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Journal ArticleDOI

Wearable and Miniaturized Sensor Technologies for Personalized and Preventive Medicine

01 Apr 2017-Advanced Functional Materials (Wiley)-Vol. 27, Iss: 15, pp 1605271
TL;DR: A review of achievements and standing challenges for the development of non‐invasive personalized and preventive medicine devices and directions for future research in miniaturized medical sensor technologies are provided.
Abstract: The unprecedented medical achievements of the last century have dramatically improved our quality of life. Today, the high cost of many healthcare approaches challenges their long-term financial sustainability and translation to a global scale. The convergence of wearable electronics, miniaturized sensor technologies, and big data analysis provides novel opportunities to improve the quality of healthcare while decreasing costs by the very early stage detection and prevention of fatal and chronic diseases. Here, some exciting achievements, emerging technologies, and standing challenges for the development of non-invasive personalized and preventive medicine devices are discussed. The engineering of wire- and power-less ultra-thin sensors on wearable biocompatible materials that can be placed on the skin, pupil, and teeth is reviewed, focusing on common solutions and current limitations. The integration and development of sophisticated sensing nanomaterials are presented with respect to their performance, showing exemplary implementations for the detection of ultra-low concentrations of biomarkers in complex mixtures such as the human sweat and breath. This review is concluded by summarizing achievements and standing challenges with the aim to provide directions for future research in miniaturized medical sensor technologies.
Citations
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Journal ArticleDOI
TL;DR: Electroanalysis as chemical sensors in solution, gas phase, and chiral molecules for conducting polymers applications is focused exclusively on energy, use in environmental remediation, and adsorption of pollutants.
Abstract: Conducting polymers (CPs), thanks to their unique properties, structures made on-demand, new composite mixtures, and possibility of deposit on a surface by chemical, physical, or electrochemical methodologies, have shown in the last years a renaissance and have been widely used in important fields of chemistry and materials science. Due to the extent of the literature on CPs, this review, after a concise introduction about the interrelationship between electrochemistry and conducting polymers, is focused exclusively on the following applications: energy (energy storage devices and solar cells), use in environmental remediation (anion and cation trapping, electrocatalytic reduction/oxidation of pollutants on CP based electrodes, and adsorption of pollutants) and finally electroanalysis as chemical sensors in solution, gas phase, and chiral molecules. This review is expected to be comprehensive, authoritative, and useful to the chemical community interested in CPs and their applications.

319 citations

Journal ArticleDOI
TL;DR: In this paper, the development of high performance light-emitting devices with flexible and stretchable form factors is described. But the development is mainly achieved by replacing the rigid materials in the device components with flex...
Abstract: Recent technological advances in nanomaterials have driven the development of high‐performance light‐emitting devices with flexible and stretchable form factors. Deformability in such devices is mainly achieved by replacing the rigid materials in the device components with flex...

310 citations

Journal ArticleDOI
TL;DR: This Review aims to comprehend the sensing mechanisms and the synergistic effects of various hybridizations of 2D TMDs and metal oxides, and to clearly understand the collective benefits of TMD's and metal oxide hybrids.
Abstract: Two-dimensional (2D) nanomaterials have demonstrated great potential in the field of gas sensing due to their layered structures. Especially for 2D transition metal dichalcogenides (TMDs), inherent high surface areas and their unique semiconducting properties with tunable band gaps make them compelling for sensing applications. In combination with the general benefits of 2D nanomaterials, the incorporation of metal oxides into 2D TMDs is a recent approach for improving the gas sensing performance of these materials by the synergistic effects of the hybridization. This Review aims to comprehend the sensing mechanisms and the synergistic effects of various hybridizations of 2D TMDs and metal oxides. The Review begins with the gas sensing mechanisms and synthesis methods of 2D TMDs. Achievements in recent research on 2D TMDs and their metal oxide hybrids for sensor applications are then comprehensively compiled. To clearly understand the collective benefits of TMDs and metal oxide hybrids, the hybridization effects are discussed in three aspects: geometrical, electronic, and chemical effects.

305 citations

Journal ArticleDOI
11 Feb 2019-ACS Nano
TL;DR: A self-powered and self-functional sock (S2-sock) to realize diversified functions including energy harvesting and sensing various physiological signals, i.e., gait, contact force, sweat level, etc., by hybrid integrating poly(3,4-ethylenedioxythiophene) polystyrenesulfonate (PEDOT:PSS)-coated fabric triboelectric nanogenerator (TENG) and lead zirconate titanate
Abstract: Wearable devices rely on hybrid mechanisms that possess the advantages of establishing a smarter system for healthcare, sports monitoring, and smart home applications. Socks with sensing capabilities can reveal more direct sensory information on the body for longer duration in daily life. However, the limitation of suitable materials for smart textile makes the development of multifunctional socks a major challenge. In this paper, we have developed a self-powered and self-functional sock (S2-sock) to realize diversified functions including energy harvesting and sensing various physiological signals, i.e., gait, contact force, sweat level, etc., by hybrid integrating poly(3,4-ethylenedioxythiophene) polystyrenesulfonate (PEDOT:PSS)-coated fabric triboelectric nanogenerator (TENG) and lead zirconate titanate (PZT) piezoelectric chips. An output power of 1.71 mW is collected from a PEDOT:PSS-coated sock with mild jumping at 2 Hz and load resistance of 59.7 MΩ. The study shows that cotton socks worn daily can potentially be a power source for enabling self-sustained socks comprising wireless transmission modules and integrated circuits in the future. We also investigate the influences of environmental humidity, temperature, and weight variations and verify that our S2-sock can successfully achieve walking pattern recognition and motion tracking for smart home applications. On the basis of the sensor fusion concept, the outputs from TENG and PZT sensors under exercise activities are effectively merged together for quick detection of the sweat level. By leveraging the hybrid S2-sock, we can achieve more functionality in the applications of foot-based energy harvesting and monitoring the diversified physiological signals for healthcare, smart homes, etc.

249 citations

Journal ArticleDOI
TL;DR: Recent developments on the application of various types of portable biosensing devices with focus on smartphone-enabled biosensing in which analysis, diagnostics, and communications are coupled are described.
Abstract: Low-cost point-of-care (POC) diagnostics play several critical roles in healthcare strategies, particularly for detection, therapy, economy, health management, and surveillance. Any user can now perform rapid, efficient, inexpensive, and easy analysis anywhere at any time and various kind of hybrid biosensing devices improved the POC analyses. This review describes recent developments on the application of various types of portable biosensing devices with focus on smartphone-enabled biosensing in which analysis, diagnostics, and communications are coupled. Further, we provide an overview of recent biosensing platforms, from optical to electrochemical biosensors and consider future opportunities for POC devices for clinical analysis and infectious diseases assessment.

228 citations

References
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Journal ArticleDOI
Changgu Lee1, Xiaoding Wei1, Jeffrey W. Kysar1, James Hone1, James Hone2 
18 Jul 2008-Science
TL;DR: Graphene is established as the strongest material ever measured, and atomically perfect nanoscale materials can be mechanically tested to deformations well beyond the linear regime.
Abstract: We measured the elastic properties and intrinsic breaking strength of free-standing monolayer graphene membranes by nanoindentation in an atomic force microscope. The force-displacement behavior is interpreted within a framework of nonlinear elastic stress-strain response, and yields second- and third-order elastic stiffnesses of 340 newtons per meter (N m(-1)) and -690 Nm(-1), respectively. The breaking strength is 42 N m(-1) and represents the intrinsic strength of a defect-free sheet. These quantities correspond to a Young's modulus of E = 1.0 terapascals, third-order elastic stiffness of D = -2.0 terapascals, and intrinsic strength of sigma(int) = 130 gigapascals for bulk graphite. These experiments establish graphene as the strongest material ever measured, and show that atomically perfect nanoscale materials can be mechanically tested to deformations well beyond the linear regime.

18,008 citations

Journal ArticleDOI
TL;DR: This review considers current knowledge about the epidemiology and transmission of H. pylori, as well as the role of this infectious agent in the pathogenesis of upper gastrointestinal tract disease.
Abstract: H. pylori is one of the most common bacterial infections in human beings, and its discovery 20 years ago altered the diagnosis and treatment of gastroduodenal disease. This review considers current knowledge about the epidemiology and transmission of H. pylori, as well as the role of this infectious agent in the pathogenesis of upper gastrointestinal tract disease. Diagnostic approaches, indications for therapy, and measures of therapeutic efficacy are reviewed.

2,817 citations

Journal ArticleDOI
TL;DR: In this paper, a review of wearable sensors and systems that are relevant to the field of rehabilitation is presented, focusing on health and wellness, safety, home rehabilitation, assessment of treatment efficacy, and early detection of disorders.
Abstract: The aim of this review paper is to summarize recent developments in the field of wearable sensors and systems that are relevant to the field of rehabilitation. The growing body of work focused on the application of wearable technology to monitor older adults and subjects with chronic conditions in the home and community settings justifies the emphasis of this review paper on summarizing clinical applications of wearable technology currently undergoing assessment rather than describing the development of new wearable sensors and systems. A short description of key enabling technologies (i.e. sensor technology, communication technology, and data analysis techniques) that have allowed researchers to implement wearable systems is followed by a detailed description of major areas of application of wearable technology. Applications described in this review paper include those that focus on health and wellness, safety, home rehabilitation, assessment of treatment efficacy, and early detection of disorders. The integration of wearable and ambient sensors is discussed in the context of achieving home monitoring of older adults and subjects with chronic conditions. Future work required to advance the field toward clinical deployment of wearable sensors and systems is discussed.

1,826 citations

Journal ArticleDOI
TL;DR: An efficient, low-cost fabrication strategy to construct a highly sensitive, flexible pressure sensor by sandwiching ultrathin gold nanowire-impregnated tissue paper between two thin polydimethylsiloxane sheets is reported, enabling facile large-area integration and patterning for mapping spatial pressure distribution.
Abstract: Flexible electronics hold great promise for wearable biomedical sensors. Here, the authors report a pressure sensor composed of gold nanowire-impregnated tissue paper, sandwiched between polydimethylsiloxane sheets, and demonstrate that the design is appropriate for large-area flexible electronics.

1,678 citations

Journal ArticleDOI
TL;DR: Life expectancy in HIV-infected patients treated with combination antiretroviral therapy increased between 1996 and 2005, although there is considerable variability between subgroups of patients.

1,362 citations