Journal ArticleDOI
Vitamin E: Emerging aspects and new directions.
Francesco Galli,Angelo Azzi,Marc Birringer,Joan M. Cook-Mills,Manfred Eggersdorfer,Jan Frank,Gabriele Cruciani,Stefan Lorkowski,Nesrin Kartal Ozer +8 more
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TLDR
New insights are presented on the mechanisms of reduction of the cardiovascular risk, immunomodulation and antiallergic effects, neuroprotection properties in models of glutamate excitotoxicity and spino‐cerebellar damage, hepatoprotection and prevention of liver toxicity by different causes and even therapeutic applications in non‐alcoholic steatohepatitis.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2017-01-01. It has received 318 citations till now. The article focuses on the topics: Fat-Soluble Vitamin & Vitamin E.read more
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Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications
Jacek Zielonka,Joy Joseph,Adam Sikora,Micael Hardy,Olivier Ouari,Jeannette Vasquez-Vivar,Gang Cheng,Marcos Lopez,Balaraman Kalyanaraman +8 more
TL;DR: The physicochemical basis for mitochondrial accumulation of lipophilic cations, synthetic chemistry strategies to target compounds to mitochondria, mitochondrial probes, and sensors, and examples of mitochondrial targeting of bioactive compounds are described.
Journal ArticleDOI
Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases
TL;DR: A better understanding of the role of antioxidants involved in redox modulation of inflammation would provide a useful approach for potential interventions, and subsequently promoting healthy longevity.
Journal ArticleDOI
Ageing, age-related diseases and oxidative stress: What to do next?
TL;DR: It is proposed that oxidized vitamin E metabolites may be used to accurately monitor individual functional antioxidant level, which might serve as promising key solutions for future elucidating the impact of oxidative stress on ageing and age-related diseases.
Journal ArticleDOI
RBOH-Dependent ROS Synthesis and ROS Scavenging by Plant Specialized Metabolites To Modulate Plant Development and Stress Responses.
TL;DR: The unique properties of plant specialized metabolites, including carotenoids, ascorbate, tocochromanols (vitamin E), and flavonoids, in modulating ROS homeostasis are summarized.
Journal ArticleDOI
Nutrigenomics of extra-virgin olive oil: A review.
Marta Piroddi,Adriana Albini,Roberto Fabiani,Lisa Giovannelli,Cristina Luceri,Fausta Natella,Patrizia Rosignoli,Teresa Rossi,Agnese Taticchi,Maurizio Servili,Francesco Galli +10 more
TL;DR: Gene regulation properties of the functional components of olive oil, such as oleic acid, biophenols and vitamin E, point to a role for these molecules as natural homeostatic and even hormetic factors with applications as prevention agents in conditions of premature and pathologic aging.
References
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Journal ArticleDOI
The Ubiquitin System
Avram Hershko,Aaron Ciechanover +1 more
TL;DR: This review discusses recent information on functions and mechanisms of the ubiquitin system and focuses on what the authors know, and would like to know, about the mode of action of ubi...
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Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis
Arun J. Sanyal,Naga Chalasani,Kris V. Kowdley,Arthur J. McCullough,Anna Mae Diehl,Nathan M. Bass,Brent A. Neuschwander-Tetri,Joel E. Lavine,James Tonascia,Aynur Unalp,Mark L. Van Natta,Jeanne M. Clark,Elizabeth M. Brunt,David E. Kleiner,Jay H. Hoofnagle,Patricia R. Robuck +15 more
TL;DR: Vitamin E was superior to placebo for the treatment of nonalcoholic steatohepatitis in adults without diabetes, and significant benefits of pioglitazone were observed for some of the secondary outcomes.
Journal ArticleDOI
A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study
Mary Sano,Christopher Ernesto,Ronald G. Thomas,Melville R. Klauber,Kimberly Schafer,Michael Grundman,Peter B. Woodbury,John H. Growdon,Carl W. Cotman,Eric Pfeiffer,Lon S. Schneider,Leon J. Thal +11 more
TL;DR: In patients with moderately severe impairment from Alzheimer's disease, treatment with selegiline or alpha-tocopherol slows the progression of disease.
Journal ArticleDOI
Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality
Edgar R. Miller,Roberto Pastor-Barriuso,Darshan Dalal,Rudolph A. Riemersma,Lawrence J. Appel,Eliseo Guallar +5 more
TL;DR: This meta-analysis of 19 randomized, controlled trials involving more than 135000 participants found that high-dosage vitamin E supplementation (400 IU/d for at least 1 year) increased all-cause mortality.
Journal ArticleDOI
Basic Medical Research Award. The ubiquitin system.
TL;DR: The ubiquitin system plays important roles in the control of numerous processes, including cell-cycle progression, signal transduction, transcriptional regulation, receptor down-regulation, and endocytosis as mentioned in this paper.
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