Patent
Water-soluble strontium salts for use in treatment of cartilage and/or bone conditions
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TLDR
Water-soluble strontium salts have a water-solubility of from about 1 g/l to about 100 g/L at room temperature as mentioned in this paper. But they are not suitable for use in the treatment and/or prophylaxis of cartilage and bone conditions and for methods of treating such condition.Abstract:
Compounds and pharmaceutical compositions for use in the treatment and/or prophylaxis of cartilage and/or bone conditions and for methods of treating such condition. The compounds are salts of strontium that have a water-solubility of from about 1 g/l to about 100 g/l at room temperature, especially amino acid salts of strontium or dicarboxylic acid salts of strontium. Examples of novel water-soluble strontium salts are e.g. strontium glutamate and strontium alpha-ketoglutarate. The present invention also relates to an improved method for preparing the strontium salt of glutamic acid.read more
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Crystal Nucleation of Nano Crystallite Strontium Malonate without and with Additives
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References
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Book
The Merck Manual of Diagnosis and Therapy
Mark H. Beers,Robert Berkow +1 more
TL;DR: The world's most widely used medical reference now features expanded clinical focus on each category of disorder, as well as more specific guidance on patient examinations, in the thoroughly revised and updated 18th Edition.
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The Effects of Strontium Ranelate on the Risk of Vertebral Fracture in Women with Postmenopausal Osteoporosis
Pierre J. Meunier,Christian Roux,Ego Seeman,Sergio Ortolani,J. Badurski,Tim D. Spector,J. Cannata,Adam Balogh,EM Lemmel,S. Pors-Nielsen,René Rizzoli,Harry K. Genant,Jean-Yves Reginster +12 more
TL;DR: Treatment of postmenopausal osteoporosis with strontium ranelate leads to early and sustained reductions in the risk of vertebral fractures.
Journal ArticleDOI
Mechanisms of action and therapeutic potential of strontium in bone
TL;DR: In addition to its antiresorptive activity, strontium was found to have anabolic activity in bone, and this may have significant beneficial effects on bone balance in normal and osteopenic animals.
Journal ArticleDOI
Incorporation and distribution of strontium in bone.
S.G Dahl,P Allain,Pierre J. Marie,Y Mauras,Georges Boivin,Patrick Ammann,Yannis Tsouderos,Pierre D. Delmas,Claus Christiansen +8 more
TL;DR: Infiltration of strontium into bone, mainly by exchange onto the crystal surface, is dependent on the duration of treatment, dose, gender, and skeletal site, and, in bone, between the different skeletal sites.
Journal ArticleDOI
The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro.
TL;DR: The data indicate that the divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro, an effect that may contribute to the previously reported effects of S12912 on trabecular bone mass in vivo.