Journal ArticleDOI
Why is glaucoma associated with exfoliation syndrome
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TLDR
Exfoliation syndrome is an age-related, generalized disorder of the extracellular matrix characterized by production and progressive accumulation of a fibrillar material in tissues throughout the anterior segment and also in connective tissue portions of various visceral organs.About:
This article is published in Progress in Retinal and Eye Research.The article was published on 2003-05-01. It has received 218 citations till now. The article focuses on the topics: Glaucoma & Trabecular meshwork.read more
Citations
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Journal ArticleDOI
Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma.
Gudmar Thorleifsson,Kristinn P. Magnusson,Patrick Sulem,G. Bragi Walters,Daniel F. Gudbjartsson,Hreinn Stefansson,Thorlakur Jonsson,Adalbjorg Jonasdottir,Aslaug Jonasdottir,Gerdur Stefansdottir,Gisli Masson,Gudmundur A. Hardarson,H. Petursson,Arsaell Arnarsson,Mehdi Motallebipour,Ola Wallerman,Claes Wadelius,Jeffrey R. Gulcher,Unnur Thorsteinsdottir,Augustine Kong,Fridbert Jonasson,Kari Stefansson +21 more
TL;DR: Two nonsynonymous SNPs in exon 1 of the gene LOXL1 explain the association with glaucoma, and the data suggest that they confer risk of XFG mainly through exfoliation syndrome (XFS).
Journal ArticleDOI
The role of TGF-β in the pathogenesis of primary open-angle glaucoma.
Rudolf Fuchshofer,Ernst R. Tamm +1 more
TL;DR: The available data strongly indicate that TGF-β2 is a key player contributing to the structural changes in the extracellular matrix (ECM) of the trabecular meshwork and optic nerve head as characteristically seen in POAG.
Journal ArticleDOI
European Glaucoma Society Terminology and Guidelines for Glaucoma, 4th Edition - Chapter 2: Classification and terminologySupported by the EGS Foundation: Part 1: Foreword; Introduction; Glossary; Chapter 2 Classification and Terminology
Tavistock Square,London,Wc H +2 more
TL;DR: Primary congenital glaucoma is a rare disease but has a major impact on the child’s development and quality of life over his/her whole life span and early diagnosis and appropriate therapy can make a huge difference in the visual outcome and can prevent lifelong disability.
Journal ArticleDOI
Oxidative and nitrative stress markers in glaucoma
TL;DR: It is concluded that oxidative and nitrative stress have a pathogenic role in glaucoma and the relevance of antioxidants in neurodegeneration associated with the disease is examined.
Journal ArticleDOI
Clinical results of ab interno trabeculotomy using the trabectome for open-angle glaucoma: the Mayo Clinic series in Rochester, Minnesota.
TL;DR: For criteria involving IOP ≤18 mm Hg, the 24-month survival of ab interno trabeculotomy is low and this surgery is appropriate for patients requiring a target IOP of 21mm Hg or above.
References
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Journal ArticleDOI
Trabecular meshwork cellularity in primary open-angle glaucoma and nonglaucomatous normals.
TL;DR: The results show that the trabecular cellularity in NG specimens decreases most rapidly and in a nonlinear manner in the late fetal period and for the first few years of postnatal life, and this rapid decline in cellularity then slows down to proceed in a nearly linear manner for the remainder of the 98 years of life studied.
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Aqueous Humor in Glaucomatous Eyes Contains an Increased Level of TGF-β2
TL;DR: The present findings support the concept of the intraocular derivation of this cytokine and hypothesize that the increased level of TGF-β2 in the aqueous humor of POAG patients causes a decrease in the cellularity of the trabecular meshwork and promotes the buildup of excessive amounts of ECM materials that are characteristic of this disease and contribute to the increased resistance to aQueous outflow.
Journal ArticleDOI
Pseudoexfoliation syndrome, ocular manifestation of a systemic disorder?
TL;DR: Findings provide evidence for the systemic nature of the pseudoexfoliation syndrome, which apparently involves an aberrant connective-tissue metabolism throughout the body.
Journal ArticleDOI
Pseudoexfoliation syndrome for the comprehensive ophthalmologist. Intraocular and systemic manifestations.
TL;DR: In view of the multitude of clinical complications, PEX is of relevance to comprehensive ophthalmologists, including specialists in glaucoma, cataract, cornea, neuro-ophthalmology, and retina.
Related Papers (5)
Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma.
Gudmar Thorleifsson,Kristinn P. Magnusson,Patrick Sulem,G. Bragi Walters,Daniel F. Gudbjartsson,Hreinn Stefansson,Thorlakur Jonsson,Adalbjorg Jonasdottir,Aslaug Jonasdottir,Gerdur Stefansdottir,Gisli Masson,Gudmundur A. Hardarson,H. Petursson,Arsaell Arnarsson,Mehdi Motallebipour,Ola Wallerman,Claes Wadelius,Jeffrey R. Gulcher,Unnur Thorsteinsdottir,Augustine Kong,Fridbert Jonasson,Kari Stefansson +21 more