Journal ArticleDOI
VIP-, SS-, and GABA-like immunoreactivity in the mid-hippocampal region of El (epileptic) and C57BL/6 mice.
Joseph T. King,Carole C. Lamotte +1 more
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TLDR
Specific interneuron populations with VIP-LI and GABA-LI were elevated in the El mice, whereas SS-LI populations were unchanged, suggesting neurochemical alterations may be contributing to the epileptic predisposition of El mice.About:
This article is published in Brain Research.The article was published on 1988-12-13. It has received 16 citations till now. The article focuses on the topics: Vasoactive intestinal peptide.read more
Citations
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Journal ArticleDOI
GABAergic mechanisms in epilepsy.
TL;DR: Gamma-Aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the cerebral cortex, maintains the inhibitory tone that counterbalances neuronal excitation when this balance is perturbed, seizures may ensue.
Journal ArticleDOI
VIP: molecular biology and neurobiological function.
TL;DR: VIP is a major factor in brain activity, neuroendocrine functions, cardiac activity, respiration, digestion, and sexual potency, and exerts its function via receptor-mediated systems, activating signal transduction pathways, including cAMP.
Journal ArticleDOI
Animal models of inherited epilepsy.
TL;DR: A variety of models exist to study the genetic, biochemical, structural and electrophysiological mechanisms that underlie the predisposition and expression of the inherited epilepsies.
Journal ArticleDOI
El mouse as a model of focal epilepsy: a review.
Joseph T. King,Carole C. Lamotte +1 more
TL;DR: The El mouse is a model of hereditary sensory precipitated temporal lobe epilepsy that has a decreased threshold for convulsion by electrical or pharmacologic stimulation and subtle differences in the thalamus and hippocampus of El mice.
Journal ArticleDOI
GABA neurons in seizure disorders: a review of immunocytochemical studies.
TL;DR: Differing between different classes of GABA neurons and determining their functional roles represent major challenges for future studies of GABA neuron in seizure disorders.
References
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Journal ArticleDOI
Decreased hippocampal inhibition and a selective loss of interneurons in experimental epilepsy.
TL;DR: Results suggest that the seizure-induced loss of a basket cell-activating system, rather than a loss of inhibitory basket cells themselves, may cause disinhibition and thereby play a role in the pathophysiology and pathology of the epileptic state.
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Commissural connections of the hippocampal region in the rat, with special reference to their mode of termination
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First visualization of glutamate and GABA in neurones by immunocytochemistry
Jon Storm-Mathisen,Alfhild Kristine Leknes,Anna Torbjørg Bore,Jorunn Line Vaaland,Paul Edminson,Finn-Mogens S. Haug,Ole Petter Ottersen +6 more
TL;DR: Selective immunocytochemical visualization of the putative transmitters glutamate and γ-aminobutyrate by the use of antibodies raised against the amino acids coupled to bovine serum albumin with glutaraldehyde suggests that the transmitter amino acids are significantly concentrated in synaptic vesicles.
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Immunocytochemical localization of glutamic acid decarboxylase in neuronal somata following colchicine inhibition of axonal transport
TL;DR: A reasonable explanation for the failure of earlier immunocytological studies to detect somal GAD in certain GABAergic neurons is that the axonal transport of GAD appears to occur at a sufficiently rapid rate to limit the somal concentration of G AD to low, undetectable levels.
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Immunocytochemical localization of GABA-, cholecystokinin-, vasoactive intestinal polypeptide-, and somatostatin-like immunoreactivity in the area dentata and hippocampus of the rat
TL;DR: Findings in the area dentata indicate that two main populations of interneurons can be discriminated on the basis of the substances they contain, and that SS‐LI hilar cells apparently form part of the dentate ipsilateral associational/commissural projections.