Within-subject, double-blinded, randomized, and placebo-controlled evaluation of the combined effects of the cannabinoid dronabinol and the opioid hydromorphone in a human laboratory pain model.
Kelly E. Dunn,Cecilia L. Bergeria,Andrew S. Huhn,Traci J. Speed,Chung Jung Mun,Ryan Vandrey,Claudia M. Campbell +6 more
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In this paper, the authors evaluated the effect of delta-9-tetrahydrocannabinol (THC; dronabinol) on hydromorphone-based analgesia, abuse liability, and cognitive performance.About:
This article is published in Neuropsychopharmacology.The article was published on 2021-04-20 and is currently open access. It has received 11 citations till now. The article focuses on the topics: Hydromorphone & Dronabinol.read more
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Opioid-sparing effect of cannabinoids for analgesia: an updated systematic review and meta-analysis of preclinical and clinical studies
Suzanne Nielsen,Louisa Picco,Bridin Murnion,Bryony L. Winters,Justin Matheson,Myfanwy Graham,Gabrielle Campbell,Laila Parvaresh,Kok Eng Khor,Brigid Betz-Stablein,Michael Farrell,Nicholas Lintzeris,Bernard Le Foll +12 more
TL;DR: A recent systematic review on the opioid-sparing effects of cannabinoids considered preclinical and clinical studies where the outcome was analgesia or opioid dose requirements as mentioned in this paper , found that the median effective dose (ED 50 ) administered with delta-9-tetrahydrocannabinol was 3.5 times lower (95% CI 2.04, 6.03) than the ED 50 of morphine alone.
Journal ArticleDOI
Medicinal Cannabis and Central Nervous System Disorders
TL;DR: This review will examine both preclinical and clinical evidence that supports or refutes the therapeutic utility of medicinal cannabis for the treatment of pathological pain, neurodegeneration, substance use disorders, as well as anxiety-related disorders.
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Cannabinoid 1 and mu-Opioid Receptor Agonists Synergistically Inhibit Abdominal Pain and Lack Side Effects in Mice.
TL;DR: In this paper , the authors investigated whether cannabinoids inhibit mouse colonic nociception, alone or in combination with opioids at low doses, and found that CB1R agonists may enable opioid dose reduction and avoid opioid-related side effects.
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No antinociceptive synergy between morphine and delta-9-tetrahydrocannabinol in male and female rats with persistent inflammatory pain.
TL;DR: In this paper, the effects of delta-9-tetrahydrocannabinol (THC) and morphine (s.c., 3.1, 3:1 and 1:3 dose ratios) were evaluated in rats with persistent inflammatory pain.
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Do We Have Structure, Process and Outcomes to Support Cannabis as Supportive Therapy in Cancer?
TL;DR: The structure of cannabis distribution, the process of acquisition, outcomes, and the safety of cannabis in the United States are explored.
References
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Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Standardized protocol and reference values
Roman Rolke,Ralf Baron,Christoph Maier,Thomas R. Tölle,Rolf-Detlef Treede,Antje Beyer,Andreas Binder,Niels Birbaumer,Frank Birklein,I. C. Bötefür,S. Braune,Herta Flor,Volker Huge,R. Klug,G. B. Landwehrmeyer,Walter Magerl,Christian Maihöfner,C. Rolko,C. Schaub,Andrea Scherens,Till Sprenger,Michael Valet,B. Wasserka +22 more
TL;DR: Application of this standardized QST protocol in patients and human surrogate models will allow to infer underlying mechanisms from somatosensory phenotypes as well as judge plus or minus signs in patients.
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Peripheral and central mechanisms of cutaneous hyperalgesia.
TL;DR: In the literature, there are some contradictions with respect to the stimulus modalities to which hyperalgesia and sensitization occur and this contradiction should spawn further investigations into the mechanical response properties of nociceptors and into the molecular mechanisms of heat sensitization.
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Characteristics of Initial Prescription Episodes and Likelihood of Long-Term Opioid Use — United States, 2006–2015
TL;DR: In this paper, patient records from the IMS Lifelink+ database were analyzed to characterize the first episode of opioid use among commercially insured, opioid-naive, cancer-free adults and quantify the increase in probability of long-term use of opioids with each additional day supplied, day of therapy, or incremental increase in cumulative dose.
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Medical Cannabis Laws and Opioid Analgesic Overdose Mortality in the United States, 1999-2010
TL;DR: Examination of the association between medical cannabis laws and opioid analgesic overdose mortality in each year after implementation of the law showed that such laws were associated with a lower rate of overdose mortality that generally strengthened over time.
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Adjust for Multiple Comparisons? It’s Not That Simple
TL;DR: In confirmatory studies, which may lead to a change in clinical practice or approval of a new treatment, it is more important to guard against the possibility of false-positive results, while in exploratory studies or post-hoc analysis of existing data, a strict adjustment for multiple comparisons is less critical.