Viper venom-induced inflammation and inhibition of free radical formation by pure compound (2-hydroxy-4-methoxy benzoic acid) isolated and purified from anantamul (Hemidesmus indicus R.Br) root extract
TL;DR: The present investigation explored the possible venom neutralizing effect of a pure compound isolated and purified from the methanolic root extract of Hemidesmus indicus R.Rr.
About: This article is published in Toxicon.The article was published on 1998-01-01. It has received 112 citations till now. The article focuses on the topics: Hemidesmus indicus.
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01 Jan 2013
TL;DR: This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the phytomedicine of citrus fruits and its applications in the context of wound healing.
Abstract: Author for correspondence: Professor A. Subramoniam Former Director, Tropical Botanic Garden and Research Institute, Thiruvananthapuram-695562, Kerala, India Residence: Vininivas, T.C. 14/80, Anyara (P.O.), Near KIMS Hospital, Thiruvananthapuram-695029, Kerala, India E-mail: asubramoniam@yahoo.com Tel.: +91-09496093609 ANNALS OF PHYTOMEDICINE An International Journal Annals of Phytomedicine 2(1): 3-36, 2013 ISSN 2278-9839
35 citations
Cites background from "Viper venom-induced inflammation an..."
...Hemidesmus indicus (L.) Ethanol extract of root Antiadjuvant induced Metha et al., 2012; R.Br.Asclepiadaceae arthritis in rats; Inhibi- Alam and Gomes, 1998 tion of inflammation induced by viper venom 33....
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TL;DR: Pretreatment with Arogh offered a protective effect against isoproterenol induced myocardial damage in rats as evidenced by LDH isoenzyme patterm and histopathological studies of heart tissue.
Abstract: To study the protective role of Arogh on isoproterenol induced myocardial damage in rats. The effect of Arogh pretreatment on isoproterenol induced myocardial damage was assessed by studying the levels of lipid peroxides and changes in the activity of marker enzymes such as creatine kinase, lactate dehydrogenase and transaminases in serum and heart tissue. In isoproterenol administered rats, a significant decrease was observed in the activity of marker enzymes in the heart with a corresponding increase in their levels in serum. Lipid peroxide levels increased significantly in the serum and heart. In rats pretreated with arogh, the level of lipid peroxides and the activity of marker enzymes were maintained at near normal values. Pretreatment with Arogh offered a protective effect against isoproterenol induced myocardial damage in rats as evidenced by LDH isoenzyme patterm and histopathological studies of heart tissue.
34 citations
TL;DR: PLE possesses good anti-snake venom properties and piperine is one of the compounds responsible for the effective venom neutralizing ability of the plant.
34 citations
TL;DR: 15 plant species were found to be used by the ethnic groups as anti-snake venom ousethnobotanicals in the villages of Purulia.
Abstract: Purulia, the westernmost district of West Bengal, India is inhabited by a large number of tribals. A study on ethnomedicinal plants used against snakebite in the villages of the district was carried out. Using a questionnaire, personal interviews, and conversations, 15 plant species were found to be used by the ethnic groups as anti-snake venom ousethnobotanicals. Information, mostly collected from villagers, was documented with scientific names of the plants, families, vernacular names, parts used, mode of administration, and locality of use. A note on other reports of the plants used as antivenom and their pharmacological significance were added to bridge the traditional knowledge and scientific investigations.
32 citations
TL;DR: Hemidesmus indicus root extract possesses significant genoprotective effect at the lower concentrations although it is cytotoxic and probably genotoxic at higher doses.
31 citations
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TL;DR: The staining procedure for localizing superoxide dismutase on polyacrylamide electrophoretograms has been applied to extracts obtained from a variety of sources and could thus be assayed either in crude extracts or in purified protein fractions.
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TL;DR: The few existing reports on the careful pharmacodynamic, pharmacokinetic and clinical studies which have been made have been summarized to provide a basis for a full-scale investigation of the therapeutic potential of flavonoids.
1,605 citations
TL;DR: It is shown that similar events occur in the guinea pig perfused lung before inhibition by steroids of phospholipase A2 activity (and thus TXA2 generation), and a steroid-induced factor is discovered which mimics the anti-phospholipases effects of these anti-inflammatory agents.
Abstract: ASPIRIN prevents prostaglandin (PG) generation by directly inhibiting the cyclo-oxygenase enzyme responsible for PG biosynthesis1–3. In addition, there is now conclusive evidence that anti-inflammatory steroids can also prevent PG generation4–13. Unlike the aspirin-like drugs, steroids have no anti-cyclo-oxygenase activity but exert their action by preventing the release from phospholipids of the fatty acid substrates required for PG biosynthesis4–9,12,13. We have shown that stimulation of thromboxane A2 (TXA2) release by agents such as histamine, 5-hydroxytryptamine and rabbit aorta contracting substance-releasing factor (RCS–RF) (but not arachidonic acid) is inhibited by anti-inflammatory steroids, and that their potency in this action closely parallels their anti-inflammatory activity12,13. Furthermore, their mechanism of action involves the inhibition of phospholipase A2 activity, and thus of arachidonate release within the lung12,13. In several other tissues, the mechanism of steroid hormone action depends on the combination of thesteroid with a cytosolic receptor protein, the translocation of this drug–receptor complex to the nucleus and the initiation of protein biosynthesis14–16. We now show that similar events occur in the guinea pig perfused lung before inhibition by steroids of phospholipase A2 activity (and thus TXA2 generation). We have discovered a steroid-induced factor which mimics the anti-phospholipase effects of these anti-inflammatory agents.
891 citations