WEB (water extract of banana): An efficient natural base for one-pot multi-component synthesis of 2-amino-3,5-dicarbonitrile-6-thio-pyridines
04 Mar 2021-Phosphorus Sulfur and Silicon and The Related Elements (Informa UK Limited)-Vol. 196, Iss: 3, pp 328-336
TL;DR: One-pot multi-component synthesis of 2-amino-3,5-dicarbonitrile-6-thio-pyridines derivatives using WEB (water extract of banana peels ash) as a green catalyst is described in this paper.
Abstract: One-pot multi-component synthesis of 2-amino-3,5-dicarbonitrile-6-thio-pyridines derivatives using WEB (water extract of banana peels ash) as a green catalyst is described. A variety of aromatic al...
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01 Jan 2016
TL;DR: In this article, a continuous flow synthesis (CFS) method is proposed for the efficient, effective and reproducible synthesis of inorganic compounds, and the effect of synthesis route on particle size, size distribution, and crystallinity is compared.
Abstract: Advanced materials are essential to the quality of modern day life, but the synthesis of these compounds is often inefficient in terms of energy, time and resources; especially when considering the hydrothermal batch methods used to prepare many such compounds – often requiring week-long reaction times with variable yields and product quality. In contrast, Continuous flow synthesis (CFS) provides a more readily scalable means for the efficient, effective and reproducible synthesis of inorganic compounds. This publication demonstrates the novel CFS of several metal ammonium phosphates and compare the effect of synthesis route on particle size, size distribution, and crystallinity.
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TL;DR: A review of recycling of ashes from biomass into reagents for chemical synthesis and biodiesel production is given in this paper, where it is shown that the recycling of waste from fossil-and ore-based materials into new materials is called for more recycling.
Abstract: The decline of fossil- and ore-based materials is calling for more recycling of waste into new materials Here, I review the recycling of ashes from biomass into reagents for chemical synthesis and biodiesel production Biomass includes banana, pomegranate, rice, papaya, century plant, water hyacinth, bael fruit, nilgiri, mango, onion, muskmelon fruit, pomelo, lemon fruit, teak and tamarind Chemical reactions include Knoevenagel condensation, Suzuki–Miyaura cross-coupling, Sonogashira reaction, Dakin reaction, Henry reaction, Ullmann coupling, Pd-catalyzed homocoupling, aromatic bromination, hydroxylation of arylboronic acids, hydration of nitriles and azide–alkyne click reaction The synthesis of peptide bonds, disulfides, aminochromenes, carboxycoumarins, diazohydroxy esters, imidazopyridines, pyranopyrazoles, chalcones, flavones and bisenols is described
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TL;DR: A preliminary study of 2-amino-4-aryl-3,5-dicarbonitrile-6-thiopyridines as new potential antimicrobial drugs was performed.
Abstract: A preliminary study of 2-amino-4-aryl-3,5-dicarbonitrile-6-thiopyridines as new potential antimicrobial drugs was performed. Special emphasis was placed on the selection of the structure of target pyridine derivatives with the highest biological activity against different types of Gram-stained bacteria by lipopolysaccharide (LPS). Herein, Escherichia coli model strains K12 (without LPS in its structure) and R2-R4 (with different lengths of LPS in its structure) were used. Studied target compounds were provided with yields ranging from 53% to 91% by the lipase-catalyzed one pot multicomponent reaction of various aromatic aldehydes with malononitrile, and thiols. The presented work showed that the antibacterial activity of the studied pyridines depends on their structure and affects the LPS of bacteria. Moreover, the influence of the pyridines on bacteria possessing smooth and rough LPS and oxidative damage to plasmid DNA caused by investigated compounds was indicated. Additionally, the modification of the bacterial DNA with the tested compounds was performed to detect new potential oxidative damages, which are recognized by the Fpg protein. The obtained damage modification values of the analyzed compounds were compared with the modifications after antibiotics were used in this type of research. The presented studies demonstrate that 2-amino-4-aryl-3,5-dicarbonitrile-6-thiopyridines can be used as substitutes for known antibiotics. The observed results are especially important in the case of the increasing resistance of bacteria to various drugs and antibiotics.
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TL;DR: In this article, the authors highlight the utility of aqueous extracts of agricultural waste in some significant organic transformations, which exclude the need of harmful volatile organic compounds (VOCs) in a number of organic transformations.
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TL;DR: In this paper, the authors present the present-day trends in the catalytic synthesis of 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines are considered using pseudo-four-component reaction (pseudo-4CR) by condensation of malononitrile molecules with thiols and aldehydes, and alternative three-component (3CR) condensations of maloniitrile with S-nucleophiles.
Abstract: This review integrates the published data of the last decade (from 2010 to 2020) on the synthesis of the 2-amino-3,5-dicarbonitrile-6-sulfanylpyridine scaffold, the derivatives of which are widely used in the synthesis of biologically active compounds. Currently, no systematic accounts of synthetic routes towards this class of heterocyclic compounds can be found in the literature. The present-day trends in the catalytic synthesis of 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines are considered using pseudo-four-component reaction (pseudo-4CR) by condensation of malononitrile molecules with thiols and aldehydes, and alternative three-component (3CR) condensations of malononitrile with 2-arylidenemalononitrile and S-nucleophiles.
4 citations
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TL;DR: A review of solution-phase multi-component procedures for the synthesis of heterocyclic compounds can be found in this paper, where the authors give an overview of the progress made in the past decade.
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