Whispering gallery mode sensors
TL;DR: A comprehensive overview of sensor technology exploiting optical whispering gallery mode (WGM) resonances by detailing the fundamental principles and theory of WGMs in optical microcavities and the transduction mechanisms frequently employed for sensing purposes.
Abstract: We present a comprehensive overview of sensor technology exploiting optical whispering gallery mode (WGM) resonances. After a short introduction we begin by detailing the fundamental principles and theory of WGMs in optical microcavities and the transduction mechanisms frequently employed for sensing purposes. Key recent theoretical contributions to the modeling and analysis of WGM systems are highlighted. Subsequently we review the state of the art of WGM sensors by outlining efforts made to date to improve current detection limits. Proposals in this vein are numerous and range, for example, from plasmonic enhancements and active cavities to hybrid optomechanical sensors, which are already working in the shot noise limited regime. In parallel to furthering WGM sensitivity, efforts to improve the time resolution are beginning to emerge. We therefore summarize the techniques being pursued in this vein. Ultimately WGM sensors aim for real-world applications, such as measurements of force and temperature, or alternatively gas and biosensing. Each such application is thus reviewed in turn, and important achievements are discussed. Finally, we adopt a more forward-looking perspective and discuss the outlook of WGM sensors within both a physical and biological context and consider how they may yet push the detection envelope further.
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TL;DR: The state of the art optical biosensor technologies, including those based on surface plasmon resonance (SPR), optical waveguides, optical resonators, photonic crystals, and optical fibers, are presented.
Abstract: Optical biosensors have exhibited worthwhile performance in detecting biological systems and promoting significant advances in clinical diagnostics, drug discovery, food process control, and environmental monitoring. Without complexity in their pretreatment and probable influence on the nature of target molecules, these biosensors have additional advantages such as high sensitivity, robustness, reliability, and potential to be integrated on a single chip. In this review, the state of the art optical biosensor technologies, including those based on surface plasmon resonance (SPR), optical waveguides, optical resonators, photonic crystals, and optical fibers, are presented. The principles for each type of biosensor are concisely introduced and particular emphasis has been placed on recent achievements. The strengths and weaknesses of each type of biosensor have been outlined as well. Concluding remarks regarding the perspectives of future developments are discussed.
345 citations
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TL;DR: In this paper, the authors focus on optical refractive index (RI) sensors with no fluorescent labeling required, and utilize two parameters to characterize and compare the performance of optical RI sensors: sensitivity to RI change (denoted by symbol SRI) and figure of merit (in short, FoM).
Abstract: DOI: 10.1002/adom.201801433 Scientific American selects plasmonic sensing as the top 10 emerging technologies of 2018.[15] Almost every single new plasmonic or photonic structure would be explored to test its sensing ability.[16–29] These works tend to report the sensing performance of their own structure. Some declare that their sensitivity breaks the world record. However, there is still a missing literature on what the world record really is, the gap between the experiments and the theoretical limit, as well as the differences between metal-based plasmonic sensors and dielectric-based photonic sensors. To push plasmonic and photonic sensors into industrial applications, an optical sensing technology map is absolutely necessary. This review aims to cover a wide range of most representative plasmonic and photonic sensors, and place them into a single map. The sensor performances of different structures will be distinctly illustrated. Future researchers could plot the sensing ability of their new sensors into this technology map and gauge their performances in this field. In this review, we focus on optical refractive index (RI) sensors with no fluorescent labeling required. We will utilize two parameters to characterize and compare the performance of optical RI sensors: sensitivity to RI change (denoted by symbol SRI) and figure of merit (in short, FoM). For simplicity, we restrict our discussions to bulk RI change, where the change in RI occurs within the whole sample. There is another case where the RI variation occurs only within a very small volume close to the sensor surface. This surface RI sensitivity is proportional to the bulk RI sensitivity, the ratio of the thickness of the layer within which the surface RI variation occurs, and the penetration depth of the optical mode.[6] The bulk RI sensitivity defines the ratio of the change in sensor output (e.g., resonance angle, intensity, or resonant wavelength) to the bulk RI variations. Here, we limit our discussions to the spectral interrogations and the bulk RI sensitivity SRI is given by[3,5–7,30]
259 citations
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TL;DR: This review focuses on single nanoparticle detection using optical whispering gallery microcavities and photonic crystal microc Cavities, both of which have been developing rapidly over the past few years.
Abstract: Detection of nanoscale objects is highly desirable in various fields such as early-stage disease diagnosis, environmental monitoring and homeland security. Optical microcavity sensors are renowned for ultrahigh sensitivities due to strongly enhanced light-matter interaction. This review focuses on single nanoparticle detection using optical whispering gallery microcavities and photonic crystal microcavities, both of which have been developing rapidly over the past few years. The reactive and dissipative sensing methods, characterized by light-analyte interactions, are explained explicitly. The sensitivity and the detection limit are essentially determined by the cavity properties, and are limited by the various noise sources in the measurements. On the one hand, recent advances include significant sensitivity enhancement using techniques to construct novel microcavity structures with reduced mode volumes, to localize the mode field, or to introduce optical gain. On the other hand, researchers attempt to lower the detection limit by improving the spectral resolution, which can be implemented by suppressing the experimental noises. We also review the methods of achieving a better temporal resolution by employing mode locking techniques or cavity ring up spectroscopy. In conclusion, outlooks on the possible ways to implement microcavity-based sensing devices and potential applications are provided.
250 citations
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TL;DR: Optical Whispering Gallery Modes (WGMs) derive their name from a famous acoustic phenomenon of guiding a wave by a curved boundary observed nearly a century ago as mentioned in this paper, which enables resonators of unique properties attractive both in science and engineering.
Abstract: Optical Whispering Gallery Modes (WGMs) derive their name from a famous acoustic phenomenon of guiding a wave by a curved boundary observed nearly a century ago. This phenomenon has a rather general nature, equally applicable to sound and all other waves. It enables resonators of unique properties attractive both in science and engineering. Very high quality factors of optical WGM resonators persisting in a wide wavelength range spanning from radio frequencies to ultraviolet light, their small mode volume, and tunable in- and out- coupling make them exceptionally efficient for nonlinear optical applications. Nonlinear optics facilitates interaction of photons with each other and with other physical systems, and is of prime importance in quantum optics. In this paper we review numerous applications of WGM resonators in nonlinear and quantum optics. We outline the current areas of interest, summarize progress, highlight difficulties, and discuss possible future development trends in these areas.
231 citations
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TL;DR: Using numerical simulations, it is demonstrated that, by solely exploiting a proper geometrical arrangement and WGM resonances in a TiO2 sphere, the plasmonic absorption can be extended over the entire visible range and can be increased by more than 40 times.
Abstract: Recently, surface plasmon resonance (SPR) effects have been widely used to construct photocatalysts which are active in the visible spectral region. Such plasmonic photocatalysts usually comprise a semiconductor material transparent in the visible range (such as TiO2) and plasmonic nano-objects (e.g., Au nanoparticles (Au NPs)). Specific SPRs, though, only partially cover the visible spectrum and feature weak light absorption. Here, we explore the unique role played by whispering gallery mode (WGM) resonances in the expression of the photocatalytic activity of plasmonic photocatalysts. Using numerical simulations, we demonstrate that, by solely exploiting a proper geometrical arrangement and WGM resonances in a TiO2 sphere, the plasmonic absorption can be extended over the entire visible range and can be increased by more than 40 times. Furthermore, the local electric field at the Au–TiO2 interface is also considerably enhanced. These results are experimentally corroborated, by means of absorption spectro...
220 citations
References
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01 Jan 1983
TL;DR: In this paper, a Potpourri of Particles is used to describe surface modes in small Particles and the Angular Dependence of Scattering is shown to be a function of the size of the particles.
Abstract: BASIC THEORY. Electromagnetic Theory. Absorption and Scattering by an Arbitrary Particle. Absorption and Scattering by a Sphere. Particles Small Compared with the Wavelength. Rayleigh--Gans Theory. Geometrical Optics. A Potpourri of Particles. OPTICAL PROPERTIES OF BULK MATTER. Classical Theories of Optical Constants. Measured Optical Properties. OPTICAL PROPERTIES OF PARTICLES. Extinction. Surface Modes in Small Particles. Angular Dependence of Scattering. A Miscellany of Applications. Appendices. References. Index.
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TL;DR: In this article, the authors describe a new and highly effective optical frequency discriminator and laser stabilization system based on signals reflected from a stable Fabry-Perot reference interferometer.
Abstract: We describe a new and highly effective optical frequency discriminator and laser stabilization system based on signals reflected from a stable Fabry-Perot reference interferometer. High sensitivity for detection of resonance information is achieved by optical heterodyne detection with sidebands produced by rf phase modulation. Physical, optical, and electronic aspects of this discriminator/laser frequency stabilization system are considered in detail. We show that a high-speed domain exists in which the system responds to the phase (rather than frequency) change of the laser; thus with suitable design the servo loop bandwidth is not limited by the cavity response time. We report diagnostic experiments in which a dye laser and gas laser were independently locked to one stable cavity. Because of the precautions employed, the observed sub-100 Hz beat line width shows that the lasers were this stable. Applications of this system of laser stabilization include precision laser spectroscopy and interferometric gravity-wave detectors.
3,393 citations
"Whispering gallery mode sensors" refers methods in this paper
...In the Pound–Drever–Hall (PDH) method [199] an electronic feedback loop is implemented to lock the laser frequency to the WGM resonance....
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...A WGM sensor based on monitoring WGM resonance shifts and operating with a shot noise limited resolution, for example, has a limit of detection given by [199]...
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TL;DR: Single-molecule, real-time sequencing data obtained from a DNA polymerase performing uninterrupted template-directed synthesis using four distinguishable fluorescently labeled deoxyribonucleoside triphosphates (dNTPs) are presented.
Abstract: We present single-molecule, real-time sequencing data obtained from a DNA polymerase performing uninterrupted template-directed synthesis using four distinguishable fluorescently labeled deoxyribonucleoside triphosphates (dNTPs). We detected the temporal order of their enzymatic incorporation into a growing DNA strand with zero-mode waveguide nanostructure arrays, which provide optical observation volume confinement and enable parallel, simultaneous detection of thousands of single-molecule sequencing reactions. Conjugation of fluorophores to the terminal phosphate moiety of the dNTPs allows continuous observation of DNA synthesis over thousands of bases without steric hindrance. The data report directly on polymerase dynamics, revealing distinct polymerization states and pause sites corresponding to DNA secondary structure. Sequence data were aligned with the known reference sequence to assay biophysical parameters of polymerization for each template position. Consensus sequences were generated from the single-molecule reads at 15-fold coverage, showing a median accuracy of 99.3%, with no systematic error beyond fluorophore-dependent error rates.
3,346 citations