scispace - formally typeset
Search or ask a question
Journal ArticleDOI

Westernized diets lower arsenic gastrointestinal bioaccessibility but increase microbial arsenic speciation changes in the colon.

01 Jan 2015-Chemosphere (Chemosphere)-Vol. 119, pp 757-762
TL;DR: Dietary background is a crucial parameter to incorporate when predicting bioavailability with bioaccessibility measurements and when assessing health risks from As following oral exposure.
About: This article is published in Chemosphere.The article was published on 2015-01-01. It has received 40 citations till now.
Citations
More filters
Journal ArticleDOI
TL;DR: A review of emerging issues and research needs to address the multi-faceted challenges related to arsenic and environmental health and suggests integration of omics data with mechanistic and epidemiological data is a key step toward the goal of linking biomarkers of exposure and susceptibility to disease mechanisms and outcomes.
Abstract: Background:Exposure to inorganic and organic arsenic compounds is a major public health problem that affects hundreds of millions of people worldwide. Exposure to arsenic is associated with cancer ...

231 citations


Cites background from "Westernized diets lower arsenic gas..."

  • ...Although bioavailability testing has focused primarily on soils, more research is also warranted for bioavailability assessment of other exposure media such as dust and foods (Alava et al. 2015; Juhasz et al. 2006; Menka et al. 2014)....

    [...]

Journal ArticleDOI
TL;DR: Recent findings indicate that the pre-systematic metabolism by colon microbiota play an important role for human metabolism of arsenicals, and new insight indicates that bioconversion of arsenosugars and arsenolipids in seafood results in urinary excretion of DMA, possibly also producing reactive trivalent arsenic intermediates.

178 citations


Cites background from "Westernized diets lower arsenic gas..."

  • ...Rice may also contain minor amounts of organic As such as DMA (V) [28, 29]....

    [...]

  • ...The iAs in rice is probably present both as As (III) and As (V) [27, 28]....

    [...]

  • ...One recent in vitro study found that dietary composition might have an impact on the presystematic arsenical metabolism; a Westernized diet resulted in higher formation of MA (III) and monomethylmonothio arsonate (MMMTA (V)) than an Asian diet after 48 h incubation of these diets with rice in human colon suspensions [28]....

    [...]

  • ...[28] Alava P, Du Laing G, Tack F, De Ryck T, Van De Wiele T....

    [...]

Journal ArticleDOI
TL;DR: An assessment of the literature indicates that controlling contamination of water sources and plants through effective remediation and management is essential to successfully addressing the problems of arsenic toxicity and contamination.
Abstract: Arsenic is a naturally occurring element with a long history of toxicity. Sites of contamination are found worldwide as a result of both natural processes and anthropogenic activities. The broad scope of arsenic toxicity to humans and its unique interaction with the environment have led to extensive research into its physicochemical properties and toxic behavior in biological systems. The purpose of this review is to compile the results of recent studies concerning the metalloid and consider the chemical and physical properties of arsenic in the broad context of human toxicity and phytoremediation. Areas of focus include arsenic's mechanisms of human toxicity, interaction with plant systems, potential methods of remediation, and protocols for the determination of metals in experimentation. This assessment of the literature indicates that controlling contamination of water sources and plants through effective remediation and management is essential to successfully addressing the problems of arsenic toxicity and contamination.

118 citations

Journal ArticleDOI
12 Oct 2017-Agronomy
TL;DR: Common agronomical practices like rain water harvesting for crop irrigation, use of natural components that help in arsenic methylation, and biotechnological approaches may explore how to reduce arsenic uptake by food crops.
Abstract: According to recent reports, millions of people across the globe are suffering from arsenic (As) toxicity. Arsenic is present in different oxidative states in the environment and enters in the food chain through soil and water. In the agricultural field, irrigation with arsenic contaminated water, that is, having a higher level of arsenic contamination on the top soil, which may affects the quality of crop production. The major crop like rice (Oryza sativa L.) requires a considerable amount of water to complete its lifecycle. Rice plants potentially accumulate arsenic, particularly inorganic arsenic (iAs) from the field, in different body parts including grains. Different transporters have been reported in assisting the accumulation of arsenic in plant cells; for example, arsenate (AsV) is absorbed with the help of phosphate transporters, and arsenite (AsIII) through nodulin 26-like intrinsic protein (NIP) by the silicon transport pathway and plasma membrane intrinsic protein aquaporins. Researchers and practitioners are trying their level best to mitigate the problem of As contamination in rice. However, the solution strategies vary considerably with various factors, such as cultural practices, soil, water, and environmental/economic conditions, etc. The contemporary work on rice to explain arsenic uptake, transport, and metabolism processes at rhizosphere, may help to formulate better plans. Common agronomical practices like rain water harvesting for crop irrigation, use of natural components that help in arsenic methylation, and biotechnological approaches may explore how to reduce arsenic uptake by food crops. This review will encompass the research advances and practical agronomic strategies on arsenic contamination in rice crop.

106 citations


Cites background from "Westernized diets lower arsenic gas..."

  • ...The acidic pH in the stomach increases arsenic bio-accessibility in comparison to the intestine [127]....

    [...]

  • ...Arsenic undergoes a series of biotransformation in the gastrointestinal tract, including oxidation, reduction, methylation, and thiolation [127]....

    [...]

  • ...Inorganic arsenic species are more likely to bind to the thiol containing amino acid in the endosperm cells of rice seed [127]....

    [...]

Journal ArticleDOI
Hui Duan1, Leilei Yu1, Fengwei Tian1, Qixiao Zhai1, Liuping Fan1, Wei Chen1 
TL;DR: This review is a summary of the bidirectional relationship between HMs and gut microbiota and of the probiotic-based protective strategies against HM-induced gut dysbiosis, with reference to strategies used in the food industry or for medically alleviating HM toxicity.

101 citations

References
More filters
Journal ArticleDOI
TL;DR: Assessment of arsenic levels in paddy soils throughout Bangladesh showed that arsenic levels were elevated in zones where arsenic in groundwater used for irrigation was high, and where these tube-wells have been in operation for the longest period of time.
Abstract: Arsenic contaminated groundwater is used extensively in Bangladesh to irrigate the staple food of the region, paddy rice (Oryza sativa L.). To determine if this irrigation has led to a buildup of arsenic levels in paddy fields, and the consequences for arsenic exposure through rice ingestion, a survey of arsenic levels in paddy soils and rice grain was undertaken. Survey of paddy soils throughout Bangladesh showed that arsenic levels were elevated in zones where arsenic in groundwater used for irrigation was high, and where these tube-wells have been in operation for the longest period of time. Regression of soil arsenic levels with tube-well age was significant. Arsenic levels reached 46 μg g-1 dry weight in the most affected zone, compared to levels below 10 μg g-1 in areas with low levels of arsenic in the groundwater. Arsenic levels in rice grain from an area of Bangladesh with low levels of arsenic in groundwaters and in paddy soils showed that levels were typical of other regions of the world. Model...

938 citations


"Westernized diets lower arsenic gas..." refers background in this paper

  • ...Summarizing the above paragraphs; as rice being one of the major source of arsenic through food and diet components like lipids and fiber affecting the bioaccessibility of ingested arsenic species we aimed to study whether and how bioaccessibility of As is affected by diet composition and further how these diets effect the biotransformations of ingested As. Arsenic through rice is major problem in western countries like America (Trenary et al., 2012) and Eastern countries like Bangladesh, India and Taiwan (Meharg and Rahman, 2003, Chowdhury et al., 2000, Pal et al., 2009), and there is significant difference between diet compositions of these two regions; Asian diet (low in fat, protein and high in carbohydrate) and Western diet (high fat and protein) (Suhana et al., 1999 and Park et al., 2006)....

    [...]

  • ...…through rice is major problem in western countries like America (Trenary et al., 2012) and Eastern countries like Bangladesh, India and Taiwan (Meharg and Rahman, 2003, Chowdhury et al., 2000, Pal et al., 2009), and there is significant difference between diet compositions of these two…...

    [...]

Journal ArticleDOI
TL;DR: A significant dose-response relationship was observed between arsenic level in drinking water and mortality of the cancers, and the multiplicity of inorganic arsenic-induced carcinogenicity without showing any organotropism deserves further investigation.
Abstract: In order to compare risk of various internal organ cancers induced by ingested inorganic arsenic and to assess the differences in risk between males and females, cancer potency indices were calculated using mortality rates among residents in an endemic area of chronic arsenicism on the southwest coast of Taiwan, and the Armitage-Doll multistage model. Based on a total of 898,806 person-years as well as 202 liver cancer, 304 lung cancer, 202 bladder cancer and 64 kidney cancer deaths, a significant dose-response relationship was observed between arsenic level in drinking water and mortality of the cancers. The potency index of developing cancer of the liver, lung, bladder and kidney due to an intake of 10 micrograms kg day of arsenic was estimated as 4.3 x 10(-3), 1.2 x 10(-2), 1.2 x 10(-2), and 4.2 x 10(-3), respectively, for males; as well as 3.6 x 10(-3), 1.3 x 10(-2), 1.7 x 10(-2), and 4.8 x 10(-3), respectively, for females in the study area. The multiplicity of inorganic arsenic-induced carcinogenicity without showing any organotropism deserves further investigation.

750 citations


"Westernized diets lower arsenic gas..." refers background in this paper

  • ...cardiovascular, and neurological effects, have been attributed to As exposure (Chen et al., 1992)....

    [...]

  • ...The major sources of exposure are from food and water. cardiovascular, and neurological effects, have been attributed to As exposure (Chen et al., 1992)....

    [...]

Journal ArticleDOI
TL;DR: Investigation of variation in the assimilation and translocation of arsenic in commercially farmed temperate rice, wheat, and barley found that the risk posed by As in the human food-chain needs to be considered in the context of anaerobic verses aerobic ecosystems.
Abstract: Paired grain, shoot, and soil of 173 individual sample sets of commercially farmed temperate rice, wheat, and barley were surveyed to investigate variation in the assimilation and translocation of arsenic (As). Rice samples were obtained from the Carmargue (France), Donana (Spain), Cadiz (Spain), California, and Arkansas. Wheat and barleywere collected from Cornwall and Devon (England) and the east coast of Scotland. Transfer of As from soil to grain was an order of magnitude greater in rice than for wheat and barley, despite lower rates of shoot-to-grain transfer. Rice grain As levels over 0.60 microg g(-1) d. wt were found in rice grown in paddy soil of around only 10 microg g(-1) As, showing that As in paddy soils is problematic with respect to grain As levels. This is due to the high shoot/soil ratio of approximately 0.8 for rice compared to 0.2 and 0.1 for barley and wheat, respectively. The differences in these transfer ratios are probably due to differences in As speciation and dynamics in anaerobic rice soils compared to aerobic soils for barley and wheat. In rice, the export of As from the shoot to the grain appears to be under tight physiological control as the grain/shoot ratio decreases by more than an order of magnitude (from approximately 0.3 to 0.003 mg/kg) and as As levels in the shoots increase from 1 to 20 mg/kg. A down regulation of shoot-to-grain export may occur in wheat and barley, but it was not detected at the shoot As levels found in this survey. Some agricultural soils in southwestern England had levels in excess of 200 microg g(-1) d. wt, although the grain levels for wheat and barley never breached 0.55 microg g(-1) d. wt. These grain levels were achieved in rice in soils with an order of magnitude lower As. Thus the risk posed by As in the human food-chain needs to be considered in the context of anaerobic verses aerobic ecosystems.

665 citations


"Westernized diets lower arsenic gas..." refers background in this paper

  • ...In a scenario of dietary As exposure, rice has been demonstrated to be one of the major foodstuffs contributing to human As exposure (Williams et al., 2007) and also widely consumed (Raab et al....

    [...]

  • ...In a scenario of dietary As exposure, rice has been demonstrated to be one of the major foodstuffs contributing to human As exposure (Williams et al., 2007) and also widely consumed (Raab et al., 2009)....

    [...]

Journal ArticleDOI
07 Oct 1999-Nature
TL;DR: Observations indicate that arsenic- rich pyrite and other arsenic minerals, which were proposed in previous models to give rise to arsenic pollution, are rare or even absent in the sediments of the Ganges delta.
Abstract: The natural contamination of drinking water by arsenic needs to be urgently addressed. The pollution by naturally occurring arsenic of alluvial Ganges aquifers, which are used for the public water supply in Bangladesh and West Bengal, has been discussed by Nickson et al.1. We agree with their main conclusion that arsenic is released by reductive dissolution of iron oxyhydroxides, as was proposed earlier2. Our observations indicate that arsenic- rich pyrite and other arsenic minerals, which were proposed in previous models (cited by Nickson et al.1) to give rise to arsenic pollution, are rare or even absent in the sediments of the Ganges delta. We believe that arsenic is more likely to be co-precipitated with or scavenged by iron (III) and manganese (IV) in the sedimentary environment.

501 citations

Journal ArticleDOI
TL;DR: In this paper, a method was developed to simulate the human gastrointestinal environment and to estimate bioavailability of arsenic in contaminated soil and solid media, where arsenic was sequentially extracted from contaminated soil with simulated gastric and intestinal solutions.
Abstract: A method was developed to simulate the human gastrointestinal environment and to estimate bioavailability of arsenic in contaminated soil and solid media. In this in vitro gastrointestinal (IVG) method, arsenic is sequentially extracted from contaminated soil with simulated gastric and intestinal solutions. A modified IVG-AB method, where iron hydroxide gel is used to simulate the absorption of arsenic, was also evaluated. Fifteen contaminated soils collected from mining/smelter sites ranging from 401 to 17 460 mg As kg-1 were analyzed. In vitro results were compared with in vivo relative bioavailable arsenic (RBA) determined from dosing trials using immature swine which ranged from 2.7 to 42.8% RBA. Arsenic extracted by the IVG and IVG-AB methods was not statistically different than RBA arsenic measured by the in vivo method. Arsenic extracted by the IVG stomach and intestinal phases was linearly correlated (r = 0.83 and 0.82, respectively) with in vivo arsenic (P < 0.01). Similarly, the IVG-AB method wa...

467 citations


"Westernized diets lower arsenic gas..." refers methods in this paper

  • ...The IVG method was previously validated against in vivo data for As bioaccessibility (Rodriguez and Basta, 1999) in the upper digestive tract (gastric, small intestine), whereas the SHIME has been validated against in vivo data for the colon microbial community composition and metabolic activity toward drugs and phytoestrogens (Molly et al....

    [...]

  • ...The IVG method was previously validated against in vivo data for As bioaccessibility (Rodriguez and Basta, 1999) in the upper digestive tract (gastric, small intestine), whereas the SHIME has been validated against in vivo data for the colon microbial community composition and metabolic activity…...

    [...]