Wnt signalling in stem cells and cancer
Citations
5,042 citations
Cites background from "Wnt signalling in stem cells and ca..."
...(Right) Wnt signaling in hair follicles activates bulge stem cells, promotes entry into the hair lineage, and recruits the cells to the transit-amplifying matrix compartment. within the same structure, such as the hair follicle or the intestinal crypt (Reya and Clevers, 2005)....
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...Loss-of-function mutations in Axin have also been found in hepatocellular carcinomas, whereas oncogenic β-catenin mutations occur in a wide variety of solid tumors (reviewed in Reya and Clevers, 2005)....
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...A popular view equates Wnt signaling with maintenance or activation of stem cells (Reya and Clevers, 2005)....
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...Inhibition of Wnt signaling by the transgenic expression of Dkk-1 in adult mice induces the complete loss of crypts, identifying Wnt as the dominant mitogen for crypt progenitor cells throughout life (reviewed in Reya and Clevers, 2005)....
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...Committed progenitors arrest their cell cycle and differentiate when they reach the crypt-villus junction (reviewed in Reya and Clevers, 2005)....
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4,918 citations
4,561 citations
Cites background from "Wnt signalling in stem cells and ca..."
...Loss-of-function mutations in Axin have also been found in hepatocellular carcinomas, whereas oncogenic b-catenin mutations, first described in colon cancer and melanoma (Rubinfeld et al., 1997), occur in a wide variety of solid tumors (reviewed in Reya and Clevers, 2005)....
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3,289 citations
1,698 citations
References
8,999 citations
"Wnt signalling in stem cells and ca..." refers background in this paper
...There is growing evidence that signals such as Notch, Hedgehog and Wnt—pathways that control many developmental processes and are dysregulated in cancer—might regulate self-renewal of haematopoietic progenitors and stem cell...
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4,959 citations
"Wnt signalling in stem cells and ca..." refers background in this paper
...Loss of APC also occurs in most sporadic colorectal cancer...
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4,686 citations
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