WHO Treatment Guidelines for Drug-Resistant Tuberculosis, 2016 Update: Applicability in South Korea.
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TLDR
Key changes include the introduction of a new, shorter MDR-TB treatment regimen, a new classification of medicines and updated recommendations for the conventional MDR -TB regimen.Abstract:
Despite progress made in tuberculosis control worldwide, the disease burden and treatment outcome of multidrug-resistant tuberculosis (MDR-TB) patients have remained virtually unchanged. In 2016, the World Health Organization released new guidelines for the management of MDR-TB. The guidelines are intended to improve detection rate and treatment outcome for MDR-TB through novel, rapid molecular testing and shorter treatment regimens. Key changes include the introduction of a new, shorter MDR-TB treatment regimen, a new classification of medicines and updated recommendations for the conventional MDR-TB regimen. This paper will review these key changes and discuss the potential issues with regard to the implementation of these guidelines in South Korea.read more
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References
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WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update
Dennis Falzon,Ernesto Jaramillo,Holger J. Schünemann,Matthew Arentz,Melissa Bauer,Jaime Bayona,Léopold Blanc,Jose A. Caminero,Charles L. Daley,Chris Duncombe,Christopher Fitzpatrick,Agnes Gebhard,Haileyesus Getahun,Myriam Henkens,Timothy H. Holtz,J. Keravec,S. Keshavjee,Aamir J. Khan,R. Kulier,Vaira Leimane,Christian Lienhardt,Chunling Lu,Mar'iandyshev Ao,Giovanni Battista Migliori,Fuad Mirzayev,Carole D. Mitnick,Paul Nunn,G. Nwagboniwe,Olivia Oxlade,Domingo Palmero,Patricia B Pavlinac,M. I. D. Quelapio,Mario C. Raviglione,Michael Rich,S. Royce,Sabine Rüsch-Gerdes,A. Salakaia,R. Sarin,Delphine Sculier,Francis Varaine,Marco Vitoria,Judd L. Walson,Fraser Wares,Karin Weyer,Richard A. White,Matteo Zignol +45 more
TL;DR: The guidelines promote the early use of antiretroviral agents for TB patients with HIV on second-line drug regimens and systems that primarily employ ambulatory models of care are recommended over others based mainly on hospitalisation.
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Short, highly effective, and inexpensive standardized treatment of multidrug-resistant tuberculosis.
Armand Van Deun,Aung Kya Jai Maug,Salim Ah,Pankaj Kumar Das,Mihir Ranjan Sarker,Paul Daru,Hans L. Rieder +6 more
TL;DR: Serial regimen formulation guided by overall treatment effectiveness resulted in treatment outcomes comparable to those obtained with first-line treatment, including a relapse-free cure among 206 patients.
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Multidrug Resistant Pulmonary Tuberculosis Treatment Regimens and Patient Outcomes: An Individual Patient Data Meta-analysis of 9,153 Patients
Shama D. Ahuja,David Ashkin,Monika Avendano,Rita Banerjee,Melissa Bauer,Jamie N. Bayona,Mercedes C. Becerra,Mercedes C. Becerra,Andrea Benedetti,Marcos Burgos,Rosella Centis,Eward D. Chan,Chen Yuan Chiang,Helen Cox,Lia D'Ambrosio,Kathy DeRiemer,Nguyen Huy Dung,Donald A. Enarson,Dennis Falzon,Katherine Flanagan,Jennifer Flood,Maria de Lourdes García-García,Neel R. Gandhi,Reuben Granich,Maria G. Hollm-Delgado,Timothy H. Holtz,Michael D. Iseman,Leah G. Jarlsberg,Salmaan Keshavjee,Hye-Ryoun Kim,Won-Jung Koh,Joey Lancaster,Christophe Lange,Wiel C M de Lange,Vaira Leimane,Chi Chiu Leung,Jiehui Li,Dick Menzies,Giovanni Battista Migliori,Sergey P. Mishustin,Carole D. Mitnick,Masa Narita,Philly O'Riordan,Madhukar Pai,Domingo Palmero,Seung-kyu Park,Geoffrey Pasvol,José María Peña,Carlos Pérez-Guzmán,M. I. D. Quelapio,Alfredo Ponce-de-León,Vija Riekstina,Jérôme Robert,Sarah Royce,H. Simon Schaaf,Kwonjune J. Seung,Lena Shah,Tae Sun Shim,Sonya Shin,Yuji Shiraishi,José Sifuentes-Osornio,Giovanni Sotgiu,Matthew Strand,Payam Tabarsi,Thelma E. Tupasi,Robert van Altena,Martie van der Walt,Tjip S. van der Werf,Mario H. Vargas,Pirett Viiklepp,Janice Westenhouse,Wing Wai Yew,Jae-Joon Yim +72 more
TL;DR: Findings from a collaborative, individual patient-level meta-analysis of treatment outcomes among patients with multidrug-resistant tuberculosis are reported.
Journal ArticleDOI
Linezolid for Treatment of Chronic Extensively Drug-Resistant Tuberculosis
Myungsun Lee,Jongmin Lee,Matthew W. Carroll,Hongjo Choi,Seonyeong Min,Taeksun Song,Laura E. Via,Lisa C. Goldfeder,Eunhwa Kang,Boyoung Jin,Hyeeun Park,Hyun-Kyung Kwak,Hyun-Chul Kim,Han Seung Jeon,Ina Jeong,Joon Sung Joh,Ray Y. Chen,Kenneth N. Olivier,Pamela A. Shaw,Dean Follmann,Sun Dae Song,Jong Koo Lee,Duk-Hyoung Lee,Cheon Tae Kim,Véronique Dartois,Seung-kyu Park,Sang Nae Cho,Clifton E. Barry +27 more
TL;DR: Linezolid is effective at achieving culture conversion among patients with treatment-refractory XDR pulmonary tuberculosis, but patients must be monitored carefully for adverse events.
Linezolid for treatment of chronic extensively drug-resistant tuberculosis
Myungsun Lee,Jongmin Lee,Matthew W. Carroll,Hongjo Choi,Seonyeong Min,Taeksun Song,Laura E. Via,Lisa C. Goldfeder,Eunhwa Kang,Boyoung Jin,Hyeeun Park,Hyun-Kyung Kwak,Hyun-Chul Kim,Han Seung Jeon,Ina Jeong,Joon Sung Joh,Ray Y. Chen,Kenneth N. Olivier,Pamela A. Shaw,Dean Follmann,Sun Dae Song,Jong Koo Lee,Duk-Hyoung Lee,Cheon Tae Kim,Véronique Dartois,Seung-kyu Park,Sang Nae Cho,Clifton E. Barry +27 more
TL;DR: In this article, the authors reported that linezolid is effective at achieving culture conversion among patients with treatment-resistant XDR pulmonary tuberculosis, but patients must be monitored carefully for adverse events.