure and relative stereochemistry of which was established by spectral data including X-ray crystallographic analysis.
Abstract: The aerial parts of Vicoa indica afforded a new sesquiterpene lactone as its acetate (1) the structure and relative stereochemistry of which was established by spectral data including X-ray crystallographic analysis.
5 citations
TL;DR: Vicogenin, a new triterpenoid, has been isolated from the chloroform extract of Vicoa indica and its structure assigned as 28-nor-12-oleanene-2β,3β,16β,23-pentol on the basis of its spectroscopic properties.
Abstract: Vicogenin, a new triterpenoid, has been isolated from the chloroform extract of Vicoa indica and its structure assigned as 28-nor-12-oleanene-2β,3β,16β,23-pentol on the basis of its spectroscopic properties.
4 citations
References
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93 citations
TL;DR: A new 1α-hydroxy pentacyclic triterpenoid acid, imberbic acid, has been isolated from the leaves of Combretum imberbe and its structure established as 1α,3β-dihydroxyolean-12-en-29-oic acid by chemical and spectral analysis as mentioned in this paper.
Abstract: A new 1α-hydroxy pentacyclic triterpenoid acid, imberbic acid, has been isolated from the leaves of Combretum imberbe and its structure established as 1α,3β-dihydroxyolean-12-en-29-oic acid by chemical and spectral analysis.
29 citations
TL;DR: Two sapogenins isolated from MELANDRIUM FIRMUM are shown to have the structures of 3beta,21beta-dihydroxy-16,23,dioxo-28-nor-Nor-17alpha,18beta-olean-12-ene and 3beta-16alpha-dHYDroxy-23-oxo-olean(18)-en- 28-oic acid, respectively.
Abstract: Two sapogenins isolated from MELANDRIUM FIRMUM are shown to have the structures of 3beta,21beta-dihydroxy-16,23,dioxo-28-nor-17alpha,18beta-olean-12-ene and 3beta-16alpha-dihydroxy-23-oxo-olean-13(18)-en-28-oic acid, respectively by spectral data and X-ray crystallographic analysis.
19 citations
TL;DR: The saponin from the berries of Phytolacca americana yielded one known and two new aglycones, desmethylphytolaccagenin 2 and 3β, 23-dihydroxyolean-12-ene-28, 30-dioic acid-30-methyl ester 3.
Abstract: The saponin from the berries of Phytolacca americana yielded one known and two new aglycones. One of the new aglycones was identified as desmethylphytolaccagenin 2 , and the other as 3β, 23-dihydroxyolean-12-ene-28, 30-dioic acid-30-methyl ester 3 .
17 citations
13 citations