Vitamin D and the immune system.
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TLDR
As immune cells in autoimmune diseases are responsive to the ameliorative effects of vitamin D, the beneficial effects of supplementing vitamin D-deficient individuals with autoimmune disease may extend beyond the effects on bone and calcium homeostasis.Abstract:
It is now clear that vitamin D has important roles in addition to its classic effects on calcium and bone homeostasis. As the vitamin D receptor is expressed on immune cells (B cells, T cells, and antigen-presenting cells), and these immunologic cells are all capable of synthesizing the active vitamin D metabolite, vitamin D has the capability of acting in an autocrine manner in a local immunologic milieu. Vitamin D can modulate the innate and adaptive immune responses. Deficiency in vitamin D is associated with increased autoimmunity and an increased susceptibility to infection. As immune cells in autoimmune diseases are responsive to the ameliorative effects of vitamin D, the beneficial effects of supplementing vitamin D-deficient individuals with autoimmune disease may extend beyond the effects on bone and calcium homeostasis.read more
Citations
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References
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Journal ArticleDOI
Vitamin D Deficiency
TL;DR: The role of vitamin D in skeletal and nonskeletal health is considered and strategies for the prevention and treatment ofitamin D deficiency are suggested.
Journal ArticleDOI
Vitamin D deficiency.
TL;DR: It is suggested that if assessment of overdoses were left to house doctors there would be an increase in admissions to psychiatric units, outpatients, and referrals to social services, but for house doctors to assess overdoses would provide no economy for the psychiatric or social services.
Journal ArticleDOI
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
Philip T. Liu,Steffen Stenger,Huiying Li,Linda Wenzel,Belinda H. Tan,Stephan R. Krutzik,Maria Teresa Ochoa,Jürgen Schauber,Kent Wu,Christoph Meinken,Diane L. Kamen,Manfred Wagner,Robert Bals,Andreas Steinmeyer,Ulrich Zügel,Richard L. Gallo,David Eisenberg,Martin Hewison,Bruce W. Hollis,John S. Adams,Barry R. Bloom,Robert L. Modlin +21 more
TL;DR: The data support a link between TLRs and vitamin D–mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection.
Journal ArticleDOI
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
Emily C. Baechler,Franak Batliwalla,George Karypis,Patrick M. Gaffney,Ward A. Ortmann,Karl J. Espe,Katherine B. Shark,William J. Grande,Karis M. Hughes,Vivek Kapur,Peter K. Gregersen,Timothy W. Behrens +11 more
TL;DR: Global gene expression profiling of peripheral blood mononuclear cells is used to identify distinct patterns of gene expression that distinguish most SLE patients from healthy controls, and identify a subgroup of patients who may benefit from therapies targeting the IFN pathway.
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Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
Lynda Bennett,A. Karolina Palucka,Edsel Arce,Edsel Arce,Victoria Cantrell,Victoria Cantrell,Josef Borvak,Jacques Banchereau,Virginia Pascual,Virginia Pascual +9 more
TL;DR: Microarray analysis of blood cells reveals that immature granulocytes may be involved in SLE pathogenesis, and the IFN signature confirms the central role of this cytokine in Sle, using oligonucleotide microarrays.
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