Whole-Genome Comparative Analysis of Two Carbapenem-Resistant ST-258 Klebsiella pneumoniae Strains Isolated during a North-Eastern Ohio Outbreak: Differences within the High Heterogeneity Zones.
Maria Soledad Ramirez,Gang Xie,German Matias Traglia,Shannon L. Johnson,Karen W. Davenport,David van Duin,Azam Ramazani,Azam Ramazani,Federico Perez,Michael R. Jacobs,David J. Sherratt,Robert A. Bonomo,Robert A. Bonomo,Patrick S.G. Chain,Marcelo E. Tolmasky +14 more
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TLDR
The potential value of the high heterogeneity zone (HHZ) as a potential marker for K. pneumoniae clinical and epidemiological studies is identified.Abstract:
Klebsiella pneumoniae has become one of the most dangerous causative agents of hospital infections due to the acquisition of resistance to carbapenems, one of the last resort families of antibiotics. Resistance is usually mediated by carbapenemases coded for by different classes of genes. A prolonged outbreak of carbapenem-resistant K. pneumoniae infections has been recently described in northeastern Ohio. Most strains isolated from patients during this outbreak belong to MLST sequence type 258 (ST258). To understand more about this outbreak two isolates (strains 140 and 677), one of them responsible for a fatal infection, were selected for genome comparison analyses. Whole genome map and sequence comparisons demonstrated that both strains are highly related showing 99% average nucleotide identity. However, the genomes differ at the so-called high heterogeneity zone (HHZ) and other minor regions. This study identifies the potential value of the HHZ as a potential marker for K. pneumoniae clinical and epidemiological studies.read more
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疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
Carbapenemases: Transforming Acinetobacter baumannii into a Yet More Dangerous Menace.
TL;DR: The enzymes within the OXA, NDM, VIM, IMP, and KPC groups of carbapenemases and the coding genes found in A. baumannii clinical isolates are described.
Journal ArticleDOI
Unconventional Roles of Opsins
Nicole Y. Leung,Craig Montell +1 more
TL;DR: The findings in Drosophila suggest that opsins have light-independent roles, countering more than a century of dogma that they function exclusively as light sensors.
Journal ArticleDOI
The genome of Nautilus pompilius illuminates eye evolution and biomineralization.
Yang Zhang,Fan Mao,Huawei Mu,Minwei Huang,Yongbo Bao,Lili Wang,Nai-Kei Wong,Shu Xiao,He Dai,Zhiming Xiang,Mingli Ma,Yuanyan Xiong,Ziwei Zhang,Lvping Zhang,Xiaoyuan Song,Fan Wang,Xiyu Mu,Jun Li,Haitao Ma,Yuehuan Zhang,Hongkun Zheng,Oleg Simakov,Ziniu Yu +22 more
TL;DR: A complete Nautilus pompilius genome is presented as a fundamental genomic reference on cephalopod innovations, such as the pinhole eye and biomineralization, and shows a compact, minimalist genome with few encoding genes and slow evolutionary rates.
Journal ArticleDOI
The nervous and visual systems of onychophorans and tardigrades: learning about arthropod evolution from their closest relatives.
Christine Martin,Vladimir Gross,Lars Hering,Benjamin Tepper,Henry Jahn,Ivo de Sena Oliveira,Ivo de Sena Oliveira,Paul A. Stevenson,Georg Mayer +8 more
TL;DR: This review summarises current knowledge of the evolution of panarthropod nervous and visual systems and addresses some of the many controversies surrounding these topics, such as the homology of the onychophoran eyes to those of arthropods as well as the segmentation of the tardigrade brain.
References
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疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence.
Todd M. Lowe,Sean R. Eddy +1 more
TL;DR: A program is described, tRNAscan-SE, which identifies 99-100% of transfer RNA genes in DNA sequence while giving less than one false positive per 15 gigabases.
Journal ArticleDOI
The RAST Server: Rapid Annotations using Subsystems Technology
Ramy K. Aziz,Ramy K. Aziz,Daniela Bartels,Aaron A. Best,Matthew DeJongh,Terrence Disz,Terrence Disz,Robert Edwards,Kevin Formsma,Svetlana Gerdes,Elizabeth M. Glass,Michael Kubal,Folker Meyer,Folker Meyer,Gary J. Olsen,Gary J. Olsen,Robert Olson,Robert Olson,Andrei L. Osterman,Ross Overbeek,Leslie Klis McNeil,Daniel Paarmann,Tobias Paczian,Bruce Parrello,Gordon D. Pusch,Claudia I. Reich,Rick Stevens,Rick Stevens,Olga Vassieva,Veronika Vonstein,Andreas Wilke,Olga Zagnitko +31 more
TL;DR: A fully automated service for annotating bacterial and archaeal genomes that identifies protein-encoding, rRNA and tRNA genes, assigns functions to the genes, predicts which subsystems are represented in the genome, uses this information to reconstruct the metabolic network and makes the output easily downloadable for the user.