White matter damage in primary progressive aphasias: a diffusion tensor tractography study
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633 citations
Cites background from "White matter damage in primary prog..."
...…uncinate fasciculus and semantic dementia (Matsuo et al., 2008; Agosta et al., 2010; Whitwell et al., 2010; Acosta-Cabronero et al., 2011; Galantucci et al., 2011) with a smaller number reporting changes in both the left and right uncinate fasciculus (Matsuo et al., 2008; Galantucci et al., 2011)....
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...Also the uncinate fasciculus is not implicated in primary progressive aphasia (Galantucci et al., 2011)....
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...One study reported that patients with semantic dementia had lower fractional anisotropy values in bilateral uncinate fasciculus compared with both non-fluent aphasics, who exhibit agrammaticism and motor speech errors, and healthy control subjects, suggesting that the uncinate fasciculus is particularly associated with semantic retrieval rather than speech output (Galantucci et al., 2011)....
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..., 2011) with a smaller number reporting changes in both the left and right uncinate fasciculus (Matsuo et al., 2008; Galantucci et al., 2011)....
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...…the left uncinate fasciculus and semantic dementia (Matsuo et al., 2008; Agosta et al., 2010; Whitwell et al., 2010; Acosta-Cabronero et al., 2011; Galantucci et al., 2011) with a smaller number reporting changes in both the left and right uncinate fasciculus (Matsuo et al., 2008; Galantucci et…...
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426 citations
402 citations
Cites background from "White matter damage in primary prog..."
...In support of a semantic function, reduction in fractional anisotropy (indicative of white matter damage) in the uncinate fasciculus is related to the semantic variant subtype of primary progressive aphasia (Gorno-Tempini et al., 2004; Agosta et al., 2011; Galantucci et al., 2011)....
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378 citations
Cites background or methods from "White matter damage in primary prog..."
...…the left arcuate fasciculus has been associated with deficits in comprehension and production of gram- mar (Wilson et al., 2011), whereas more ventral tracts (e.g. un- cinate fasciculus) are greatly damaged in patients with PPA with semantic deficits (Agosta et al., 2010; Galantucci et al., 2011)....
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...This hypothesis has been recently tested with diffusion tensor imaging (DTI) tractography (Agosta et al., 2010; Galantucci et al., 2011; Wilson et al., 2011)....
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...BRAIN...
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...…particular tractography has been used to probe the micro- structural properties of white matter along specific tracts and to identify correlations between tract-specific degeneration and lan- guage deficit severity (Wilson et al., 2011) or with specific sub- types of PPA (Galantucci et al., 2011)....
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293 citations
References
6,999 citations
"White matter damage in primary prog..." refers methods in this paper
...…reports, a voxel-based morphometry analysis was performed using the SPM5 software package (http://www.fil.ion.ucl.ac.uk/spm) (Ashburner and Friston, 2005) and a diffeomorphic exponentiated lie algebra (DARTEL) registration method (Ashburner, 2007), as previously described by Wilson et al. (2009)....
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...uk/spm) (Ashburner and Friston, 2005) and a diffeomorphic exponentiated lie algebra (DARTEL) registration method (Ashburner, 2007), as previously described by Wilson et al....
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5,641 citations
"White matter damage in primary prog..." refers background or methods in this paper
...This phenomenon is called water-diffusion anisotropy (or directionality) and can be represented by the diffusion tensor model (Basser et al., 1994; Hagmann et al., 2006; Assaf and Pasternak, 2008; Yamada et al., 2009)....
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...Fractional anisotropy was calculated from the standard deviation of the three eigenvalues ranging from 0 to 1 (Basser et al., 1994)....
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...provide a mean diffusivity and can be used to compute the fractional anisotropy, which is a scalar value that describes the shape of the diffusion tensor and ranges from 0 to 1 (Basser et al., 1994)....
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...These parameters can be averaged to provide a mean diffusivity and can be used to compute the fractional anisotropy, which is a scalar value that describes the shape of the diffusion tensor and ranges from 0 to 1 (Basser et al., 1994)....
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4,708 citations
"White matter damage in primary prog..." refers background in this paper
...Three main clin- ical variants of primary progressive aphasia have been described depending on which parts of this network have the greatest damage: (i) non-fluent/agrammatic primary progressive aphasia (previously called progressive non-fluent aphasia) is characterized by agrammatism, motor speech errors and left inferior frontal damage; (ii) semantic variant primary progressive aphasia (previ- ously called semantic dementia) is characterized by single-word comprehension and retrieval deficits, loss of semantic knowledge, surface dyslexia and anterior temporal atrophy; and (iii) the logo- penic variant primary progressive aphasia (previously called logo- penic progressive aphasia) is characterized by word-finding deficits, phonological errors in spontaneous speech and naming, sentence repetition impairment and left posterior temporal and inferior parietal damage (Hodges and Patterson, 1996; Neary et al., 1998; Gorno-Tempini et al., 2004, 2008; Mesulam et al., 2009; Rabinovici and Miller, 2010; Henry and Gorno-Tempini, 2010)....
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...…errors in spontaneous speech and naming, sentence repetition impairment and left posterior temporal and inferior parietal damage (Hodges and Patterson, 1996; Neary et al., 1998; Gorno-Tempini et al., 2004, 2008; Mesulam et al., 2009; Rabinovici and Miller, 2010; Henry and Gorno-Tempini, 2010)....
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4,216 citations
"White matter damage in primary prog..." refers background in this paper
...Furthermore, other conditions such as glial alterations, increased membrane permeability and diffusivity, destruction of intracellular structures, alterations in the cytoskeleton and axonal transport, could influence different DTI metrics in ways that are not well understood (Beaulieu, 2002; Song et al., 2002)....
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...Specifically, alterations of axial diffusivity suggest axonal damage and alter- ations of radial diffusivity suggest myelin damage (Beaulieu, 2002; Song et al., 2002), although this remains controversial (Wheeler-Kingshott and Cercignani, 2009)....
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...However, other situations, such as fibre reorgan- ization, could occur in neurodegenerative disease resulting in a decrease in fractional anisotropy, but via a different mechanism, such as a reduction in axial diffusivity with an increase of radial diffusivity (Beaulieu, 2002; Song et al., 2002)....
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...Specifically, alterations of axial diffusivity suggest axonal damage and alterations of radial diffusivity suggest myelin damage (Beaulieu, 2002; Song et al., 2002), although this remains controversial (Wheeler-Kingshott and Cercignani, 2009)....
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...However, other situations, such as fibre reorganization, could occur in neurodegenerative disease resulting in a decrease in fractional anisotropy, but via a different mechanism, such as a reduction in axial diffusivity with an increase of radial diffusivity (Beaulieu, 2002; Song et al., 2002)....
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3,635 citations
"White matter damage in primary prog..." refers background in this paper
...Patients were then diagnosed with a particular primary progressive aphasia variant based on diagnostic classification recently developed by an international group of primary progressive aphasia researchers (Gorno-Tempini et al., 2011)....
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