Wnt addiction of genetically defined cancers reversed by PORCN inhibition
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...In promising experiments, some of these drugs have been shown to inhibit the growth of transplanted or even autochthonous tumors in mousemodels (Madan et al., 2016; Tammela et al., 2017) and a clinical trial for the Porcupine inhibitor LGK974, in patients with several forms of cancer, is ongoing (https://clinicaltrials....
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...In promising experiments, some of these drugs have been shown to inhibit the growth of transplanted or even autochthonous tumors in mousemodels (Madan et al., 2016; Tammela et al., 2017) and a clinical trial for the Porcupine inhibitor LGK974, in patients with several forms of cancer, is ongoing…...
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