Wnt/Ca2+ signaling pathway: a brief overview
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...For example, although membrane-bound Wnt3 ligands retain a short range, but high level of Wnt signaling in intestinal organoids,30,31 exosome-bound Wnt2b in the 1German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, Heidelberg University, Department Cell and Molecular Biology, Faculty of Medicine Mannheim, Heidelberg, Germany; 2Heidelberg University, Department of Internal Medicine II, Medical Faculty Mannheim, Mannheim, Germany and 3German Cancer Consortium (DKTK), Heidelberg, Germany....
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...German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, Heidelberg University, Department Cell and Molecular Biology, Faculty of Medicine Mannheim, Heidelberg, Germany; (2)Heidelberg University, Department of Internal Medicine II, Medical Faculty Mannheim, Mannheim, Germany and (3)German Cancer Consortium (DKTK), Heidelberg, Germany. Correspondence: Professor M Boutros, German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, Im Neuenheimer Feld 580, Heidelberg, Germany. E-mail: m.boutros@dkfz.de (4)These authors contributed equally to this work. Received 29 May 2016; revised 7 July 2016; accepted 17 July 2016; published online 12 September 2016 Oncogene (2017) 36, 1461–1473...
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...…downstream mediators, such as protein kinase C, calcineurin and calcium calmodulin-dependent protein kinase II, which in turn activate transcription factors, such as nuclear factor κB, nuclear factor of activated T cells and cAMP response element binding protein [De, 2011; Rao and Kühl, 2010]....
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...The released calcium activates downstream mediators, such as protein kinase C, calcineurin and calcium calmodulin-dependent protein kinase II, which in turn activate transcription factors, such as nuclear factor κB, nuclear factor of activated T cells and cAMP response element binding protein [De, 2011; Rao and Kühl, 2010]....
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...The calcium-dependent pathway is important in embryonic development, cell migration and cancer progression [De, 2011; Kühl, 2004]....
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