WNT/β-catenin Pathway Activation Correlates with Immune Exclusion across Human Cancers
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...This correlation between CTNNB1 mutation and T-cell exclusion has been validated across a large set of human cancers (50)....
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"WNT/β-catenin Pathway Activation Co..." refers background in this paper
...In melanoma, anti-cytotoxic T lymphocyte antigen 4 (CTLA-4) and anti-programmed death 1 (PD-1) antibodies have demonstrated robust response rates with years of durability in some patients (1, 2) and improvement in overall survival (3, 4)....
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"WNT/β-catenin Pathway Activation Co..." refers background in this paper
...Solid tumor histologies can be segregated based on the degree of the T-cell-inflamed tumor microenvironment gene expression signature Strong associations have been observed between the presence of T-cell-infiltration and/or a T-cell-inflamed gene expression signature and response to immune-checkpoint blockade (10, 21)....
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